Lecture 3: B cells

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What is the main task of antibodies?

Activate inflammation

Promote pathogen replication

Destroy healthy cells

Prevent pathogens from entering tissues (correct)

What is the function of Fab fragments in antibodies?

Neutralize antigens

Contain antigen-binding domains (correct)

Bind to Fc receptors

Enhance flexibility

What is the role of the Fc fragment in antibodies?

Bind to antigens

Recognized by Fc receptors on immune cells (correct)

Neutralize pathogens

Contain antigen-binding domains

Which region in antibodies confers antigen specificity by making direct contact with antigens?

Variable region Signup and view all the answers

How many Fab fragments are present per antibody?

Two Signup and view all the answers

Which chains make up the structure of an Immunoglobulin (antibody)?

2 heavy chains and 2 light chains Signup and view all the answers

What is the significance of the Complementarity determining regions (CDR) in antibodies?

Confer antigen specificity by contacting antigens Signup and view all the answers

How many types of Immunoglobulin domains are there?

Four Signup and view all the answers

'Opsonization' refers to the process of:

'Enhancing phagocytosis' Signup and view all the answers

What gives antibodies the ability to bind to different epitopes and structurally different antigens with varying affinities?

Flexibility in the antibody structure Signup and view all the answers

Which class of antibody is born out of immature B cells and then develops into one of four classes through switching?

IgM Signup and view all the answers

What is the most abundant class of antibody found in plasma?

IgG Signup and view all the answers

Which class of antibody is involved in allergic reactions and produced in response to Helminth infections?

IgE Signup and view all the answers

Which class of antibody is expressed as a monomer in plasma but as a dimer in mucous secretions through the J chain?

IgA Signup and view all the answers

What initiates the complement cascade most effectively among the antibody classes?

IgM Signup and view all the answers

Which antibody class is known for being important for mucosal immunity and has two subclasses, IgA1 and IgA2?

IgA Signup and view all the answers

Which class of antibodies contains a variable region and four constant regions, making it involved in allergic reactions?

IgE Signup and view all the answers

Which antibody class is part of the first wave of secreted antibodies and plays a role in TH2 response?

IgD Signup and view all the answers