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Questions and Answers

What kind of memory deficit did Patient HM experience after the removal of his hippocampus?

  • Retrograde semantic memory deficit
  • Enhanced ability to memorize new events
  • Partial anterograde semantic memory deficit
  • Complete anterograde episodic memory deficit (correct)

Which part of the brain was removed from Patient HM, leading to memory impairment?

  • Occipital lobe
  • Medial temporal lobe (correct)
  • Parietal lobe
  • Frontal lobe

What type of memory was spared in Patient HM despite the memory deficit for events?

  • Semantic memory
  • Episodic memory
  • Procedural memory (correct)
  • Working memory

What was the impact of the surgery on Patient HM's ability to memorize new events?

<p>Impairment in memorizing new events (D)</p> Signup and view all the answers

What deficit did Patient HM experience in recalling events that had occurred up to three years before the surgery?

<p>Partial retrograde memory deficit (B)</p> Signup and view all the answers

Which structure could play a central role in the encoding of episodic memories?

<p>Amygdala (D)</p> Signup and view all the answers

What is the standard theory of episodic memory consolidation proposed by Larry Squire?

<p>Slow consolidation process leading to neocortical storage becoming stand alone (B)</p> Signup and view all the answers

What did Meunier et al. (1993) find about the deficit caused by rhinal lesions?

<p>Perirhinal cortex explains most of the deficit caused by rhinal lesions (D)</p> Signup and view all the answers

What contributes equally to memory formation according to the findings?

<p>Amygdala and Hippocampus (B)</p> Signup and view all the answers

What is spared in terms of memory formation regarding patient HM?

<p>Semantic memory (B)</p> Signup and view all the answers

What is the primary function of the hippocampus in relation to memory?

<p>Encoding fast incidental conjunctions between very different stimulus representations (C)</p> Signup and view all the answers

What does CA1 in the hippocampus do in the memory retrieval process?

<p>Receives random code from CA3 and links to cortical input pattern (A)</p> Signup and view all the answers

What is the main role of the cortex in memory formation?

<p>Contributing to the slow, incremental formation of conjunctions between similar stimuli (D)</p> Signup and view all the answers

Which part of the hippocampus is responsible for generating random codes due to diffuse cortical projections?

<p>CA3 (D)</p> Signup and view all the answers

What is the significance of the activation pattern in CA1 for memory retrieval?

<p>It becomes linked to cortical input pattern and is instrumental for memory retrieval (A)</p> Signup and view all the answers

What is one of the main conclusions of the multiple-trace theory?

<p>Hippocampal codes provide necessary indexes for different memories (B)</p> Signup and view all the answers

What is a key role of the hippocampus according to the multiple-trace theory?

<p>Orchestrating cortical binding and indexing (D)</p> Signup and view all the answers

What happens during post-exploration sleep according to Wilson and McNaughton's experiment?

<p>Re-activation of the correlation pattern observed during the explorative behavior period (A)</p> Signup and view all the answers

What does the experiment by Hoffman & McNaughton in 2002 support about hippocampal-cortical networks?

<p>CA1 units represent a spatial context linked to rich set of experiences/events/episodes/landmarks (D)</p> Signup and view all the answers

What is a distinguishing feature between hippocampus and neocortex in terms of memory consolidation?

<p>Hippocampus shows fast plasticity allowing one-trial learning (A)</p> Signup and view all the answers

What is the molecular basis of plasticity and learning?

<p>Genomic tools to manipulate plasticity (B)</p> Signup and view all the answers

What are the neurophysiological basis of plasticity and learning?

<p>Habituation and sensitization (D)</p> Signup and view all the answers

What does sensitization involve in terms of early-phase functional effects?

<p>cAMP (D)</p> Signup and view all the answers

What is the role of a receptor in the neuronal signaling process?

<p>To bind to neurotransmitters (C)</p> Signup and view all the answers

What is the function of SNARE proteins in neuronal signaling?

<p>To detach synaptic vesicles from the reserve pool (C)</p> Signup and view all the answers

How does phosphorylation of SNAP-25 by PKC affect exocytosis?

<p>Inhibits interaction with syntaxin (A)</p> Signup and view all the answers

What is the main function of calmodulin in the neuronal signaling process?

<p>To form a complex with calcium ions (B)</p> Signup and view all the answers

What is the significance of synapsin I phosphorylation in neuronal signaling?

<p>Causes dissociation of synapsin I from the vesicular membrane (A)</p> Signup and view all the answers

Which molecular tool allows for spatially and temporally specific manipulation of gene expression?

<p>Optogenetics (A)</p> Signup and view all the answers

What is the primary function of LoxP / Cre in molecular biology?

<p>To disrupt original gene function (C)</p> Signup and view all the answers

Which gene manipulation tool is used to interfere with LTP and CA1 place fields?

<p>CREB-Cre (A)</p> Signup and view all the answers

What is the function of Halorhodopsins in optogenetics?

<p>Conducts chloride ions into the cytoplasm (A)</p> Signup and view all the answers

What is the key feature of viruses used as vectors in genetic engineering for optogenetics?

<p>Insertion into genomic DNA (B)</p> Signup and view all the answers

What is the primary reason for the green signal being confined to the nuclei in CA I and CA J?

<p>The green signal from ChR2-EYFP in CA I and CA J does not spread to the entire cells (D)</p> Signup and view all the answers

What is described as a single-component light-activated regulator of transmembrane ion flow?

<p>Bacteriorhodopsin (D)</p> Signup and view all the answers






<p>Dentate Gyrus, CA3, CA2, CA1, Subiculum</p> Signup and view all the answers







<p>Dentate Gyrus, CA4, CA3, CA2, CA1, Subiculum</p> Signup and view all the answers

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