Hemolytic Anemias Quiz
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Questions and Answers

Which of the following are general evidences of hemolysis?

  • Increased red cell destruction
  • Decreased urinary Urobilinogen
  • Reticulocytosis in the bone marrow (correct)
  • Decreased unconjugated (Indirect) Bilirubin

What is the life span of a normal red cell?

  • ~120 days (correct)
  • ~60 days
  • ~90 days
  • ~150 days

Which condition may lead to splenomegaly as a result of extravascular hemolysis?

  • Hereditary spherocytosis (correct)
  • Sickle cell anemia
  • G6PD deficiency
  • Thalassemia

What is the most likely cause of hemoglobinuria and hemoglobinaemia?

<p>Intravascular hemolysis (D)</p> Signup and view all the answers

Which of the following is a genetic defect of hemoglobin?

<p>Thalassemias (D)</p> Signup and view all the answers

What is the main cause of anemia, jaundice, and splenomegaly in hemolysis?

<p>Extravascular hemolysis by macrophages of the spleen (A)</p> Signup and view all the answers

Which protein is defective in Hereditary Spherocytosis?

<p>Spectrin (B)</p> Signup and view all the answers

What is the main function of G6PD (Glucose-6-Phosphate Dehydrogenase)?

<p>Production of reduced glutathione (GSH) (D)</p> Signup and view all the answers

What was observed in black soldiers receiving antimalarial drug primaquine in relation to G6PD deficiency?

<p>Development of anemia (C)</p> Signup and view all the answers

Which enzyme protects enzymes and hemoglobin against oxidation by reducing H2O2 and free radicals?

<p>Glutathione peroxidase (B)</p> Signup and view all the answers

What symptom is NOT associated with G6PD deficiency?

<p>Fever (B)</p> Signup and view all the answers

Which disease is NOT mentioned as a cause of Acquired Hemolytic Anemia?

<p>Leukemia (B)</p> Signup and view all the answers

What is the most common red cell enzymopathy associated with hemolysis?

<p>G6PD deficiency (A)</p> Signup and view all the answers

What is the ratio of surface area to volume in spherocytes compared to normal RBCs?

<p>Lower (D)</p> Signup and view all the answers

Which X-linked trait affects males and is carried by females?

<p>G6PD deficiency (A)</p> Signup and view all the answers

What is necessary for the production of reduced glutathione (GSH) by which RBCs are protected from damage by oxidant stress?

<p>NADPH (B)</p> Signup and view all the answers

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