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Questions and Answers
What is the main function of keratins in epithelial tissues such as the epidermis?
What is the main function of keratins in epithelial tissues such as the epidermis?
To impart structural integrity and resistance against mechanical stressors
How many mammalian keratin genes have been identified to date?
How many mammalian keratin genes have been identified to date?
More than 50
What is a characteristic feature of epidermal keratin expression?
What is a characteristic feature of epidermal keratin expression?
Limited to specific compartments of the epidermis and certain anatomical regions
What is the resulting disorder when keratin 2e mutations disrupt filament assembly?
What is the resulting disorder when keratin 2e mutations disrupt filament assembly?
What is the primary cause of excessive callus formation in the disorder described in the text?
What is the primary cause of excessive callus formation in the disorder described in the text?
Which keratin is specifically expressed in the palms of the hands and soles of the feet?
Which keratin is specifically expressed in the palms of the hands and soles of the feet?
What type of keratins are expressed in highly stressed regions such as the palms and the soles, and what disorder is associated with mutations in these keratins?
What type of keratins are expressed in highly stressed regions such as the palms and the soles, and what disorder is associated with mutations in these keratins?
Which keratins are specifically found in the intestine and oral mucosa?
Which keratins are specifically found in the intestine and oral mucosa?
What is the consequence of keratin mutations disrupting filament assembly in the epidermis?
What is the consequence of keratin mutations disrupting filament assembly in the epidermis?
What is the characteristic feature of hard keratins found in hair?
What is the characteristic feature of hard keratins found in hair?
What is the condition caused by dysfunction of the hard keratins in hair, and what are the symptoms of this condition?
What is the condition caused by dysfunction of the hard keratins in hair, and what are the symptoms of this condition?
What is the origin of the name 'monilethrix'?
What is the origin of the name 'monilethrix'?
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