20 Questions
Where does the Krebs cycle take place?
Mitochondria of eukaryotes and the cytosol of prokaryotes
What is the initial product of the oxidation of pyruvate by pyruvate dehydrogenase complex?
Acetyl-coa
Which compound combines with acetyl-coa to initiate the Krebs cycle?
Oxaloacetate
What is the final product of the Krebs cycle?
Oxaloacetate
How many times does the Krebs cycle run for each glucose molecule?
Twice
What is the main purpose of NADH and FADH2 produced in the Krebs cycle?
Used in the electron transport chain to generate ATP
What is the main purpose of the Krebs cycle?
To produce ATP and electron carriers
What is the role of NADH produced in the Krebs cycle?
It is used in the electron transport chain to generate ATP
What is the initial product of the oxidation of pyruvate by pyruvate dehydrogenase complex?
Acetyl-coa
What is the end product of the Krebs cycle?
Carbon dioxide
Which compound combines with oxaloacetate to initiate the Krebs cycle?
Acetyl-coa
What is the main function of FADH2 produced in the Krebs cycle?
To be used in the electron transport chain to produce ATP
Where does the Krebs cycle take place in eukaryotic cells?
Mitochondria
What is the carbon compound formed when acetyl-coa combines with oxaloacetate to initiate the Krebs cycle?
Citrate
What is the compound that is converted into malate and then oxaloacetate, reducing NAD+ to NADH in the Krebs cycle?
Fumarate
What is the total number of NADH produced from one molecule of glucose in the Krebs cycle?
Six
Which compound is formed by the conversion of alpha-ketoglutarate, producing NADH and carbon dioxide in the Krebs cycle?
Succinyl-CoA
What is the end product of the conversion of succinyl-CoA, which generates GTP in the Krebs cycle?
Malate
What is the compound formed when pyruvate is oxidized into acetyl-coa by pyruvate dehydrogenase complex, producing a molecule of NADH and carbon dioxide in the Krebs cycle?
Acetyl-coa
Which compound combines with oxaloacetate to form citrate, initiating the Krebs cycle?
Acetyl-coa
Study Notes
- The Krebs cycle, also known as the tricarboxylic acid cycle, is a biochemical pathway that generates energy through the oxidation of acetyl-coa and produces NADH and amino acids.
- Takes place in the mitochondria of eukaryotes and the cytosol of prokaryotes.
- Pyruvate derived from glucose through glycolysis, split into two pyruvate molecules.
- Pyruvate is oxidized into acetyl-coa by pyruvate dehydrogenase complex, producing a molecule of NADH and carbon dioxide.
- Acetyl-coa combines with oxaloacetate to form citrate, a six carbon compound.
- Citrate is isomerized into isocitrate, then oxidized into alpha-ketoglutarate, producing NADH and carbon dioxide.
- Alpha-ketoglutarate is converted into succinyl-CoA, producing NADH and carbon dioxide.
- Succinyl-CoA is converted into fumarate, generating GTP.
- Fumarate is converted into malate, then oxaloacetate, reducing NAD+ to NADH.
- One molecule of glucose results in the production of six NADH, two FADH2, one GTP, and four carbon dioxide.
- All NADH and FADH2 are used in the electron transport chain to generate ATP.
- Glucose split into two pyruvate, so the cycle runs twice for each glucose molecule.
Test your knowledge of the Krebs cycle, a crucial biochemical pathway for energy production in living organisms. Learn about the oxidation of acetyl-coa, NADH and amino acid production, and the overall process taking place in the mitochondria of eukaryotes and the cytosol of prokaryotes.
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