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Questions and Answers
What is the therapeutic class of Ketoconazole?
What is the therapeutic class of Ketoconazole?
What is the pharmacologic class of Ketoconazole?
What is the pharmacologic class of Ketoconazole?
What are the primary indications for Ketoconazole?
What are the primary indications for Ketoconazole?
First choice for blastomycosis, histoplasmosis, paracoccidioidomycosis, and sporotrichosis; Second choice after amphotericin B for aspergillosis, candidiasis, and coccidioidomycosis.
How does Ketoconazole act on fungal cells?
How does Ketoconazole act on fungal cells?
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What are common side effects of Ketoconazole?
What are common side effects of Ketoconazole?
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What are notable adverse drug interactions with Ketoconazole?
What are notable adverse drug interactions with Ketoconazole?
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What patient teaching is advised for those taking Ketoconazole?
What patient teaching is advised for those taking Ketoconazole?
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What nursing implications should be noted for Ketoconazole?
What nursing implications should be noted for Ketoconazole?
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Study Notes
Ketoconazole Overview
- Therapeutic class: Antifungal, primarily used to treat various fungal infections.
- Pharmacologic class: Imidazole derivative, affecting fungal metabolism and cell structure.
Indications
- First-line treatment for:
- Blastomycosis
- Histoplasmosis
- Paracoccidioidomycosis
- Sporotrichosis
- Second-line treatment (after amphotericin B) for:
- Aspergillosis
- Candidiasis
- Coccidioidomycosis
Mechanism of Action
- Inhibits ergosterol synthesis, crucial for fungal cell membrane integrity.
- Increased permeability of the cell wall leads to osmotic instability, resulting in fungal cell death.
Side Effects
- Potential for serious side effects:
- Cardiac suppression
- Liver injury
- Common gastrointestinal upset, such as nausea
Adverse Drug Interactions
- Inhibits CYP3A4 enzyme, affecting metabolism of co-administered drugs.
- Antacids, anticholinergics, or H2 antagonists can reduce absorption if gastric pH is elevated.
Patient Education
- Advise waiting at least 2 hours after dosing before taking antacids or similar drugs.
- Nausea is a typical side effect and will usually improve over time.
- Patients should be instructed to report any cardiac symptoms immediately.
Nursing Responsibilities
- Regular monitoring of liver function tests is crucial to detect possible liver injury.
- Keep track of medications metabolized by CYP3A4 to avoid harmful interactions.
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Description
Test your knowledge of Ketoconazole with these flashcards! Covering therapeutic and pharmacologic classifications, indications, and actions, this quiz will help you understand this important antifungal medication. Perfect for students in pharmacology or healthcare-related fields.
