Podcast
Questions and Answers
What is the main mechanism by which classic chemotherapy agents function?
What is the main mechanism by which classic chemotherapy agents function?
- Affecting DNA machinery or being nucleotide analogs or affecting cytoskeleton (correct)
- Stimulating the immune system
- Inducing apoptosis in cancer cells
- Inhibiting cell migration
Why do children experience more severe side effects from chemotherapy?
Why do children experience more severe side effects from chemotherapy?
- Because their immune system is more compromised
- Because their cells are more sensitive to chemotherapy
- Because their cytoskeleton is more fragile
- Because they have more dividing cells (correct)
What is the primary cause of Medulloblastoma?
What is the primary cause of Medulloblastoma?
- Mutations in the TP53 gene
- Abnormal regulation of GCP proliferation (correct)
- Overexpression of the MYC gene
- Deletions in the CDKN2A gene
What percentage of Medulloblastomas are caused by mutations in the SHH pathway?
What percentage of Medulloblastomas are caused by mutations in the SHH pathway?
What is the most common symptom of Medulloblastoma?
What is the most common symptom of Medulloblastoma?
At what age are most Medulloblastomas diagnosed?
At what age are most Medulloblastomas diagnosed?
What is the primary diagnostic tool used for Medulloblastoma?
What is the primary diagnostic tool used for Medulloblastoma?
What is the role of the cytoskeleton in cell division?
What is the role of the cytoskeleton in cell division?
Which of the following is NOT a function of chemotherapy agents?
Which of the following is NOT a function of chemotherapy agents?
What percentage of brain tumors are Medulloblastomas?
What percentage of brain tumors are Medulloblastomas?
What is the name of the gene that is often mutated in Basal cell carcinoma and Medulloblastoma?
What is the name of the gene that is often mutated in Basal cell carcinoma and Medulloblastoma?
What is the prognosis of children with medulloblastoma 5 years after diagnosis?
What is the prognosis of children with medulloblastoma 5 years after diagnosis?
What is the result of a heterozygous knockout of the Ptc gene in mice?
What is the result of a heterozygous knockout of the Ptc gene in mice?
Why do only 50% of mice with a heterozygous Ptc knockout develop medulloblastoma?
Why do only 50% of mice with a heterozygous Ptc knockout develop medulloblastoma?
What technique is used to study a few cells at a time in the Ptc-/+ mouse model?
What technique is used to study a few cells at a time in the Ptc-/+ mouse model?
What is the result of loss of heterozygosity of the Ptc gene in granule cell precursors?
What is the result of loss of heterozygosity of the Ptc gene in granule cell precursors?
What is the role of the Shh pathway in medulloblastoma?
What is the role of the Shh pathway in medulloblastoma?
What is the effect of suppressing the Shh pathway on medulloblastoma formation?
What is the effect of suppressing the Shh pathway on medulloblastoma formation?
What is the effect of inhibiting the Hedgehog pathway in young mice?
What is the effect of inhibiting the Hedgehog pathway in young mice?
What is the relationship between Gorlin syndrome and basal cell carcinoma?
What is the relationship between Gorlin syndrome and basal cell carcinoma?
What is the effect of GDC-0449 therapy on patients with basal cell carcinoma?
What is the effect of GDC-0449 therapy on patients with basal cell carcinoma?
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