Leukemia Classification and Cell Types

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Which type of leukemia is derived from stem cells that would normally give rise to the leukocytes containing specific granules like neutrophils and eosinophils?

Myeloid leukemia (correct)

Lymphocytic leukemia

Monocytic leukemia

Erythroid leukemia

How are acute leukemias characterized?

Presence of mature cells

Slow onset and less aggressive behavior

Rapid onset, clinically aggressive, presence of blasts (correct)

Compatible with long survival

Leukemia developing from precursor cells that give rise to monocytes is called:

Erythroid leukemia

Lymphocytic leukemia

Monocytic leukemia (correct)

Myeloid leukemia

What are the characteristics of chronic leukemias?

Compatible with relatively long survival Signup and view all the answers

What is the age range where the disease discussed generally occurs in children?

2-5 years Signup and view all the answers

Which genetic disease is mentioned as having an increased incidence of the discussed illness?

Down syndrome Signup and view all the answers

What are the three cell lineages affected due to the presence of small- to medium-size lymphoblasts?

Anemia, neutropenia, thrombocytopenia Signup and view all the answers

What is a variant of the disease where abnormal cells crowd the marrow but white blood cell count in the blood remains normal or decreased?

Leukemic leukemia Signup and view all the answers

What protein is often produced by neoplastic plasma cells in multiple myeloma?

M-protein Signup and view all the answers

What is termed a precursor lesion that indicates a risk of developing multiple myeloma?

Monoclonal gammopathy of unknown significance (MGUS) Signup and view all the answers

Which type of leukemia is characterized by the presence of a Philadelphia chromosome?

Chronic granulocytic leukemia Signup and view all the answers

What type of precursor cells are abundant in myeloproliferative disorders like chronic myelogenous leukemia?

Myeloid precursors Signup and view all the answers

Which leukemia type may arise as a side effect of radiation or cytotoxic therapy?

Acute myeloid leukemia Signup and view all the answers

What is the most common malignancy of childhood?

Precursor B cell acute lymphoblastic leukemia Signup and view all the answers

What mutation is almost always present in cases of Chronic myelogenous leukemia?

Philadelphia chromosome translocation Signup and view all the answers

Which form of leukemia is equivalent to small cell lymphocytic lymphoma?

Chronic lymphocytic leukemia Signup and view all the answers

What is the primary location for mature B cell leukemia in CLL/SLL?

Bone marrow Signup and view all the answers

What is responsible for the leukemic process in Chronic myelogenous leukemia?

BCR-ABL fusion protein (kinase) Signup and view all the answers

Which type of cells do NOT characterize Chronic lymphocytic leukemia?

+12 chromosomal trisomy cells Signup and view all the answers

What is the treatment strategy for AML after chemotherapy relapse?

Bone marrow transplantation Signup and view all the answers

What is the main difference between CLL and SLL?

Location of the tumor growth Signup and view all the answers

What is a key characteristic shared by AML cells?

+8 chromosomal trisomy Signup and view all the answers