18 Questions
What is the normal capacity of the liver for conjugating bilirubin per day?
3 g
What is the primary cause of haemolytic jaundice?
Increased haemoglobin breakdown
What is the result of unconjugated hyperbilirubinaemia?
Yellowish discolouration of skin and sclera
What is the approximate amount of bilirubin produced daily in an adult?
300 mg
How is hepatic jaundice diagnosed?
By measuring bilirubin levels in the blood
What is the bilirubin level above which jaundice becomes apparent?
3.0 mg/dL
What is the normal level of serum bilirubin in the blood?
1 mg/dl
What is the primary cause of unconjugated hyperbilirubinemia in neonatal physiologic jaundice?
Conjugation failure
Which type of jaundice is associated with hemolytic anemia?
Prehepatic jaundice
What is the role of the enzyme system in bilirubin metabolism?
Conversion of heme to bilirubin
What is the diagnosis of hepatic jaundice characterized by conjugation failure?
All of the above
What is the primary cause of bilirubin diglucuronide formation?
Increased water solubility of bilirubin
What is the main characteristic of Gilbert's syndrome?
Modest impairment in conjugating enzyme, glucuronyl transferase, activity
What is the typical outcome for infants affected by Type I Crigler-Najjar syndrome?
Most of them die from bilirubin-induced neurological damage before reaching 1 year of age
Which of the following genetic disorders affects 5% of the population?
Gilbert's syndrome
What is the main difference between Type I and Type II Crigler-Najjar syndrome?
Type I has a complete absence of glucuronyl transferase activity, while Type II has a partial deficiency
What is the common feature of all genetic disorders mentioned, except Gilbert's syndrome?
They are all extremely rare disorders
What is the significance of glucuronyl transferase in bilirubin metabolism?
It is involved in the conjugation of bilirubin
This quiz covers the definition, causes, and types of jaundice, including prehepatic and hemolytic jaundice. It also explores the pathophysiology of bilirubin degradation and solubility.
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