22 Questions
Which type of leukemia is derived from stem cells that would normally give rise to the leukocytes containing specific granules like neutrophils and eosinophils?
Myeloid leukemia
How are acute leukemias characterized?
Rapid onset, clinically aggressive, presence of blasts
Leukemia developing from precursor cells that give rise to monocytes is called:
Monocytic leukemia
What are the characteristics of chronic leukemias?
Compatible with relatively long survival
What is the age range where the disease discussed generally occurs in children?
2-5 years
Which genetic disease is mentioned as having an increased incidence of the discussed illness?
Down syndrome
What are the three cell lineages affected due to the presence of small- to medium-size lymphoblasts?
Anemia, neutropenia, thrombocytopenia
What is a variant of the disease where abnormal cells crowd the marrow but white blood cell count in the blood remains normal or decreased?
Leukemic leukemia
What protein is often produced by neoplastic plasma cells in multiple myeloma?
M-protein
What is termed a precursor lesion that indicates a risk of developing multiple myeloma?
Monoclonal gammopathy of unknown significance (MGUS)
Which type of leukemia is characterized by the presence of a Philadelphia chromosome?
Chronic granulocytic leukemia
What type of precursor cells are abundant in myeloproliferative disorders like chronic myelogenous leukemia?
Myeloid precursors
Which leukemia type may arise as a side effect of radiation or cytotoxic therapy?
Acute myeloid leukemia
What is the most common malignancy of childhood?
Precursor B cell acute lymphoblastic leukemia
What mutation is almost always present in cases of Chronic myelogenous leukemia?
Philadelphia chromosome translocation
Which form of leukemia is equivalent to small cell lymphocytic lymphoma?
Chronic lymphocytic leukemia
What is the primary location for mature B cell leukemia in CLL/SLL?
Bone marrow
What is responsible for the leukemic process in Chronic myelogenous leukemia?
BCR-ABL fusion protein (kinase)
Which type of cells do NOT characterize Chronic lymphocytic leukemia?
+12 chromosomal trisomy cells
What is the treatment strategy for AML after chemotherapy relapse?
Bone marrow transplantation
What is the main difference between CLL and SLL?
Location of the tumor growth
What is a key characteristic shared by AML cells?
+8 chromosomal trisomy
Learn about the classification of leukemia based on cell type and maturity of proliferating cells. Understand the difference between myeloid and lymphoid leukemia as well as myeloid versus monocytic leukemia.
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