Questions and Answers
What class does Isosorbide mononitrate belong to?
What is the mechanism of Isosorbide mononitrate?
Potent coronary vasodilators; smooth muscle relaxation → ↓BP
What are the indications for using Isosorbide mononitrate?
Prophylaxis of angina; adjunct in congestive heart failure (CCF)
Which of the following are contraindications for Isosorbide mononitrate? (Select all that apply)
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What are some side effects of Isosorbide mononitrate?
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Which substances interact with Isosorbide mononitrate?
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How is Isosorbide mononitrate eliminated from the body?
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Study Notes
Isosorbide Mononitrate Overview
- Classifies as a nitrate, which helps in managing conditions related to heart disease.
Mechanism of Action
- Acts as a potent coronary vasodilator, leading to the relaxation of smooth muscle.
- Results in decreased blood pressure (BP) through widening of blood vessels.
Indications for Use
- Primarily used for the prophylaxis of angina, helping to prevent chest pain associated with coronary artery disease.
- Serves as an adjunct treatment in congestive cardiac failure (CCF).
Contraindications
- Not suitable for patients with cardiac outflow obstruction, as it can exacerbate the issue.
- Should be avoided in individuals with closed angle glaucoma due to potential intraocular pressure increases.
- Contraindicated in cases of hypersensitivity, hypotension (low blood pressure), and hypovolaemia (low blood volume).
Side Effects
- Commonly reported side effects include dizziness, potentially affecting balance.
- Postural hypotension can occur, especially when changing positions, leading to fainting.
- Headache is a frequent complaint following administration.
- Tachycardia (increased heart rate) may also be observed as an adverse reaction.
Drug Interactions
- May interact with heparin, a blood thinner, necessitating cautious co-administration.
- Co-use with sildenafil (Viagra) can lead to significant hypotension; both medications cause vasodilation.
Elimination Pathway
- Metabolized in the liver, isosorbide mononitrate is ultimately excreted through the urine, which is relevant for assessing renal function and dosage adjustments.
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Description
Test your knowledge on Isosorbide mononitrate with these flashcards. Learn about its class, mechanism, indications, and contraindications. Perfect for pharmacology students and healthcare professionals.
