IV Infusions and Sterility

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Questions and Answers

What is a requirement for IV infusions?

They must be sterile and isotonic (correct)

They must be sterile and pyrogenic

They must be stable chemically and physically

They must be isotonic and contaminated with visible particles

What kind of stability must be maintained in IV products throughout their shelf life?

Neither physical and chemical, nor microbiological stability

Only microbiological stability

Only physical and chemical stability

Both physical and chemical, as well as microbiological stability (correct)

What is meant by 'microbiologically stable' in the context of IV products?

The product is free from pyrogenic contamination only

The product is not sterile and contains visible particulate contamination

The product is sterile and free from pyrogenic and visible particulate contamination (correct)

The product is free from visible particulate contamination only

What would happen if IV infusions were not isotonic?

Cellular destruction or creation would occur Signup and view all the answers

Why must IV products be sterile?

To prevent microbiological contamination Signup and view all the answers

What are the two common sources of heat for ovens?

Gas and electricity Signup and view all the answers

How are the ovens controlled?

Thermostatically Signup and view all the answers

Why are higher temperatures and longer periods of exposure required in dry heat?

Because dry heat is less effective Signup and view all the answers

What type of heat is less effective in killing microorganisms?

Dry heat Signup and view all the answers

What is the advantage of using moist heat?

It is more effective in killing microorganisms Signup and view all the answers

What is a key characteristic of the selected vehicle?

It should be nonirritating Signup and view all the answers

What is the primary concern when selecting a vehicle?

Its nontoxic properties Signup and view all the answers

What should be avoided when selecting a vehicle?

A vehicle that is sensitizing Signup and view all the answers

What is the main consideration when administering a vehicle?

The amount of the vehicle administered Signup and view all the answers

What should the selected vehicle not be?

Sensitizing Signup and view all the answers

What is the primary focus of topic 4 in the context of parenteral preparations?

Formulation of small and large volume preparations Signup and view all the answers

What is the primary focus of topic 8 in the context of ophthalmic preparations?

Eye anatomy and pathogenesis Signup and view all the answers

What is the primary focus of topic 5 in the context of parenteral preparations?

Additives used in parenteral preparations Signup and view all the answers

What is the primary focus of topic 6 in the context of parenteral preparations?

Quality control tests for parenteral preparations Signup and view all the answers

What is the primary focus of topic 10 in the context of ophthalmic preparations?

Different dosage forms that can be applied into the eye Signup and view all the answers

What is the primary purpose of parenteral products?

For administration via hypodermic injection Signup and view all the answers

What type of sterile product is used for instillation in the eye?

Ophthalmic Signup and view all the answers

What is an example of a topical product for exposed tissues?

Ointment Signup and view all the answers

What is the purpose of implants in parenteral therapy?

To act as a matrix for insertion into a defect site Signup and view all the answers

What is an example of a pulmonary dosage form?

Inhalation delivery system Signup and view all the answers

Study Notes

Sterile Products

IV infusions must be isotonic to ensure safe administration.
Sterile products must be stable, not only chemically and physically, but also microbiologically, maintaining sterility, freedom from pyrogenic and visible particulate contamination throughout their shelf life.

Characteristics of Vehicles

Vehicles must be nonirritating, nontoxic in the amounts administered, and not sensitizing.

Sterilization

Dry heat is less effective in killing microorganisms than moist heat, requiring higher temperatures and longer periods of exposure.
Different methods of sterilization are used in the preparation of sterile dosage forms.

Routes of Administration

Sterile dosage forms can be administered through different routes, including parenteral, ophthalmic, topical, and pulmonary routes.

Types of Sterile Products

Parenterals: packed in a manner for administration via hypodermic injection, either in the form prepared or after addition of a suitable solvent or suspending agent.
Ophthalmic: intended for instillation in the eye.
Irrigating solutions: for contact with blood vessels of wounds or abraded mucous membranes.
Topicas for exposed tissues: ointments, creams, gels, for burns, wound healing, and other skin damage.
IV systems: administration devices.
Implants: a matrix for insertion into a defect site.
Pulmonary dosage forms: inhalation delivery system.

Parenteral Therapy

Parenteral therapy is used to produce a localized effect.

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Description

This quiz assesses your knowledge of IV infusions, focusing on the importance of isotonicity, sterility, and freedom from contamination. Understand the stability requirements for IV products, including chemical, physical, and microbiological stability.