Podcast
Questions and Answers
What class does Isosorbide mononitrate belong to?
What class does Isosorbide mononitrate belong to?
- Nitrates (correct)
- ACE inhibitors
- Calcium channel blockers
- Beta blockers
What is the mechanism of Isosorbide mononitrate?
What is the mechanism of Isosorbide mononitrate?
Potent coronary vasodilators; smooth muscle relaxation → ↓BP
What are the indications for using Isosorbide mononitrate?
What are the indications for using Isosorbide mononitrate?
Prophylaxis of angina; adjunct in congestive heart failure (CCF)
Which of the following are contraindications for Isosorbide mononitrate? (Select all that apply)
Which of the following are contraindications for Isosorbide mononitrate? (Select all that apply)
What are some side effects of Isosorbide mononitrate?
What are some side effects of Isosorbide mononitrate?
Which substances interact with Isosorbide mononitrate?
Which substances interact with Isosorbide mononitrate?
How is Isosorbide mononitrate eliminated from the body?
How is Isosorbide mononitrate eliminated from the body?
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Study Notes
Isosorbide Mononitrate Overview
- Classifies as a nitrate, which helps in managing conditions related to heart disease.
Mechanism of Action
- Acts as a potent coronary vasodilator, leading to the relaxation of smooth muscle.
- Results in decreased blood pressure (BP) through widening of blood vessels.
Indications for Use
- Primarily used for the prophylaxis of angina, helping to prevent chest pain associated with coronary artery disease.
- Serves as an adjunct treatment in congestive cardiac failure (CCF).
Contraindications
- Not suitable for patients with cardiac outflow obstruction, as it can exacerbate the issue.
- Should be avoided in individuals with closed angle glaucoma due to potential intraocular pressure increases.
- Contraindicated in cases of hypersensitivity, hypotension (low blood pressure), and hypovolaemia (low blood volume).
Side Effects
- Commonly reported side effects include dizziness, potentially affecting balance.
- Postural hypotension can occur, especially when changing positions, leading to fainting.
- Headache is a frequent complaint following administration.
- Tachycardia (increased heart rate) may also be observed as an adverse reaction.
Drug Interactions
- May interact with heparin, a blood thinner, necessitating cautious co-administration.
- Co-use with sildenafil (Viagra) can lead to significant hypotension; both medications cause vasodilation.
Elimination Pathway
- Metabolized in the liver, isosorbide mononitrate is ultimately excreted through the urine, which is relevant for assessing renal function and dosage adjustments.
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