Langerhans Cells and Immunity
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Questions and Answers

What regulates melanocyte differentiation?

  • Melanosomes
  • Keratinocytes
  • MITF (correct)
  • Tyrosinase enzymes

Which enzyme catalyzes the conversion of Tyrosine to DOPA within the melanosome?

  • Tyrosinase (Tyr) (correct)
  • Phenylalanine hydroxylase
  • MITF
  • Keratinocytes

What happens in individuals with a mutation in the gene for tyrosinase?

  • Less melanin production (correct)
  • Increased melanin production
  • Enhanced keratinocyte maturation
  • Vitiligo development

Which skin condition is characterized by autoimmune loss of melanocytes?

<p>Vitiligo (C)</p> Signup and view all the answers

Where does the synthesis of Vitamin D3 occur?

<p>Keratinocytes (D)</p> Signup and view all the answers

What is responsible for the formation of the epidermal permeability barrier?

<p>Cell junctions (C)</p> Signup and view all the answers

What is the primary role of Langerhans cells in the immune response?

<p>Recognizing and presenting antigens to the immune system (A)</p> Signup and view all the answers

Which type of cells are Langerhans cells derived from?

<p>Bone marrow-derived dendritic cells (B)</p> Signup and view all the answers

How do Langerhans cells interact with keratinocytes?

<p>Via E-cadherin association (A)</p> Signup and view all the answers

What is the main function of keratinocytes in the epidermis?

<p>Form the epidermal permeability barrier (A)</p> Signup and view all the answers

Which process leads to the production of Vitamin D3 in the skin?

<p>Exposure to UV radiation (B)</p> Signup and view all the answers

What is the primary source of melanin production in the skin?

<p>Keratinocytes (D)</p> Signup and view all the answers

What is the main function of the epidermal permeability barrier?

<p>Prevent dehydration (C)</p> Signup and view all the answers

Which of the following is NOT a function of the skin?

<p>Vitamin C synthesis (C)</p> Signup and view all the answers

What is the main component produced by melanocytes in the skin?

<p>Melanin (A)</p> Signup and view all the answers

Which layer of the skin is responsible for the synthesis of Vitamin D3?

<p>Epidermis (D)</p> Signup and view all the answers

What is the primary role of Langerhans cells in the skin?

<p>Immunity (C)</p> Signup and view all the answers

Which type of junctions are present between cells in the skin?

<p>Desmosomes (C)</p> Signup and view all the answers

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