Iron Overload: Chapter 4

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Questions and Answers

What is the primary mechanism to prevent iron accumulation in the body?

  • Storage of iron in organs
  • Elimination of excess iron
  • Regulation of iron absorption (correct)
  • Increased iron utilization

What is the term for excessive iron deposition in tissues?

  • Iron deficiency
  • Anemia
  • Hemochromatosis
  • Hemosiderosis (correct)

Which test is most widely used to assess iron overload and monitor its treatment?

  • Liver biopsy
  • Serum transferrin
  • Serum iron
  • Serum ferritin (correct)

What is the percentage saturation of transferrin a measure of?

<p>Iron binding capacity (B)</p> Signup and view all the answers

What is serum non-transferrin bound iron?

<p>A toxic form of iron (C)</p> Signup and view all the answers

Why is liver biopsy with staining for iron performed?

<p>To assess the degree of iron damage to organs (D)</p> Signup and view all the answers

What is the genetic defect that may contribute to African iron overload?

<p>Defect in the ferroportin gene (C)</p> Signup and view all the answers

What is the approximate amount of iron present in 500 mL of transfused blood?

<p>250 mg (C)</p> Signup and view all the answers

Why is iron absorption from food increased in β-thalassemia major?

<p>Due to release of proteins from early erythroblasts (B)</p> Signup and view all the answers

What is the result of non-transferrin bound iron in plasma?

<p>Widespread iron deposition in parenchymal tissues (D)</p> Signup and view all the answers

What is the potential consequence of moderately severe forms of thalassaemia?

<p>Increased iron levels in the liver (C)</p> Signup and view all the answers

What is the purpose of iron chelation therapy in transfusional iron overload?

<p>To prevent iron overload (A)</p> Signup and view all the answers

What is the wavelength at which the Fe(II) complex is measured spectrophotometrically?

<p>565nm (C)</p> Signup and view all the answers

What is the purpose of adding Fe(II) to serum in the UIBC determination?

<p>To bind to the unsaturated iron binding site on transferrin (D)</p> Signup and view all the answers

What is the result of the difference between the amount of Fe(II) added and the amount of Fe(II) measured in the UIBC determination?

<p>UIBC value (A)</p> Signup and view all the answers

What is the primary cause of hereditary haemochromatosis?

<p>Excessive absorption of iron from the gastrointestinal tract (A)</p> Signup and view all the answers

What is the most common genetic mutation associated with hereditary haemochromatosis?

<p>C282Y (D)</p> Signup and view all the answers

What is the organ most affected by iron overload in severe cases of hereditary haemochromatosis?

<p>Heart (B)</p> Signup and view all the answers

What is the main indication for iron chelation therapy worldwide?

<p>Thalassaemia major (C)</p> Signup and view all the answers

What is the main route of iron excretion for deferasirox?

<p>Faeces (D)</p> Signup and view all the answers

What is the recommended frequency of monitoring blood count for patients receiving deferiprone?

<p>Weekly (A)</p> Signup and view all the answers

What is the benefit of combining deferiprone with deferoxamine?

<p>Additive or synergistic effect on iron excretion (C)</p> Signup and view all the answers

What is a unique benefit of deferiprone compared to deferoxamine?

<p>More effective at removing cardiac iron (B)</p> Signup and view all the answers

What can be given to further increase iron excretion with deferoxamine?

<p>Vitamin C (C)</p> Signup and view all the answers

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