Podcast
Questions and Answers
What is the process by which iris epithelial cells regain their ability to differentiate into lens cells?
What is the process by which iris epithelial cells regain their ability to differentiate into lens cells?
- De-differentiation followed by redifferentiation (correct)
- Differentiation from mesenchymal stem cells
- Transdifferentiation
- Epithelial-mesenchymal transition
What is the primary cause of elevated intraocular pressure in glaucoma?
What is the primary cause of elevated intraocular pressure in glaucoma?
- Inflammation of the optic nerve
- Degeneration of retinal ganglion cells
- Blockage of the trabecular meshwork (correct)
- Overproduction of aqueous humor
What is the characteristic atrophy of the optic nerve in glaucoma?
What is the characteristic atrophy of the optic nerve in glaucoma?
- Axonal degeneration
- Neuroinflammation
- Crushing of the optic nerve (correct)
- Demylination of the optic nerve
What is the primary cell type affected in retinitis pigmentosa?
What is the primary cell type affected in retinitis pigmentosa?
What is the characteristic feature of dry age-related macular degeneration?
What is the characteristic feature of dry age-related macular degeneration?
What is the purpose of Pax6 cells in lens regeneration?
What is the purpose of Pax6 cells in lens regeneration?
What is the advantage of the Microbead Occlusion Model of Ocular Hypertension?
What is the advantage of the Microbead Occlusion Model of Ocular Hypertension?
What is the role of Wnt signaling in lens regeneration?
What is the role of Wnt signaling in lens regeneration?
What is the primary cause of blindness in retinitis pigmentosa?
What is the primary cause of blindness in retinitis pigmentosa?
What is the advantage of using transgenic mice expressing a mutant form of human ELOVL4 in AMD research?
What is the advantage of using transgenic mice expressing a mutant form of human ELOVL4 in AMD research?
What is the primary source of neurogenesis in response to damage of the anterior retina in amphibians, fish, and birds?
What is the primary source of neurogenesis in response to damage of the anterior retina in amphibians, fish, and birds?
What is the primary source of retinal progenitors or stem cells in amphibians?
What is the primary source of retinal progenitors or stem cells in amphibians?
What is the primary source of retinal regeneration in fish?
What is the primary source of retinal regeneration in fish?
What is required for satisfactory results in stem cell transplantations in the retina?
What is required for satisfactory results in stem cell transplantations in the retina?
What was the outcome of the key experiment in mice, where retinal cells were made from iPSCs or ESCs and transplanted under the retina?
What was the outcome of the key experiment in mice, where retinal cells were made from iPSCs or ESCs and transplanted under the retina?
What allows Müller glial cells to regenerate damaged neurons in fish?
What allows Müller glial cells to regenerate damaged neurons in fish?
What is the result of expressing/activating Ascl1 in Müller glial cells in mice?
What is the result of expressing/activating Ascl1 in Müller glial cells in mice?
What is the result of co-expressing Ikzf1 and Ikzf4 in Müller glia?
What is the result of co-expressing Ikzf1 and Ikzf4 in Müller glia?
Are Ikzf1 and Ikzf4 general reprogramming factors?
Are Ikzf1 and Ikzf4 general reprogramming factors?
What is the result of Ikzf1/4 reprogramming in mouse embryonic fibroblasts?
What is the result of Ikzf1/4 reprogramming in mouse embryonic fibroblasts?
What type of collagen is predominantly found in the stroma of the cornea?
What type of collagen is predominantly found in the stroma of the cornea?
Which layer of the cornea has low (if any) regenerative potential?
Which layer of the cornea has low (if any) regenerative potential?
What is the main cause of blindness resulting from cataracts?
What is the main cause of blindness resulting from cataracts?
Which condition leads to obstruction of light passage due to clouding in the lens?
Which condition leads to obstruction of light passage due to clouding in the lens?
What is the main treatment for cataracts?
What is the main treatment for cataracts?
Which cell replacement therapy is mentioned as a regenerative approach for cornea repair?
Which cell replacement therapy is mentioned as a regenerative approach for cornea repair?
Which layer of the cornea is known for its exposure to air and high regenerative potential?
Which layer of the cornea is known for its exposure to air and high regenerative potential?
What is the risk factor for cataracts that is mentioned as being responsible for 48% of world blindness?
What is the risk factor for cataracts that is mentioned as being responsible for 48% of world blindness?
What is the membrane structure that serves as the basement membrane in the cornea?
What is the membrane structure that serves as the basement membrane in the cornea?
Which part of the cornea is exposed to aqueous humor and characterized as simple squamous epithelium?
Which part of the cornea is exposed to aqueous humor and characterized as simple squamous epithelium?
