Podcast
Questions and Answers
What is the general range for synthetic levothyroxine dosage for the treatment of hypothyroidism?
What is the general range for synthetic levothyroxine dosage for the treatment of hypothyroidism?
- 100 to 200 mcg per day
- 25 to 75 mcg per day
- 75 to 150 mcg per day (correct)
- 50 to 100 mcg per day
At what dose is thyroid hormone replacement often achieved in older adult patients?
At what dose is thyroid hormone replacement often achieved in older adult patients?
- 100 mcg per day
- 50 mcg per day (correct)
- 25 mcg per day
- 75 mcg per day
What are some patients on thyroid hormone replacement likely to complain of despite normal TSH levels?
What are some patients on thyroid hormone replacement likely to complain of despite normal TSH levels?
- Increased energy levels
- Weight loss
- Reduced appetite
- Continued clinical manifestations (correct)
Why can angina or arrhythmias occur when thyroid replacement is initiated?
Why can angina or arrhythmias occur when thyroid replacement is initiated?
What occurs when thyroid hormone is given in relation to oxygen demand and delivery?
What occurs when thyroid hormone is given in relation to oxygen demand and delivery?
What is the signal that the oxygen needs of the myocardium exceed its blood supply?
What is the signal that the oxygen needs of the myocardium exceed its blood supply?
What is the effect of metabolism being subnormal on the tolerance of reduced blood supply in hypothyroidism?
What is the effect of metabolism being subnormal on the tolerance of reduced blood supply in hypothyroidism?
What is the effect of thyroid hormone on oxygen demand and oxygen delivery?
What is the effect of thyroid hormone on oxygen demand and oxygen delivery?
What is the impact of hypothyroidism on associated serum cholesterol, atherosclerosis, and coronary artery disease?
What is the impact of hypothyroidism on associated serum cholesterol, atherosclerosis, and coronary artery disease?
What is the effect of thyroid hormone on the cardiovascular effects of catecholamines?
What is the effect of thyroid hormone on the cardiovascular effects of catecholamines?
Which of the following is a contraindication to levothyroxine therapy?
Which of the following is a contraindication to levothyroxine therapy?
What should patients with Addison's disease do before levothyroxine administration?
What should patients with Addison's disease do before levothyroxine administration?
What factors influence the dosage of levothyroxine?
What factors influence the dosage of levothyroxine?
What is a key assessment for the therapeutic effects of levothyroxine therapy?
What is a key assessment for the therapeutic effects of levothyroxine therapy?
What adverse effect is associated with levothyroxine therapy?
What adverse effect is associated with levothyroxine therapy?
What is emphasized in patient teaching guidelines for levothyroxine therapy?
What is emphasized in patient teaching guidelines for levothyroxine therapy?
When should patients take levothyroxine?
When should patients take levothyroxine?
What should patients avoid before taking over-the-counter drugs with levothyroxine?
What should patients avoid before taking over-the-counter drugs with levothyroxine?
What are elderly patients or those with pre-existing heart disease at higher risk of when using levothyroxine?
What are elderly patients or those with pre-existing heart disease at higher risk of when using levothyroxine?
What is a lifelong requirement for thyroid replacement therapy for hypothyroidism?
What is a lifelong requirement for thyroid replacement therapy for hypothyroidism?
What is the range of levothyroxine absorption after oral administration?
What is the range of levothyroxine absorption after oral administration?
What is the half-life of levothyroxine in a euthyroid state?
What is the half-life of levothyroxine in a euthyroid state?
What effect does levothyroxine have on metabolic rate, oxygen consumption, and heart rate?
What effect does levothyroxine have on metabolic rate, oxygen consumption, and heart rate?
What is the FDA's stance on using thyroid hormones for obesity or weight loss?
What is the FDA's stance on using thyroid hormones for obesity or weight loss?
When should thyroid hormone administration be discontinued?
When should thyroid hormone administration be discontinued?
What caution is needed regarding supplements or foods while taking levothyroxine?
What caution is needed regarding supplements or foods while taking levothyroxine?
What is necessary for the management of severe hypothyroidism and myxedema coma?
What is necessary for the management of severe hypothyroidism and myxedema coma?
What interaction do oral thyroid hormones have with warfarin?
What interaction do oral thyroid hormones have with warfarin?
In which population is cautious treatment necessary, especially those with cardiovascular disease?
In which population is cautious treatment necessary, especially those with cardiovascular disease?
What are the adverse effects of levothyroxine?
What are the adverse effects of levothyroxine?
Study Notes
Levothyroxine: Key Points for Safe Use
- Discontinue thyroid hormone administration immediately if angina or arrhythmias occur
- Oral thyroid hormones interact with warfarin, adrenergic agents, insulin, oral hypoglycemic medications, and estrogen
- Caution is needed with supplements or foods containing calcium, iron, magnesium, or zinc
- Small IV doses of sedative agents may induce profound somnolence and respiratory depression
- Severe hypothyroidism and myxedema coma require prompt, aggressive management
- Levothyroxine is the standard of care for long-term treatment of hypothyroidism
- Levothyroxine absorption varies from 48% to 79% after oral administration
- The drug has a long half-life of 6 to 7 days in a euthyroid state
- Levothyroxine increases the metabolic rate, oxygen consumption, and heart rate
- FDA issued a BLACK BOX WARNING against using thyroid hormones for obesity or weight loss
- Cautious treatment is necessary in older adults, especially those with cardiovascular disease
- Adverse effects of levothyroxine include signs and symptoms of hyperthyroidism, tachycardia, and cardiac dysrhythmias
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Description
Test your knowledge of safe use and key points for the administration of levothyroxine with this informative quiz. Covering important interactions, cautionary measures, and essential safety guidelines, this quiz will help reinforce your understanding of levothyroxine administration.
