Knudson 2-Hit Model Quiz

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Questions and Answers

Which gene is associated with familial breast cancer and ovarian cancer?

  • NF1
  • BRCA1 (correct)
  • CDKN2A
  • RB1

Which gene is associated with Retinoblastoma, a pediatric tumor of the eye?

  • APC
  • TP53
  • NF1
  • RB1 (correct)

What is the cellular behavior exhibited by mutations in cancer susceptibility according to the text?

  • Dominant behavior
  • Recessive behavior (correct)
  • Incomplete dominance
  • Co-dominant behavior

What contributes to the progression of tumors according to the text?

<p>Chromosome Integrity (A)</p> Signup and view all the answers

What is the role of inherited mutations in cancer according to the Knudson 2-Hit Model?

<p>Inherited mutations predispose individuals to cancer but do not cause the disease on their own (A)</p> Signup and view all the answers

What is the impact of a single mutation in tumor suppressor genes?

<p>Brings individuals one step closer to cancer (C)</p> Signup and view all the answers

What is required for cancer development in the Knudson 2-Hit Model?

<p>Two random mutations in one cell (B)</p> Signup and view all the answers

What is the function of the APC mutation in colorectal cancer development?

<p>Down-regulates ß-catenin, myc signal transduction (A)</p> Signup and view all the answers

What is necessary for a complete loss of functional protein in DNA repair genes?

<p>A 'second hit' on the healthy allele (A)</p> Signup and view all the answers

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