Learning Outcomes 2 - Dr. Amani Mahbub Explanation on Inflammation
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Questions and Answers

What is the main cause of redness and heat during inflammation?

  • Altered vascular flow (correct)
  • Increased hydrostatic pressure
  • Increased vascular permeability
  • Accumulation of neutrophils

Which process allows plasma proteins and leukocytes to enter sites of infection or tissue damage?

  • Endothelial injury
  • Stasis of blood flow
  • Vasodilation
  • Increased vascular permeability (correct)

What type of fluid accumulation results in edema with high protein content and cells?

  • Hydrostatic prostatie
  • Histamine-induced fluid
  • Exudate (correct)
  • Transudate

What is the main mechanism behind the prolonged response phase of fluid loss and permeability during inflammation?

<p>Direct endothelial injury (B)</p> Signup and view all the answers

Which step involves migration of leukocytes across the endothelium during inflammation?

<p>Transmigration (C)</p> Signup and view all the answers

What family of proteins mediates the process of leukocyte rolling on the endothelial surface?

<p>Selectin family (A)</p> Signup and view all the answers

Which proteins interact with leukocyte integrins to mediate leukocyte adhesion to endothelial cells?

<p>Igs superfamily (C)</p> Signup and view all the answers

What is the main site of leukocyte accumulation before transmigration across the endothelium?

<p>Lumen (A)</p> Signup and view all the answers

What is the primary function of extravasation during inflammation?

<p>Delivery of leukocytes to the site of injury (A)</p> Signup and view all the answers

Which event triggers the movement of transmigrated leukocytes toward a chemotactic agent?

<p>Chemotactic response (B)</p> Signup and view all the answers

What are the cardinal signs of inflammation according to Celsus?

<p>Heat, redness, edema, pain (C)</p> Signup and view all the answers

Which cells recognize microbes and damaged cells and trigger the vascular and cellular reactions of inflammation?

<p>Macrophages (A)</p> Signup and view all the answers

What are the four major components of acute inflammation?

<p>Vascular changes, cellular events, mediators, microvascular changes (D)</p> Signup and view all the answers

What is the earliest manifestation of acute inflammation in terms of vascular changes?

<p>Vasodilation (A)</p> Signup and view all the answers

Which event leads to the main local manifestation of erythema and warmth in acute inflammation?

<p>Vascular dilation (A)</p> Signup and view all the answers

Who first listed the cardinal signs of inflammation during the first century AD?

<p>Celsus (A)</p> Signup and view all the answers

Which component triggers vasodilation in the event of inflammation?

<p>Histamine (A)</p> Signup and view all the answers

What is the unique feature of the inflammatory process?

<p>Reaction of blood vessels leading to fluid and leukocyte accumulation in extravascular tissues (D)</p> Signup and view all the answers

What does inflammation aim to eliminate?

<p>Both the initial cause of cell injury and the resulting necrotic cells and tissues (A)</p> Signup and view all the answers

What is the primary goal of inflammation?

<p>To initiate the repair process (C)</p> Signup and view all the answers

What does the suffix '-itis' after an organ denote?

<p>Inflammation in that site (B)</p> Signup and view all the answers

How does inflammation respond to vascularized tissues?

<p>It delivers leukocytes and molecules of host defense to those tissues (A)</p> Signup and view all the answers

Why is inflammation described as a protective response?

<p>Because it is intended to eliminate the initial cause of cell injury and necrotic cells (C)</p> Signup and view all the answers

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