Keppra Overview and Uses

Questions and Answers

What are other names for Keppra?

Elepsia (correct)

Carbamazepine

Phenobarbital

Levetiracetam (correct)

What is the therapeutic class of Keppra?

Anticonvulsant

What is a rare use of Keppra?

Subarachnoid hemorrhage

Keppra is used in the treatment of ______ seizures.

myoclonic, partial onset, primary generalized tonic-clonic Signup and view all the answers

What are some unlabeled uses of Keppra?

migraines, bipolar, new-onset pediatric epilepsy Signup and view all the answers

What is the maximum daily dose of Keppra?

3000 mg/day Signup and view all the answers

Common dosage forms of Keppra include ______.

tablet (extended release-Keppra XR), IR tablet, oral solution, IV solution injection Signup and view all the answers

What is the starting dosage for adult partial seizures?

500 mg PO/IV q12h Signup and view all the answers

Match the following dosages with their conditions:

Partial seizures = 500-1500 mg PO/IV q12h Juvenile myoclonic epilepsy = 1500 mg PO/IV q12h Primary generalized tonic-clonic seizures = 1500 mg PO/IV q12h Renal dosing = Adjust dose amount and frequency Signup and view all the answers

Study Notes

Keppra (Levetiracetam) Overview

Also known as Levetiracetam and Elepsia.
Classified as an anticonvulsant.

Therapeutic Uses

Primarily used to control seizures related to epilepsy.
Effective for:
- Myoclonic seizures
- Partial onset seizures
- Primary generalized tonic-clonic seizures
Rarely used for subarachnoid hemorrhage.

Unlabeled Uses

Utilized off-label to treat:
- Migraines
- Bipolar disorder
- New-onset pediatric epilepsy
In Europe, highly effective as monotherapy for partial seizures.

Dosage Information

Available in several forms:
- Extended-release tablet (Keppra XR)
- Immediate-release tablet
- Oral solution
- IV solution injection
Maximum daily dosage is 3000 mg.

Adult Dosing Guidelines

Pediatric and adult dosing employs various formulations:
- Partial seizures, adjunct treatment: Start at 500 mg PO/IV every 12 hours; can increase by 1000 mg/day every two weeks.
- Juvenile myoclonic epilepsy, adjunct treatment: Start at 500 mg PO/IV every 12 hours; increase similarly with a maximum of 3000 mg/day.
- Primary generalized tonic-clonic seizures, adjunct treatment: Same starting and dosing increase protocols as above.
For renal dosing, adjust according to creatinine clearance (CrCl):
- CrCl 50-80: 500-1000 mg every 12 hours
- CrCl 30-50: 250-750 mg every 12 hours
Important to avoid cutting, crushing, or chewing tablets and to taper doses gradually when discontinuing.

Description

This quiz covers the overview and therapeutic uses of Keppra (Levetiracetam), an anticonvulsant used primarily for seizure control in epilepsy. It includes information on dosage forms, adult dosing guidelines, and some off-label uses. Test your knowledge about this essential medication and its applications.