Questions and Answers
What is the primary function of the stratum corneum?
Which layer contains keratohyalin granules and produces filaggrin?
How long does it typically take for keratinocytes to complete the epidermal turnover process?
What is true about the stratum spinosum?
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In psoriasis, what is the epidermal turnover rate?
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Study Notes
Layers of Skin
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Stratum Corneum:
- Outermost layer consisting of dead, flattened cells without nuclei.
- Primarily found on palms and soles, providing protection.
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Stratum Lucidum:
- A thin layer found only in specific areas such as palms and soles.
- Contains refractile granules of eleidin, contributing to skin resilience.
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Stratum Granulosum:
- Characterized by keratohyalin granules that produce filaggrin, essential for skin hydration.
- Contains lamellar granules (Odland bodies) that secrete lipids, helping in skin barrier formation.
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Stratum Spinosum:
- Rich in desmosomes, which facilitate the attachment of keratinocytes for structural integrity.
- Key site for keratin synthesis, contributing to skin strength.
- Highly mitotically active, promoting proliferation of skin cells.
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Stratum Basale (Stratum Germinativum):
- Innermost layer where active mitosis occurs, leading to generation of new keratinocytes.
- Site of attachment to the basement membrane and essential for epidermal regeneration.
Epidermal Turnover Time (ETT) / Skin Doubling Time
- Refers to the duration required for keratinocytes to migrate from the stratum Basale to shedding in the environment.
- Average ETT is approximately 8 weeks (42 – 75 days).
- In conditions like psoriasis, epidermal turnover is significantly expedited, occurring within just 4 days.
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Description
Test your knowledge on the five layers of skin, from the protective Stratum Corneum to the regenerative Stratum Basale. This quiz covers the characteristics and functions of each skin layer, enhancing your understanding of human anatomy.
