5 Questions
What is the hypothesized anchoring site for Lf on the surface of Gram-negative bacteria?
Porins
How does Lf influence the release of LPS from bacteria?
By chelating iron
What does Bovine Lf inhibit the integrin-mediated internalization of into host cells through its binding to?
Viral polypeptides II and III
What does Lf limit in order to prevent septic shock associated with bacterial infections?
Production of pro-inflammatory cytokines
What does the chelation of iron by apoLf during inflammation help prevent?
Formation of hydroxyl radicals
Test your knowledge about the binding of lactoferrin on Gram-negative bacteria and its potential mechanisms such as binding to lipid-A moiety, negative charges in the inner core of LPS, and porins. Explore how lactoferrin's iron chelation properties may compete with the iron acquisition systems of pathogens.
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