29 Questions
What is a common extracellular barrier for both DNA and mRNA cancer vaccines?
Serum nucleases
How do DNA and mRNA vaccines differ in terms of cellular uptake mechanisms?
Through caveolae and/or lipid rafts
Which factor is a specific intracellular barrier for DNA vaccines but not mRNA vaccines?
Cellular uptake of naked NAVs mechanisms
What is a shared trait between DNA and mRNA cancer vaccines in terms of endosomal pathways?
Endocytosis
In terms of intracellular barriers, what is unique to mRNA vaccines compared to DNA vaccines?
Nucleases (DNase)
What is one of the strategies mentioned in the text for the success of anticancer nucleic acid vaccines (NAV)?
Small-molecule targeting of inflammatory signaling cascades
Which grant supported M.R.H. according to the text?
R01AI050875
In the context of cancer immunotherapy, what is emphasized for personalization and efficacy?
Combinatorial approaches
What is NOT mentioned as a strategy for next-generation cancer treatment?
Immunotherapy using T cells
Which journal article discusses the past, present, and future of therapeutic cancer vaccines?
Guo C et al.(2013)
Which type of vaccines are discussed in the article by Rezaei T et al. (2019)?
HIV DNA vaccines
What are some challenges to the viability of NAVs as alternatives to peptide vaccines?
Choosing the right TAs, insufficient immunogenicity, and the immunosuppressive nature of cancer
Which of the following is NOT mentioned as a characteristic that requires individual optimization for DNA and mRNA cancer vaccines?
Manufacturing process
Who are the corresponding authors of this review?
A. Mokhtarzadeh and M.R. Hamblin
What does the publisher's disclaimer mention about the provided manuscript?
It is an unedited version awaiting publication.
Which conflict of interest does M.R. Hamblin declare?
None declared
What is the main focus of the approaches discussed in the review related to anticancer NAVs?
Improving the efficiency of anticancer NAVs
Where are the final destinations for encoded antigens?
Spleen and lymph nodes
What is the role of APCs in presenting antigens to T and B cells?
Presenting epitopes
In what type of organs are resident B and T cells activated by APCs?
Spleen and lymph nodes
What process removes impurities and dsRNAs in mRNA vaccines?
Purification techniques
Which type of vaccine requires only crossing the cell membrane for efficacy?
mRNA vaccines
What contributes to the general low immunogenicity of DNA vaccines?
Poor translation of preclinical results to clinical trials
What type of vaccine was studied by Yuan J et al. in patients with malignant melanoma?
Xenogeneic tyrosinase DNA vaccine
Which publication discussed RNAi-based therapeutic strategies for metabolic disease?
Czech MP et al. (2011)
In the context of DNA vaccines, what was the focus of the study by Hobernik D and Bros M in 2018?
Clinical use of DNA vaccines
What was the subject of the study conducted by Kim SB et al. in 2015 related to patients with HER2-expressing breast cancer?
Truncated HER2 sequence vaccine
Which study examined the delivery of neoantigen vaccines for personalized anticancer immunotherapy?
Guo Y et al. (2018)
Regarding small molecules targeting the immunological tumor microenvironment, which publication discussed this topic?
Buqué A et al. (2016)
Explore the similarities and differences between barriers to DNA and mRNA cancer vaccines based on the table from Jahanafrooz et al. on page 17. Topics covered include extracellular and intracellular barriers, cellular uptake mechanisms, and more.
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