Human Anatomy: Skin and Hair Structure Quiz
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Questions and Answers

What type of keratin are nails composed of?

  • Hard keratin (correct)
  • Fibrous keratin
  • Soft keratin
  • Elastic keratin
  • Which part of the hair is responsible for its growth?

  • Hair shaft
  • Arrector pili
  • Hair bulb (correct)
  • Hair cortex
  • What is the primary function of sebaceous glands?

  • To protect against UV radiation
  • To provide insulation through hair
  • To lubricate and oil the skin (correct)
  • To produce sweat for cooling
  • Which type of hair is characterized as fine and short?

    <p>Vellus hair (D)</p> Signup and view all the answers

    What percentage of the body is covered with hair?

    <p>Everywhere except palms and soles (B)</p> Signup and view all the answers

    Which layer of skin is primarily responsible for sensations such as touch and temperature?

    <p>Dermis (A)</p> Signup and view all the answers

    What are the two main layers of the dermis?

    <p>Papillary and reticular (C)</p> Signup and view all the answers

    Which pigment is considered the most important in influencing skin color?

    <p>Melanin (D)</p> Signup and view all the answers

    The primary function of the epidermis is related to _____?

    <p>Protection (D)</p> Signup and view all the answers

    What term describes the deeper layer of skin that contains collagen and elastic fibers?

    <p>Dermis (A)</p> Signup and view all the answers

    Which type of tissue primarily makes up the epidermis?

    <p>Epithelial tissue (C)</p> Signup and view all the answers

    What is the role of fibroblasts in the dermis?

    <p>Synthesize collagen and elastin fibers (C)</p> Signup and view all the answers

    What does the term 'hypodermis' refer to?

    <p>The layer below the dermis (D)</p> Signup and view all the answers

    Which cells of the immune system are primarily responsible for detecting pathogens?

    <p>Neutrophils and Macrophages (D)</p> Signup and view all the answers

    What is the main function of interferons (IFNs) in the immune response?

    <p>Warn neighbouring cells of viral infection (B)</p> Signup and view all the answers

    Which of the following cytokines is considered a key anti-viral protein?

    <p>Interferons (C)</p> Signup and view all the answers

    What happens to neighbouring cells when they are exposed to interferons?

    <p>They establish an antiviral state (A)</p> Signup and view all the answers

    Which type of cells primarily secrete interleukins?

    <p>T-lymphocytes and Macrophages (D)</p> Signup and view all the answers

    How does a virus replication get inhibited in host cells?

    <p>By inducing active host proteins (D)</p> Signup and view all the answers

    Which characteristic is true about interleukins?

    <p>They are synthesized and secreted quickly after infection. (D)</p> Signup and view all the answers

    What role do TLRs play in the immune system?

    <p>They bind to components of microbes. (C)</p> Signup and view all the answers

    What is the primary function of antibodies in the immune system?

    <p>To bind specifically to unique antigenic epitopes (D)</p> Signup and view all the answers

    Which component of an antibody is responsible for binding the antigen?

    <p>Fab region (C)</p> Signup and view all the answers

    Which type of immunity is characterized by rapid responses to a broad range of microbes?

    <p>Innate immunity (A)</p> Signup and view all the answers

    What roles do T-cells play in the immune response?

    <p>They mediate cell-mediated responses (B)</p> Signup and view all the answers

    Which of the following structures make up the skin, which is part of the innate immune system?

    <p>Different layers of the skin (A)</p> Signup and view all the answers

    What determines the specificity of antigen binding in an antibody?

    <p>The Fab region's VH and VL sections (C)</p> Signup and view all the answers

    Which of the following does NOT belong to the external defenses of the innate immunity?

    <p>Phagocytic cells (D)</p> Signup and view all the answers

    What is a B-cell receptor (BCR)?

    <p>A membrane-bound antibody on a B-cell (B)</p> Signup and view all the answers

    What is the most dangerous type of skin cancer mentioned?

    <p>Melanoma (A)</p> Signup and view all the answers

    Which of the following is a characteristic used to recognize melanoma?

    <p>Border irregularity (C)</p> Signup and view all the answers

    What is the primary role of T-cells in the immune system?

    <p>Part of the specific immune response (B)</p> Signup and view all the answers

    Which component is NOT part of the innate immune system?

    <p>B-lymphocytes (A)</p> Signup and view all the answers

    What type of immunity involves a time lag before responding to a pathogen?

    <p>Adaptive immunity (A)</p> Signup and view all the answers

    Which of the following is a physical barrier in the immune system?

    <p>Skin (B)</p> Signup and view all the answers

    What is the function of normal flora in the immune system?

    <p>Compete with pathogens for nutrients and space (B)</p> Signup and view all the answers

    Which immune cells are primarily responsible for phagocytosis?

    <p>Neutrophils (C)</p> Signup and view all the answers

    What is one component of the internal defenses in the innate immune system?

    <p>Inflammatory response (C)</p> Signup and view all the answers

    Which of these is a characteristic of acquired immunity?

    <p>Development of memory (B)</p> Signup and view all the answers

    What percentage of true sweat is composed of water?

    <p>99% (C)</p> Signup and view all the answers

    Which type of sweat gland opens directly through pores?

    <p>Eccrine (merocrine) glands (B)</p> Signup and view all the answers

    In which burn classification does blistering occur?

    <p>Second-degree burns (B)</p> Signup and view all the answers

    What is a critical burn according to the rule of nines?

    <p>Over 10% of the body has third-degree burns (D)</p> Signup and view all the answers

    Which of the following is NOT a type of sweat gland mentioned?

    <p>Sebaceous glands (C)</p> Signup and view all the answers

    Flashcards

    Nails: What are they?

    Made of hard keratin, they grow from the nail matrix and are equivalent to the hooves and claws of other animals.

    What is a hair follicle?

    Hair follicles are produced from the epidermis and dermis, containing an epithelial cell bulb surrounding a papilla. It's responsible for the growth of hair.

    What are sebaceous glands?

    Sebaceous glands are found all over the body except the palms and soles. They produce sebum through holocrine secretion, which oils and lubricates the skin.

    What are sweat glands?

    Sweat glands are found all over the body except the nipples and part of the external genitalia. Their purpose is to cool the body down through sweat.

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    Describe the structure of a hair shaft.

    The medulla is the core of the hair, surrounded by the cortex. The cuticle is a single layer of overlapping cells.

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    Epidermis

    The outermost layer of skin, composed of epithelial tissue.

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    Dermis

    The deeper layer of skin, made of connective tissue, providing strength and flexibility.

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    Melanocyte

    A type of specialized cell in the epidermis that produces melanin, the pigment responsible for skin color.

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    Dermal Papillae

    Fingerprints, palmprints, and footprints are unique patterns formed by dermal papillae, which are projections of the dermis that elevate the epidermis.

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    Collagen

    Strong, fibrous protein found in the dermis, providing strength and resilience to skin.

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    Hypodermis

    The layer of fat and connective tissue beneath the dermis, anchoring the skin to underlying structures.

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    Temperature Regulation

    The process by which the skin helps to regulate body temperature, mainly through the dilation and constriction of blood vessels in the dermis.

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    Stratum Basale

    The layer of the epidermis where new skin cells are produced by mitosis.

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    Eccrine sweat gland

    A type of sweat gland that is most numerous and found all over the body. It releases a watery sweat composed mainly of water with some salts and traces of waste.

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    Apocrine sweat gland

    A type of sweat gland found in the axillary (armpit), anal, and genital areas. It releases a thicker, oily sweat that can decompose over time and cause body odor.

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    First-degree burn

    A type of burn that affects only the epidermis, the outermost layer of skin. It is characterized by redness and pain.

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    Second-degree burn

    A type of burn that affects the epidermis and dermis, the deeper layer of skin. This burn causes blistering, pain, and swelling.

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    Third-degree burn

    A type of burn that affects all three layers of skin: the epidermis, dermis, and hypodermis. It causes significant damage and often requires skin grafts.

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    What are neutrophils?

    White blood cells that are the first responders to infection, engulfing and destroying pathogens through phagocytosis.

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    What are macrophages?

    Large, long-lived immune cells that engulf pathogens and cellular debris through phagocytosis, acting as professional antigen-presenting cells.

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    What are Toll-like receptors (TLRs)?

    Pattern recognition receptors (PRRs) on the surface of immune cells that recognize specific molecular patterns found on pathogens, triggering an immune response.

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    What are Natural Killer (NK) cells?

    Lymphocytes that kill infected cells and tumor cells directly. They are part of the innate immune system and do not require prior sensitization.

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    What are lymphocytes?

    White blood cells that are responsible for adaptive immunity. They recognize specific antigens and mount a targeted response.

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    What are interferons (IFNs)?

    A type of cytokine that is produced by virus-infected cells to warn neighboring cells of an impending viral attack.

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    What are interleukins?

    A large group of cytokines that play a crucial role in regulating the immune response, influencing the behavior of other immune cells.

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    What is tumor necrosis factor (TNF)?

    A cytokine that plays a key role in inflammation, acting as a signaling molecule for immune cells and promoting cell death in infected or cancerous cells.

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    Innate Immunity

    The body's first line of defense against pathogens, working rapidly and broadly to protect against a wide range of microbes.

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    Acquired Immunity

    A highly specific and adaptable immune system, responding slowly but precisely to target specific microbes.

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    External Defenses

    Protective barriers like skin and mucous membranes that prevent pathogens from entering the body.

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    Internal Defenses

    Internal mechanisms like phagocytic cells, antimicrobial proteins, and the inflammatory response that fight off pathogens that have already entered the body.

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    Phagocytic Cells

    Specialized cells like neutrophils, macrophages, and NK cells that engulf and destroy invading pathogens. They are part of the innate immune system.

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    Antimicrobial Proteins

    Proteins like complement and interferons that help to fight off pathogens. They are part of the innate immune system.

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    Inflammatory Response

    A complex process that involves the release of chemical signals, recruitment of immune cells, and localized tissue damage. It helps to contain and clear infections.

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    Antibodies

    Specialized proteins produced by B-cells that can specifically bind to and neutralize antigens. They are a key component of the acquired immune system.

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    Adaptive Immunity

    An acquired, specific immune response that provides a second line of defense. It is slower, targets specific pathogens, and develops memory.

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    Neutrophils

    A type of white blood cell that engulf and destroy pathogens through phagocytosis. They are the most abundant WBCs and play a crucial role in the innate immune system.

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    Phagocytosis

    The process by which certain cells (e.g., neutrophils, macrophages) engulf and destroy pathogens. It is a key mechanism of the innate immune system.

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    Antigen

    Any substance that is capable of triggering an immune response. It is recognized by the immune system as foreign.

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    B-lymphocytes

    A type of white blood cell that plays a key role in the adaptive immune response. They produce antibodies, which bind to and neutralize specific antigens.

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    T-lymphocytes

    A type of white blood cell that plays a key role in the cellular response of adaptive immunity. They directly kill infected cells and regulate other immune cells.

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    Complement System

    A complex system of proteins that helps to fight infections by marking pathogens for destruction and triggering inflammation. It is an essential component of the innate immune system.

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    Immunodeficiency

    A state in which the body's immune system is weakened or impaired, making it more susceptible to infections and diseases.

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    Study Notes

    Integumentary System

    • The integumentary system includes skin, hair, fingernails, and sweat and oil glands.
    • The skin has multiple layers to protect the body, regulate temperature, and excrete waste.
    • The skin is the first barrier against harmful things, and keeps good things within the body.

    Functions of Skin

    • Protection: Protects underlying tissues and organs.
    • Vitamin D synthesis: Synthesizes vitamin D with UV exposure.
    • Homeostasis: Helps regulate body temperature.
    • Sensory reception: Contains nerve endings for sensory input.

    Epithelium: Layers and Cell Types

    • Stratum corneum: Top layer, composed of dead, flattened keratinized cells.
    • Stratum granulosum: Layer below, cells are flattening and organelles are deteriorating.
    • Stratum spinosum: Contains thick bundles of intermediate filaments.
    • Stratum basale: Bottom layer, stem cells actively divide forming more superficial layers.
    • Keratinocytes: Major cells in epidermis; produce keratin
    • Desmosomes: Cell junctions that connect keratinocytes.
    • Melanocytes: Produce melanin, a pigment that protects against UV light.
    • Langerhans' cells: Part of the immune system
    • Merkel cells: Sensory cells.

    Dermis

    • Strong, flexible connective tissue; your "hide".
    • Contains fibroblasts, macrophages, mast cells, and WBCs.
    • Fiber types include collagen (strength), elastic (stretch), and reticular fibers.
    • Rich supply of nerves and vessels.
    • Two layers:
      • Papillary layer (areolar connective tissue; dermal papillae).
      • Reticular layers (network of collagen and reticular fibers).
    • Important in temperature regulation.

    Appendages of Skin

    • Hair, hair follicles
    • Sebaceous (oil) glands
    • Sweat glands (sudoiferous)
    • Nails

    Skin Appendages

    • Derived from epidermis, extending into the dermis.
    • Include; hair and hair follicles, sebaceous (oil) glands, sweat (sudoiferous) glands, nails

    Fingerprints, Palmprints, Footprints

    • Dermal papillae create ridges in the epidermis.
    • They are elevated by the epidermal ridges.
    • Characterized by sweat pores
    • Genetically determined.
    • Flexion creases originate from dermal folding.
    • Fibrous structures provide strength and resilience to the skin.

    Hypodermis

    • Also called superficial fascia.
    • Consists of fatty tissue (areolar tissue and adipose cells).
    • Stores fat and anchors skin.
    • Contains different patterns of fat accumulation.

    Skin Color

    • Three main pigments:
      • Melanin (most important, produced by melanocytes).
      • Carotene (from carrots, yellow vegetables).
      • Hemoglobin (contributes to light skin color).
    • Melanin granules are passed to keratinocytes in the stratum basale; digested by lysosomes.
    • Variations in color influenced by the amount of each pigment.

    Nails

    • Of hard keratin.
    • Corresponds to hooves and claws.
    • Grows from nail matrix.

    Hair and Hair Follicles

    • Present everywhere except palms, soles, nipples, and parts of genitalia.
    • Each hair has an arrector pili muscle (smooth muscle).
    • Contains hair bulb with epithelial cells and hair papilla (connective tissue).

    Functions of Hair

    • Provides warmth.
    • Senses light touch.
    • Protects the scalp.
    • Consists of three concentric layers: medulla, cortex, and cuticle.

    Types of Hair

    • Vellus (fine, short hairs).
    • Intermediate hairs.
    • Terminal (longer, coarser hairs).

    Hair Growth

    • Averages 2 mm/week.
    • Active growth phase
    • Resting phase, hair is shed

    Hair Loss

    • Thinning: Age related.
    • Male pattern baldness.

    Hair color

    • Determined by the amount of melanin and how it's distributed.

    Sebaceous (Oil) Glands

    • Located throughout the body except on palms and soles.
    • Produce sebum (oils) through holocrine secretion.
    • Sebum lubricates and conditions skin.

    Sweat Glands

    • Cover entire skin surface, except nipples and parts of genitalia
    • Produce sweat (mostly water, salts).
    • Important for temperature regulation.
    • Humans are most efficient at sweating among mammals.

    Types of Sweat Glands

    • Merocrine (or eccrine): Most numerous, open directly onto the skin surface.
    • Apocrine: Found in axillary, anal, and genital regions; ducts open into hair follicles.
    • Sweat has an odor due to organic compounds.
    • Modified apocrine glands include ceruminous (earwax), mammary (milk).

    Disorders of the Integumentary System

    • Burns:
      • Threat to life
      • Catastrophic loss of body fluids
      • Dehydration and shock
    • Infections: First-degree (epidermis only): Redness Second-degree (epidermis and upper dermis): Blisters Third-degree (full thickness): Destruction
    • Wounds: Direct contact, vector-borne

    Skin Cancer

    • Skin cancer related to UV exposure and aging
    • Benign tumors (e.g., warts)
    • Malignant tumors:
    • Actinic keratosis
    • Basal cell carcinoma
    • Squamous cell carcinoma
    • Malignant melanoma (most dangerous, recognition A,B,C,D)

    Immune System

    • A functional system, not an organ system
    • Includes; skin (physical barrier), lining of mucus membranes (physical barrier), secretions (tears, mucus, etc) antimicrobial, blood cells and vasculature (WBCs), bone marrow, liver (makes complement proteins), lymphatic system, and lymphoid organs (most tissues and resident immune cells).

    Overview of Immune System

    • Innate: First line of defense, no time lag, not antigen specific, no memory
    • Adaptive: Second line of defense, lag period, antigen specific, development of memory

    A Typical Immune Response

    • External defenses: Skin, mucous membranes, secretions prevent invading microbes from entering the body.
    • Internal defenses: Phagocytic cells, antimicrobial proteins, inflammatory response, natural killer cells, and complement work within the body to combat the invasion of microbes.

    Innate vs Adaptive Immunity

    • Innate immunity: Rapid response; no time lag; not antigen specific; no memory
    • Adaptive immunity: Slower response; time lag; antigen specific; memory

    Anatomical Barriers (Mechanical)

    • Skin: Physical barrier to pathogens and chemicals
    • Mucociliary escalator: Protects the respiratory tract.
    • Flushing actions: Fluids like saliva, tears, and urine wash away pathogens.

    Anatomical Barriers (Chemical)

    • Skin secretions like sebum, sweat, and tears
    • Enzymes and other chemicals in bodily secretions can effectively inhibit pathogens
    • Stomach acid
    • Lysozyme

    Anatomical Barriers (Biological)

    • Normal flora: Microbes in many bodily areas act as competition against incoming pathogens
    • Normal flora prevent or limit infection

    Innate Immune System: Internal Defenses - Cellular

    • Neutrophils: Most abundant WBC; efficient phagocytes.
    • Monocytes/Macrophages: Migrate to tissues and phagocytose microbes; antigen presentation
    • Natural Killer (NK) Cells: Kill virus-infected cells and cancer cells.
    • Toll-like receptors (TLRs): Proteins that recognize and bind to pathogens or their components.

    Innate Immune System: Internal Defenses – Extracellular

    • Cytokines: Signaling molecules secreted by immune cells to regulate the immune response.
    • Complement: a large number of plasma proteins that react with one another (C1 - C9).
    • Coagulation proteins: Mechanisms to stop bleeding after injury to blood vessels, complex pathway with platelets, coagulation factors, vitamin k.

    Cytokines

    • Small signaling proteins.
    • Secreted by immune cells to regulate behavior of other immune cells.
    • Key regulators in both innate and adaptive immunity.
    • Key players: interferons, interleukins, tumor necrosis factor (TNF).

    Immunoglobulins(Antibodies).

    • Produced by plasma cells.
    • Part of adaptive immunity.
    • Specific binding sites to unique antigenic epitopes.
    • Exist in two forms: soluble and membrane-bound (B-cell receptor).

    Specific Response - Adaptive Immunity

    • Antibody-antigen relationship
    • Involves lymphocytes (B and T cells) and plasma cells
    • Basis of vaccines

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    Test your knowledge on the anatomy of skin and hair in this informative quiz. Explore key components such as keratin, sebaceous glands, and the layers of the dermis. Perfect for students and enthusiasts of human biology.

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