Module 2_Unit 2 (Part 2)

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Questions and Answers

What does the abnormal result of the BSP dye test indicate?

  • Normal biliary obstruction
  • Decrease in lipids synthesis
  • Defective hepatic blood flow (correct)
  • Normal liver function

Which substances may be assessed through prothrombin time and partial thromboplastin time in patients with cirrhosis?

  • Lipids & lipoproteins
  • Some coagulation factors (correct)
  • Albumin
  • Serum total protein

What is indicated by an increased concentration of serum bilirubin and bile acids in circulation?

  • Improvement in liver excretory function
  • Normal liver function
  • Impaired metabolic liver function (correct)
  • Enhanced liver metabolism

Which of the following substances is NOT metabolized in the liver?

<p>Caffeine (A)</p> Signup and view all the answers

What is the purpose of the Indocyanine Green clearance test?

<p>Determination of rate of exogenous substance clearance (C)</p> Signup and view all the answers

What may decreased levels of lipids & lipoproteins in cirrhosis patients indicate?

<p>Decreased synthesis of lipids (D)</p> Signup and view all the answers

Which test is used for the measurement of rate of exogenous substance clearance for substances like aminopyrine, lidocaine, and caffeine?

<p>Rose Bengal dye determination (A)</p> Signup and view all the answers

What is a possible indication when there is a decrease in serum total protein and albumin in cirrhosis patients?

<p>Impaired production due to decreased synthesis (B)</p> Signup and view all the answers

Which enzyme is specifically mentioned to be high in hepatocytes and can leak into plasma in cases of liver injury?

<p>Alanine aminotransferase (ALT) (B)</p> Signup and view all the answers

What is the principle behind the determination of serum cholesterol levels?

<p>Esterification of cholesterol in the liver (A)</p> Signup and view all the answers

Which test measures the rate of excretion following ingestion/intravenous injection of galactose?

<p>Galactose tolerance test (A)</p> Signup and view all the answers

Which enzyme is associated with altered lipoprotein metabolism in patients with liver obstructive disease?

<p>Lipoprotein X (A)</p> Signup and view all the answers

Which enzyme is critical in determining the cellular location and patterns of enzyme change in various types of liver disease?

<p>Gamma-glutamyl transferase (GGT) (B)</p> Signup and view all the answers

What type of metabolism test can be useful for diagnosis and monitoring of liver damage?

<p>Carbohydrate metabolism tests (A)</p> Signup and view all the answers

In drug metabolism, what is measured to determine the rate of metabolism?

<p><em>Aminopyrine</em> labelled with radioactive carbon in breath (D)</p> Signup and view all the answers

Which of the following is NOT a common cause of jaundice in Gilbert Syndrome?

<p>Increased excretion of bilirubin (B)</p> Signup and view all the answers

What is the half-life of LD (LD 4 and 5)?

<p>4-6 hours (C)</p> Signup and view all the answers

What is the most common cause of jaundice in adolescence or early adulthood?

<p>Gilbert Syndrome (B)</p> Signup and view all the answers

Which condition is associated with elevated levels of Alpha-fetoprotein (AFP)?

<p>Acute hepatic injury (A)</p> Signup and view all the answers

Which type of bilirubin is typically elevated in Gilbert Syndrome?

<p>Unconjugated bilirubin (C)</p> Signup and view all the answers

Which type of liver disease is Anti-mitochondrial antibody commonly associated with?

<p>Primary biliary cirrhosis (D)</p> Signup and view all the answers

What is the effect of insertion of an extra TA sequence in the UGT1A1 promoter in Gilbert Syndrome?

<p>Decrease in expression of UGT1A1 gene (B)</p> Signup and view all the answers

What is the main diagnostic importance of Alpha-fetoprotein (AFP) testing?

<p>Detection of hepatocellular carcinoma (B)</p> Signup and view all the answers

Which of the following is a feature that helps distinguish Gilbert Syndrome from chronic hepatitis?

<p>Presence of bilirubin in urine (C)</p> Signup and view all the answers

Which gender has a higher incidence of Anti-mitochondrial antibody-related liver disease?

<p>Females (B)</p> Signup and view all the answers

What is the primary method used in laboratory testing to measure bilirubin levels in Gilbert Syndrome?

<p>Measurement in a fasting state (D)</p> Signup and view all the answers

Which type of liver condition involves destruction of both intrahepatic and extrahepatic ducts?

<p>Primary sclerosing cholangitis (B)</p> Signup and view all the answers

Why are individuals with Gilbert Syndrome predisposed to acetaminophen toxicity?

<p>Reduced expression of UGT1A1 gene (D)</p> Signup and view all the answers

Which liver disease is characterized by fibrosis of bile canaliculi, collagen production, and necrosis?

<p>Primary biliary cirrhosis (A)</p> Signup and view all the answers

What is a distinguishing characteristic of unconjugated hyperbilirubinemia seen in Gilbert Syndrome?

<p>Normal function of UGT1A1 gene (D)</p> Signup and view all the answers

Which enzyme has the longest half-life among the options provided?

<p>GGT (D)</p> Signup and view all the answers

What is the main cause of jaundice in newborn babies as discussed in the text?

<p>Deficiency in glucuronyl transferase enzyme (C)</p> Signup and view all the answers

Why are premature infants more susceptible to jaundice related to unconjugated bilirubin?

<p>They are born without the glucuronyl transferase enzyme (B)</p> Signup and view all the answers

How does exposure to pregnanediol and NEFA in breastmilk contribute to jaundice in newborns?

<p>They compete for binding sites of albumin (B)</p> Signup and view all the answers

What is the consequence of high levels of unconjugated bilirubin build-up in newborns?

<p>Kernicterus and cell damage (D)</p> Signup and view all the answers

Why is ultraviolet radiation used as a treatment for jaundice in newborns?

<p>To convert bilirubin into a more water-soluble form (D)</p> Signup and view all the answers

How does beta-glucuronidase in meconium contribute to jaundice development in newborns?

<p>It hydrolyzes bilirubin conjugates to unconjugated bilirubin (B)</p> Signup and view all the answers

What role does aspirin ingestion play in increasing the risk of kernicterus in newborns?

<p>It competes for binding sites of albumin with bilirubin (D)</p> Signup and view all the answers

What is the mechanism by which exchange transfusion helps in treating extreme cases of jaundice in newborns?

<p>It rapidly removes unconjugated bilirubin from circulation (C)</p> Signup and view all the answers

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