Podcast
Questions and Answers
What is the primary mechanism by which Cytochrome P-450 (Cyp) enzymes contribute to DNA damage?
What is the primary mechanism by which Cytochrome P-450 (Cyp) enzymes contribute to DNA damage?
- Direct interaction with DNA to cause mutations
- Detoxification of carcinogens through oxidation
- Conversion of chemically inert pro-carcinogens into ultimate carcinogens (correct)
- Activation of DNA repair mechanisms
What is the primary consequence of DNA damage caused by UV radiation?
What is the primary consequence of DNA damage caused by UV radiation?
- Point mutations due to base deamination
- Covalent cross-links between adjacent pyrimidine bases (correct)
- ROS-mediated oxidation of bases
- Formation of DNA adducts
What is the primary function of p53 in response to DNA damage?
What is the primary function of p53 in response to DNA damage?
- Cell cycle arrest (correct)
- DNA replication
- Transcriptional activation of DNA repair genes
- Cellular apoptosis
What is the characteristic of p53 mutations detected in most common cancers?
What is the characteristic of p53 mutations detected in most common cancers?
What is the consequence of loss of the remaining wild-type allele in p53 mutations?
What is the consequence of loss of the remaining wild-type allele in p53 mutations?
What is the primary function of DNA glycosylase enzymes in DNA repair?
What is the primary function of DNA glycosylase enzymes in DNA repair?
What is the primary function of Base Excision Repair (BER)?
What is the primary function of Base Excision Repair (BER)?
Which DNA repair mechanism is responsible for repairing damage caused by UV light and X-rays?
Which DNA repair mechanism is responsible for repairing damage caused by UV light and X-rays?
What is the role of DNA glycosylase enzymes in Base Excision Repair (BER)?
What is the role of DNA glycosylase enzymes in Base Excision Repair (BER)?
What is the consequence of inherited defects in DNA repair genes?
What is the consequence of inherited defects in DNA repair genes?
What is the purpose of checkpoint proteins in DNA repair?
What is the purpose of checkpoint proteins in DNA repair?
How do chemotherapy agents target cancer cells?
How do chemotherapy agents target cancer cells?
What is the estimated number of errors/mutations that occur per person per day due to DNA damage or during division?
What is the estimated number of errors/mutations that occur per person per day due to DNA damage or during division?
Which type of DNA repair mechanism is responsible for correcting damage caused by ultraviolet light?
Which type of DNA repair mechanism is responsible for correcting damage caused by ultraviolet light?
What is the role of APOBECs in the context of DNA damage and repair?
What is the role of APOBECs in the context of DNA damage and repair?
What is the consequence of 8-oxo-dG mis-base pairing with deoxyadenosine during DNA replication?
What is the consequence of 8-oxo-dG mis-base pairing with deoxyadenosine during DNA replication?
What is the primary function of checkpoint proteins in the context of DNA damage and repair?
What is the primary function of checkpoint proteins in the context of DNA damage and repair?
What is the relevance of DNA repair mechanisms in the development and treatment of cancer?
What is the relevance of DNA repair mechanisms in the development and treatment of cancer?
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