6 Questions
What is the primary goal of lipid therapy?
To reduce LDL-C levels
How is blood LDL-C concentration calculated using Friedwald's formula in mg/dL?
LDL-C (mg/dL) = TC - (HDL-C + TGS/5)
Which of the following conditions is not considered a coronary heart disease (CHD) equivalent?
Hypertension
What is the LDL-C goal for patients with coronary heart disease?
< 100 mg/dL
When should Friedwald's formula not be applied for LDL-C calculation?
When triglycerides (TGs) are above 400 mg/dL (4.5 mmol/L)
Which of the following is a risk factor for coronary heart disease when present with another risk factor?
Hypertension
Study Notes
LDL Cholesterol (LDL-C)
- LDL-C is considered a major atherogenic lipoprotein, and elevated levels are linked to the development of coronary heart disease, making it a key screening test for children with a family history of dyslipoproteinemia or coronary heart disease.
- LDL-C is the primary goal of lipid therapy.
Calculating LDL-C Concentration
- LDL-C concentration is calculated using Friedwald's formula: LDL-C (mg/dL) = TC - (HDL-C + TGS/5) or LDL-C (mmol/L) = TC - (HDL-C + TGS/2.2)
- Friedwald's formula is not applicable when triglycerides (TGs) level exceeds 400 mg/dL (4.5 mmol/L)
Interpreting LDL-C Results
For Patients with Coronary Heart Disease
- The LDL-C goal should be less than 100mg/dL for patients with coronary heart disease or coronary heart disease equivalent (peripheral arterial disease, abdominal aortic aneurysm, carotid artery disease, and diabetes mellitus)
For Patients with Two or More Risk Factors
- The LDL-C goal should be considered for patients with two or more of the following risk factors:
- Cigarette smoking
- Hypertension
- Low HDL-C
- Family history of premature CHD (in males first-degree relatives)
Learn about the relation between LDL-C and coronary heart disease, and its measurement as a screening test, especially in childhood.
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