Podcast
Questions and Answers
What is a common extracellular barrier for both DNA and mRNA cancer vaccines?
What is a common extracellular barrier for both DNA and mRNA cancer vaccines?
- Serum nucleases (correct)
- Endocytosis
- Nuclear membrane
- Cell membrane
How do DNA and mRNA vaccines differ in terms of cellular uptake mechanisms?
How do DNA and mRNA vaccines differ in terms of cellular uptake mechanisms?
- Through caveolae and/or lipid rafts (correct)
- Temperature and dose dependent
- Endosomal pathway to reach cytosol
- Macropinocytosis
Which factor is a specific intracellular barrier for DNA vaccines but not mRNA vaccines?
Which factor is a specific intracellular barrier for DNA vaccines but not mRNA vaccines?
- Entrance to nucleus by nuclear localization signal sequences
- Cellular uptake of naked NAVs mechanisms (correct)
- Nucleases (RNase)
- Nuclear membrane
What is a shared trait between DNA and mRNA cancer vaccines in terms of endosomal pathways?
What is a shared trait between DNA and mRNA cancer vaccines in terms of endosomal pathways?
In terms of intracellular barriers, what is unique to mRNA vaccines compared to DNA vaccines?
In terms of intracellular barriers, what is unique to mRNA vaccines compared to DNA vaccines?
What is one of the strategies mentioned in the text for the success of anticancer nucleic acid vaccines (NAV)?
What is one of the strategies mentioned in the text for the success of anticancer nucleic acid vaccines (NAV)?
Which grant supported M.R.H. according to the text?
Which grant supported M.R.H. according to the text?
In the context of cancer immunotherapy, what is emphasized for personalization and efficacy?
In the context of cancer immunotherapy, what is emphasized for personalization and efficacy?
What is NOT mentioned as a strategy for next-generation cancer treatment?
What is NOT mentioned as a strategy for next-generation cancer treatment?
Which journal article discusses the past, present, and future of therapeutic cancer vaccines?
Which journal article discusses the past, present, and future of therapeutic cancer vaccines?
Which type of vaccines are discussed in the article by Rezaei T et al. (2019)?
Which type of vaccines are discussed in the article by Rezaei T et al. (2019)?
What are some challenges to the viability of NAVs as alternatives to peptide vaccines?
What are some challenges to the viability of NAVs as alternatives to peptide vaccines?
Which of the following is NOT mentioned as a characteristic that requires individual optimization for DNA and mRNA cancer vaccines?
Which of the following is NOT mentioned as a characteristic that requires individual optimization for DNA and mRNA cancer vaccines?
Who are the corresponding authors of this review?
Who are the corresponding authors of this review?
What does the publisher's disclaimer mention about the provided manuscript?
What does the publisher's disclaimer mention about the provided manuscript?
Which conflict of interest does M.R. Hamblin declare?
Which conflict of interest does M.R. Hamblin declare?
What is the main focus of the approaches discussed in the review related to anticancer NAVs?
What is the main focus of the approaches discussed in the review related to anticancer NAVs?
Where are the final destinations for encoded antigens?
Where are the final destinations for encoded antigens?
What is the role of APCs in presenting antigens to T and B cells?
What is the role of APCs in presenting antigens to T and B cells?
In what type of organs are resident B and T cells activated by APCs?
In what type of organs are resident B and T cells activated by APCs?
What process removes impurities and dsRNAs in mRNA vaccines?
What process removes impurities and dsRNAs in mRNA vaccines?
Which type of vaccine requires only crossing the cell membrane for efficacy?
Which type of vaccine requires only crossing the cell membrane for efficacy?
What contributes to the general low immunogenicity of DNA vaccines?
What contributes to the general low immunogenicity of DNA vaccines?
What type of vaccine was studied by Yuan J et al. in patients with malignant melanoma?
What type of vaccine was studied by Yuan J et al. in patients with malignant melanoma?
Which publication discussed RNAi-based therapeutic strategies for metabolic disease?
Which publication discussed RNAi-based therapeutic strategies for metabolic disease?
In the context of DNA vaccines, what was the focus of the study by Hobernik D and Bros M in 2018?
In the context of DNA vaccines, what was the focus of the study by Hobernik D and Bros M in 2018?
What was the subject of the study conducted by Kim SB et al. in 2015 related to patients with HER2-expressing breast cancer?
What was the subject of the study conducted by Kim SB et al. in 2015 related to patients with HER2-expressing breast cancer?
Which study examined the delivery of neoantigen vaccines for personalized anticancer immunotherapy?
Which study examined the delivery of neoantigen vaccines for personalized anticancer immunotherapy?
Regarding small molecules targeting the immunological tumor microenvironment, which publication discussed this topic?
Regarding small molecules targeting the immunological tumor microenvironment, which publication discussed this topic?
