Levothyroxine Administration Quiz
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Questions and Answers

What is the general range for synthetic levothyroxine dosage for the treatment of hypothyroidism?

  • 100 to 200 mcg per day
  • 25 to 75 mcg per day
  • 75 to 150 mcg per day (correct)
  • 50 to 100 mcg per day

    • At what dose is thyroid hormone replacement often achieved in older adult patients?

  • 100 mcg per day
  • 50 mcg per day (correct)
  • 25 mcg per day
  • 75 mcg per day

    • What are some patients on thyroid hormone replacement likely to complain of despite normal TSH levels?

  • Increased energy levels
  • Weight loss
  • Reduced appetite
  • Continued clinical manifestations (correct)

    • Why can angina or arrhythmias occur when thyroid replacement is initiated?

    <p>Thyroid hormones enhance the cardiovascular effects of catecholamines</p> Signup and view all the answers

    What occurs when thyroid hormone is given in relation to oxygen demand and delivery?

    <p>Oxygen demand increases, but oxygen delivery cannot be increased unless atherosclerosis improves</p> Signup and view all the answers

    What is the signal that the oxygen needs of the myocardium exceed its blood supply?

    <p>The occurrence of angina and acute coronary syndrome</p> Signup and view all the answers

    What is the effect of metabolism being subnormal on the tolerance of reduced blood supply in hypothyroidism?

    <p>Reduced blood supply is tolerated without overt symptoms of coronary artery disease</p> Signup and view all the answers

    What is the effect of thyroid hormone on oxygen demand and oxygen delivery?

    <p>Oxygen demand increases, but delivery cannot be increased unless atherosclerosis improves</p> Signup and view all the answers

    What is the impact of hypothyroidism on associated serum cholesterol, atherosclerosis, and coronary artery disease?

    <p>Hypothyroidism is associated with elevated serum cholesterol, atherosclerosis, and coronary artery disease</p> Signup and view all the answers

    What is the effect of thyroid hormone on the cardiovascular effects of catecholamines?

    <p>Thyroid hormones enhance the cardiovascular effects of catecholamines</p> Signup and view all the answers

    Which of the following is a contraindication to levothyroxine therapy?

    <p>Hypersensitivity</p> Signup and view all the answers

    What should patients with Addison's disease do before levothyroxine administration?

    <p>Require corticosteroids</p> Signup and view all the answers

    What factors influence the dosage of levothyroxine?

    <p>Severity of hyperthyroidism</p> Signup and view all the answers

    What is a key assessment for the therapeutic effects of levothyroxine therapy?

    <p>Energy levels</p> Signup and view all the answers

    What adverse effect is associated with levothyroxine therapy?

    <p>Tachycardia</p> Signup and view all the answers

    What is emphasized in patient teaching guidelines for levothyroxine therapy?

    <p>Lifelong nature of therapy</p> Signup and view all the answers

    When should patients take levothyroxine?

    <p>In the morning on an empty stomach</p> Signup and view all the answers

    What should patients avoid before taking over-the-counter drugs with levothyroxine?

    <p>Consulting healthcare providers</p> Signup and view all the answers

    What are elderly patients or those with pre-existing heart disease at higher risk of when using levothyroxine?

    <p>Cardiovascular problems</p> Signup and view all the answers

    What is a lifelong requirement for thyroid replacement therapy for hypothyroidism?

    <p>Frequent medical supervision</p> Signup and view all the answers

    What is the range of levothyroxine absorption after oral administration?

    <p>48% to 79%</p> Signup and view all the answers

    What is the half-life of levothyroxine in a euthyroid state?

    <p>6 to 7 days</p> Signup and view all the answers

    What effect does levothyroxine have on metabolic rate, oxygen consumption, and heart rate?

    <p>Increases them</p> Signup and view all the answers

    What is the FDA's stance on using thyroid hormones for obesity or weight loss?

    <p>Issued a BLACK BOX WARNING against it</p> Signup and view all the answers

    When should thyroid hormone administration be discontinued?

    <p>Immediately if angina or arrhythmias occur</p> Signup and view all the answers

    What caution is needed regarding supplements or foods while taking levothyroxine?

    <p>Caution is needed with supplements or foods containing calcium, iron, magnesium, or zinc</p> Signup and view all the answers

    What is necessary for the management of severe hypothyroidism and myxedema coma?

    <p>Prompt, aggressive management</p> Signup and view all the answers

    What interaction do oral thyroid hormones have with warfarin?

    <p>Interact with warfarin</p> Signup and view all the answers

    In which population is cautious treatment necessary, especially those with cardiovascular disease?

    <p>Older adults</p> Signup and view all the answers

    What are the adverse effects of levothyroxine?

    <p>Signs and symptoms of hyperthyroidism, tachycardia, and cardiac dysrhythmias</p> Signup and view all the answers

    Study Notes

    Levothyroxine: Key Points for Safe Use

    • Discontinue thyroid hormone administration immediately if angina or arrhythmias occur
    • Oral thyroid hormones interact with warfarin, adrenergic agents, insulin, oral hypoglycemic medications, and estrogen
    • Caution is needed with supplements or foods containing calcium, iron, magnesium, or zinc
    • Small IV doses of sedative agents may induce profound somnolence and respiratory depression
    • Severe hypothyroidism and myxedema coma require prompt, aggressive management
    • Levothyroxine is the standard of care for long-term treatment of hypothyroidism
    • Levothyroxine absorption varies from 48% to 79% after oral administration
    • The drug has a long half-life of 6 to 7 days in a euthyroid state
    • Levothyroxine increases the metabolic rate, oxygen consumption, and heart rate
    • FDA issued a BLACK BOX WARNING against using thyroid hormones for obesity or weight loss
    • Cautious treatment is necessary in older adults, especially those with cardiovascular disease
    • Adverse effects of levothyroxine include signs and symptoms of hyperthyroidism, tachycardia, and cardiac dysrhythmias

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    Description

    Test your knowledge of safe use and key points for the administration of levothyroxine with this informative quiz. Covering important interactions, cautionary measures, and essential safety guidelines, this quiz will help reinforce your understanding of levothyroxine administration.

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