Lecture 3: B cells
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Questions and Answers

What is the main task of antibodies?

  • Activate inflammation
  • Promote pathogen replication
  • Destroy healthy cells
  • Prevent pathogens from entering tissues (correct)
  • What is the function of Fab fragments in antibodies?

  • Neutralize antigens
  • Contain antigen-binding domains (correct)
  • Bind to Fc receptors
  • Enhance flexibility
  • What is the role of the Fc fragment in antibodies?

  • Bind to antigens
  • Recognized by Fc receptors on immune cells (correct)
  • Neutralize pathogens
  • Contain antigen-binding domains
  • Which region in antibodies confers antigen specificity by making direct contact with antigens?

    <p>Variable region</p> Signup and view all the answers

    How many Fab fragments are present per antibody?

    <p>Two</p> Signup and view all the answers

    Which chains make up the structure of an Immunoglobulin (antibody)?

    <p>2 heavy chains and 2 light chains</p> Signup and view all the answers

    What is the significance of the Complementarity determining regions (CDR) in antibodies?

    <p>Confer antigen specificity by contacting antigens</p> Signup and view all the answers

    How many types of Immunoglobulin domains are there?

    <p>Four</p> Signup and view all the answers

    'Opsonization' refers to the process of:

    <p>'Enhancing phagocytosis'</p> Signup and view all the answers

    What gives antibodies the ability to bind to different epitopes and structurally different antigens with varying affinities?

    <p>Flexibility in the antibody structure</p> Signup and view all the answers

    Which class of antibody is born out of immature B cells and then develops into one of four classes through switching?

    <p>IgM</p> Signup and view all the answers

    What is the most abundant class of antibody found in plasma?

    <p>IgG</p> Signup and view all the answers

    Which class of antibody is involved in allergic reactions and produced in response to Helminth infections?

    <p>IgE</p> Signup and view all the answers

    Which class of antibody is expressed as a monomer in plasma but as a dimer in mucous secretions through the J chain?

    <p>IgA</p> Signup and view all the answers

    What initiates the complement cascade most effectively among the antibody classes?

    <p>IgM</p> Signup and view all the answers

    Which antibody class is known for being important for mucosal immunity and has two subclasses, IgA1 and IgA2?

    <p>IgA</p> Signup and view all the answers

    Which class of antibodies contains a variable region and four constant regions, making it involved in allergic reactions?

    <p>IgE</p> Signup and view all the answers

    Which antibody class is part of the first wave of secreted antibodies and plays a role in TH2 response?

    <p>IgD</p> Signup and view all the answers

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