Lactose as a Pharmaceutical Excipient
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Questions and Answers

What is the main disadvantage of lactose mentioned in the text?

  • Reducing properties affecting stability of tablets
  • Chemical reactions towards amines (correct)
  • Lactose intolerance in some patients
  • Hygroscopic nature leading to moisture uptake

    • How is spray-dried lactose produced?

  • Using a powder aerosol process (correct)
  • Forming coarse particles through a slow drying process
  • Mixing liquid lactose with a hot drying chamber
  • Spraying liquid lactose solution into a cold drying chamber

    • How does crystalline lactose differ from modified lactose like spray dry lactose?

  • Modified lactose is obtained through sieving
  • Modified lactose has ordered crystals
  • Crystalline lactose is in amorphous form and softer
  • Crystalline lactose is stronger and harder but less compressible (correct)

    • How is milled lactose different from sieved lactose?

    <p>Differ in both particle size and morphology</p> Signup and view all the answers

    What property of lactose makes it unsuitable for direct compression into tablets?

    <p>It is not directly compressible</p> Signup and view all the answers

    Why is agglomerated lactose more prone to Maillard reactions compared to other types?

    <p>It has higher chemical reactivity</p> Signup and view all the answers

    What is the main issue associated with spray-dried lactose?

    <p>Excessive moisture content</p> Signup and view all the answers

    What is the key difference between crystalline α-lactose monohydrate and crystalline β-lactose monohydrate?

    <p>Maillard reaction rate</p> Signup and view all the answers

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