23 Questions
What is the main cause of redness and heat during inflammation?
Altered vascular flow
Which process allows plasma proteins and leukocytes to enter sites of infection or tissue damage?
Increased vascular permeability
What type of fluid accumulation results in edema with high protein content and cells?
Exudate
What is the main mechanism behind the prolonged response phase of fluid loss and permeability during inflammation?
Direct endothelial injury
Which step involves migration of leukocytes across the endothelium during inflammation?
Transmigration
What family of proteins mediates the process of leukocyte rolling on the endothelial surface?
Selectin family
Which proteins interact with leukocyte integrins to mediate leukocyte adhesion to endothelial cells?
Igs superfamily
What is the main site of leukocyte accumulation before transmigration across the endothelium?
Lumen
What is the primary function of extravasation during inflammation?
Delivery of leukocytes to the site of injury
Which event triggers the movement of transmigrated leukocytes toward a chemotactic agent?
Chemotactic response
What are the cardinal signs of inflammation according to Celsus?
Heat, redness, edema, pain
Which cells recognize microbes and damaged cells and trigger the vascular and cellular reactions of inflammation?
Macrophages
What are the four major components of acute inflammation?
Vascular changes, cellular events, mediators, microvascular changes
What is the earliest manifestation of acute inflammation in terms of vascular changes?
Vasodilation
Which event leads to the main local manifestation of erythema and warmth in acute inflammation?
Vascular dilation
Who first listed the cardinal signs of inflammation during the first century AD?
Celsus
Which component triggers vasodilation in the event of inflammation?
Histamine
What is the unique feature of the inflammatory process?
Reaction of blood vessels leading to fluid and leukocyte accumulation in extravascular tissues
What does inflammation aim to eliminate?
Both the initial cause of cell injury and the resulting necrotic cells and tissues
What is the primary goal of inflammation?
To initiate the repair process
What does the suffix '-itis' after an organ denote?
Inflammation in that site
How does inflammation respond to vascularized tissues?
It delivers leukocytes and molecules of host defense to those tissues
Why is inflammation described as a protective response?
Because it is intended to eliminate the initial cause of cell injury and necrotic cells
Learn about the importance of the inflammatory response in the survival of organisms as explained by Dr. Amani Mahbub. The text covers the role of inflammation in eliminating foreign invaders and damaged tissues, as well as the unique features of the inflammatory process.
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