Lecture 26: Vestibular System
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Questions and Answers

What effect does the deflection of stereocilia towards the kinocilium have on the hair cell physiology?

  • It prevents the release of neurotransmitters.
  • It causes hyperpolarization of the cell.
  • It opens voltage-gated calcium channels, resulting in depolarization. (correct)
  • It leads to an increase in potassium ion efflux.
  • Which ion is more abundant in endolymph compared to perilymph?

  • Sodium ions (Na+)
  • Calcium ions (Ca2+)
  • Potassium ions (K+) (correct)
  • Chloride ions (Cl-)
  • What occurs when hair cells experience hyperpolarization?

  • Calcium channels remain open.
  • Potassium channels close.
  • The rate of neurotransmitter release decreases. (correct)
  • The firing rate of the afferent fibers increases.
  • How many semicircular canals are located on each side of the head?

    <p>Three (B)</p> Signup and view all the answers

    What happens when the stimulation of hair cells ceases?

    <p>Stereocilia return to their resting position. (C)</p> Signup and view all the answers

    What is the primary function of the vestibular system?

    <p>Sensing motion and maintaining postural stability (A)</p> Signup and view all the answers

    Which structures are part of the vestibular system?

    <p>Otolith organs and semicircular canals (B)</p> Signup and view all the answers

    What causes depolarization in vestibular hair cells?

    <p>Stereocilia moving towards the kinocilium (A)</p> Signup and view all the answers

    How does hyperpolarization affect vestibular hair cells?

    <p>It decreases the firing rate of afferent neurons (C)</p> Signup and view all the answers

    What role do the otolith organs play in the vestibular system?

    <p>They sense linear acceleration and gravity (B)</p> Signup and view all the answers

    What happens to the hair cells during motion in one direction?

    <p>Short hairs tip towards tall hairs, stimulating nerve activity (D)</p> Signup and view all the answers

    What causes the spontaneous activity of afferent neurons in the vestibular system at rest?

    <p>Open calcium (Ca2+) channels (D)</p> Signup and view all the answers

    What condition is commonly associated with dysfunctions of the vestibular system?

    <p>Motion sickness (D)</p> Signup and view all the answers

    What is the primary role of the semicircular canals?

    <p>Detecting angular head acceleration (A)</p> Signup and view all the answers

    Which fluid is contained within the membranous canal of the semicircular canals?

    <p>Endolymph (A)</p> Signup and view all the answers

    What is the function of the crista ampullaris within the ampulla of the semicircular canals?

    <p>Housing hair cells that detect fluid motion (C)</p> Signup and view all the answers

    How do coplanar canals function during angular movement?

    <p>They create a push-pull mechanism in response to motion (C)</p> Signup and view all the answers

    Which of the following can affect both hearing and balance?

    <p>Fluid imbalance in the membranous labyrinth (A)</p> Signup and view all the answers

    What does hair cell movement towards the kinocilium cause?

    <p>Increased discharge rate of the afferent nerve (C)</p> Signup and view all the answers

    How are the auditory and vestibular systems similar?

    <p>Both use hair cells as motion detectors (C)</p> Signup and view all the answers

    What characterizes the perilymph between the membranous and bony canals?

    <p>Low in potassium, high in sodium (A)</p> Signup and view all the answers

    What is the orientation of the utricle and saccule with respect to gravity?

    <p>The utricle lies horizontally, and the saccule is oriented vertically. (B)</p> Signup and view all the answers

    What do otolith organs primarily provide information about?

    <p>Linear acceleration and head position changes relative to gravity. (C)</p> Signup and view all the answers

    What is the function of the otoliths embedded in the macula?

    <p>To provide shear force to hair cells during linear acceleration. (C)</p> Signup and view all the answers

    How are the hair cells within the utricle and saccule oriented relative to the striola?

    <p>Utricle hair cells are oriented towards the striola, while saccule hair cells are oriented away from it. (B)</p> Signup and view all the answers

    What is a key similarity between otolith organs and semicircular canals?

    <p>Both use hair cells to detect motion. (C)</p> Signup and view all the answers

    What does the motion of otolith crystals toward the kinocilium lead to?

    <p>Excitation of hair cell activity. (D)</p> Signup and view all the answers

    What effect does the structure of the striola have on the otolith organs?

    <p>It divides the macula into regions with different hair cell polarities. (C)</p> Signup and view all the answers

    What is the approximate length of otolith crystals in humans?

    <p>3 - 30 µm. (D)</p> Signup and view all the answers

    Flashcards

    Vestibular System Function

    The vestibular system senses head motion, maintains posture, and stabilizes vision during head movement.

    Vestibular Hair Cells

    Sensory cells in the inner ear that detect head movement by detecting hair bundle deflection.

    Hair Cell Depolarization

    Occurs when stereocilia move towards the kinocilium, increasing neurotransmitter release.

    Hair Cell Hyperpolarization

    Occurs when stereocilia move away from the kinocilium, decreasing neurotransmitter release.

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    Semicircular Canals

    Part of the vestibular system detecting rotational head movement.

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    Otolith Organs

    Part of the vestibular system, detecting linear acceleration and head position relative to gravity.

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    Vestibular Afferents

    Nerves that carry signals from vestibular hair cells to the brainstem.

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    Spontaneous Activity in Afferents

    Constant signal from hair cells, which occur even without head motion.

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    Vestibular Hair Cell Depolarization

    Results from potassium (K+) flowing into the cell, caused by stereocilia deflection towards the kinocilium, opening K+ channels.

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    Vestibular Hair Cell Hyperpolarization

    Caused by potassium (K+) flowing out of the cell, due to stereocilia deflection away from the kinocilium, thus closing K+ channels.

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    Semicircular Canals Orientation

    Located at right angles (orthogonal) to each other.

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    Hair Cell Firing Rate Increase

    Increases when stereocilia bend towards the kinocilium, causing depolarization and neurotransmitter release.

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    Hair Cell Firing Rate Decrease

    Occurs due to stereocilia bending away from the kinocilium, causing hyperpolarization and less neurotransmitter release.

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    Utricle orientation

    The utricle is oriented horizontally within the inner ear.

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    Saccule orientation

    The saccule is oriented vertically within the inner ear.

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    Otolith function

    Otoliths are small calcium carbonate crystals that detect linear acceleration and head position relative to gravity.

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    Otolith structure

    Each otolith organ has a sheet of hair cells (macula) embedded in a gelatinous mass with otoliths.

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    Hair cell orientation in utricle

    Utricle hair cells are oriented towards the striola, a central stripe that divides the macula.

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    Hair cell orientation in saccule

    Saccule hair cells are oriented away from the striola.

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    Striola's function

    The striola determines the direction of hair cell excitation and inhibition, making otolithic organs sensitive to linear motion in multiple directions.

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    Otolith vs. semicircular canals

    Both are inner ear sensory organs using hair cells, but otolith organs detect linear acceleration and head position, while semicircular canals detect rotational movement.

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    What's the main fluid in the semicircular canals?

    Endolymph is a fluid with high potassium (K+) and low sodium (Na+) concentration found within the membranous canals of the vestibular system.

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    What fluid surrounds the membranous canal?

    Perilymph is fluid with low potassium (K+) and high sodium (Na+) concentration found in the space between the membranous canal and bony canal.

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    What happens in the ampulla?

    The ampulla is a bulge in each semicircular canal containing hair cells (crista ampullaris) and a gelatinous structure (cupula) that senses endolymph movement.

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    How does endolymph movement affect hair cells?

    When endolymph moves due to head rotation, the cupula deflects, causing hair cell stereocilia to move towards or away from the kinocilium, altering neurotransmitter release.

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    How are semicircular canals functionally paired?

    Each canal has a counterpart on the opposite side of the head, working as a push-pull system. Rotation in one direction excites one pair, while inhibiting the other.

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    How are auditory and vestibular systems similar?

    They share a common fluid system (membranous labyrinth), rely on hair cell motion detectors, and are both innervated by the 8th cranial nerve.

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    What happens if the membranous labyrinth is damaged?

    Both hearing and balance can be affected due to the shared fluid system, potentially leading to disorders like Meniere's Disease.

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    How do hair cells in auditory and vestibular systems work?

    Both use hair cells as motion detectors, functioning on nearly identical principles to sense either sound waves or head movement.

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    Study Notes

    Lecture 26: Vestibular System

    • The vestibular system is responsible for sensing motion, posture, and image stabilization during head movement.
    • Vestibular receptors are located within the inner ear labyrinth.
    • The system is composed of otolith organs (saccule and utricle) and semicircular canals.

    Topics

    • Vestibular hair cells
    • Semicircular canals
    • Otolith organs

    Overview

    • The vestibular system senses motion, postural stability, and image stabilization during head movement.
    • Receptors in the inner ear labyrinth provide information about head motion and orientation relative to gravity.
    • The system assists in coordinating body position with other sensory information.

    Vestibular Hair Cells

    • Motion is detected by hair cells (kinocilium and stereocilia) in the vestibular organs.
    • Deflection of these hairs causes hyperpolarization or depolarization depending on the direction of deflection.
    • Depolarization is caused by stereocilia movement towards the kinocilium.
    • Hyperpolarization is caused by stereocilia movement away from the kinocilium.
    • Different polarization affects the primary vestibular afferent firing rate to the brainstem.
    • Spontaneous activity at rest is due to open Ca²⁺ channels, causing a constant neurotransmitter release.
    • Motion in one direction stimulates firing, while the opposite direction inhibits firing of the cranial 8th nerve.

    Semicircular Canals

    • Each canal is designed to detect angular acceleration during head rotation.
    • The membranous canal is within a bony canal, filled with endolymph (high K⁺, low Na⁺).
    • The space between the membranous and bony canals is filled with perilymph (low K⁺, high Na⁺).
    • Hair cells inside the ampulla are located within a gelatinous structure called the cupula.
    • Endolymph motion caused by angular head motion results in cupula deflection, which causes stereocilia movement towards or away from the kinocilium.
    • Motion generates differences in transmitter release and discharge rates in the afferent nerves, proportional to the angular velocity.
    • Semicircular canals are functionally paired, with opposite canals acting as push-pull pairs, one exciting and the other inhibiting.

    Otolith Organs (Utricle and Saccule)

    • These organs provide information about linear acceleration and changes in head position relative to gravity.
    • The utricle lies horizontally, and the saccule is oriented vertically.
    • Hair cells (macula) within the utricle and saccule have cilia embedded in a gelatinous mass containing calcium carbonate crystals (otoliths).
    • Otoliths move due to gravity or acceleration, and cause a shear force on the stereocilia.
    • This shear force leads to depolarization (and excitation) or hyperpolarization (inhibition) in the hair cells.
    • The striola is the central stripe dividing the macula into regions of opposing hair cell polarity (towards or away).
    • Otolith organs are sensitive to linear motion due to the striola's curvature.
    • In contrast, semicircular canal hair cells sense motion in the same direction.

    Similarities between the auditory and vestibular systems

    • Both systems use a common fluid system (membranous labyrinth).
    • Both involve hair cell motion detectors with similar principles.
    • Both are innervated by branches of the same cranial nerve (8th).

    Summary

    • Specialized receptors (otolith organs and semicircular canals) within the inner ear detect forces related to head movement and gravity.
    • Motion is detected by vestibular sensory organs through the deflection of hair cells.
    • Motion causes changes in the electrical potential, transmitter release, and firing rates.
    • Hair cells in semicircular canals are oriented in the same direction.
    • Hair cells within otolith organs demonstrate opposing orientations to detect opposing directions of motion and acceleration.
    • Vestibular and auditory systems share a common fluid system, hair cell detectors, and innervation.

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    Description

    Explore the intricacies of the vestibular system in this quiz. Learn how the system senses motion, maintains posture, and stabilizes images during head movement. Delve into the roles of vestibular hair cells, semicircular canals, and otolith organs.

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