Lecture 3: B cells
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Questions and Answers

What is the main task of antibodies?

  • Activate inflammation
  • Promote pathogen replication
  • Destroy healthy cells
  • Prevent pathogens from entering tissues (correct)

What is the function of Fab fragments in antibodies?

  • Neutralize antigens
  • Contain antigen-binding domains (correct)
  • Bind to Fc receptors
  • Enhance flexibility

What is the role of the Fc fragment in antibodies?

  • Bind to antigens
  • Recognized by Fc receptors on immune cells (correct)
  • Neutralize pathogens
  • Contain antigen-binding domains

Which region in antibodies confers antigen specificity by making direct contact with antigens?

<p>Variable region (C)</p> Signup and view all the answers

How many Fab fragments are present per antibody?

<p>Two (D)</p> Signup and view all the answers

Which chains make up the structure of an Immunoglobulin (antibody)?

<p>2 heavy chains and 2 light chains (B)</p> Signup and view all the answers

What is the significance of the Complementarity determining regions (CDR) in antibodies?

<p>Confer antigen specificity by contacting antigens (D)</p> Signup and view all the answers

How many types of Immunoglobulin domains are there?

<p>Four (B)</p> Signup and view all the answers

'Opsonization' refers to the process of:

<p>'Enhancing phagocytosis' (B)</p> Signup and view all the answers

What gives antibodies the ability to bind to different epitopes and structurally different antigens with varying affinities?

<p>Flexibility in the antibody structure (C)</p> Signup and view all the answers

Which class of antibody is born out of immature B cells and then develops into one of four classes through switching?

<p>IgM (A)</p> Signup and view all the answers

What is the most abundant class of antibody found in plasma?

<p>IgG (A)</p> Signup and view all the answers

Which class of antibody is involved in allergic reactions and produced in response to Helminth infections?

<p>IgE (B)</p> Signup and view all the answers

Which class of antibody is expressed as a monomer in plasma but as a dimer in mucous secretions through the J chain?

<p>IgA (C)</p> Signup and view all the answers

What initiates the complement cascade most effectively among the antibody classes?

<p>IgM (D)</p> Signup and view all the answers

Which antibody class is known for being important for mucosal immunity and has two subclasses, IgA1 and IgA2?

<p>IgA (C)</p> Signup and view all the answers

Which class of antibodies contains a variable region and four constant regions, making it involved in allergic reactions?

<p>IgE (D)</p> Signup and view all the answers

Which antibody class is part of the first wave of secreted antibodies and plays a role in TH2 response?

<p>IgD (A)</p> Signup and view all the answers

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