18 Questions
What regulates melanocyte differentiation?
MITF
Which enzyme catalyzes the conversion of Tyrosine to DOPA within the melanosome?
Tyrosinase (Tyr)
What happens in individuals with a mutation in the gene for tyrosinase?
Less melanin production
Which skin condition is characterized by autoimmune loss of melanocytes?
Vitiligo
Where does the synthesis of Vitamin D3 occur?
Keratinocytes
What is responsible for the formation of the epidermal permeability barrier?
Cell junctions
What is the primary role of Langerhans cells in the immune response?
Recognizing and presenting antigens to the immune system
Which type of cells are Langerhans cells derived from?
Bone marrow-derived dendritic cells
How do Langerhans cells interact with keratinocytes?
Via E-cadherin association
What is the main function of keratinocytes in the epidermis?
Form the epidermal permeability barrier
Which process leads to the production of Vitamin D3 in the skin?
Exposure to UV radiation
What is the primary source of melanin production in the skin?
Keratinocytes
What is the main function of the epidermal permeability barrier?
Prevent dehydration
Which of the following is NOT a function of the skin?
Vitamin C synthesis
What is the main component produced by melanocytes in the skin?
Melanin
Which layer of the skin is responsible for the synthesis of Vitamin D3?
Epidermis
What is the primary role of Langerhans cells in the skin?
Immunity
Which type of junctions are present between cells in the skin?
Desmosomes
Explore how Langerhans cells, a type of intraepidermal macrophages, contribute to immunity by recognizing and presenting antigens to the immune system, engaging in phagocytosis, and playing roles in allergy and chronic skin inflammation.
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