24 Questions
What is the primary mechanism to prevent iron accumulation in the body?
Regulation of iron absorption
What is the term for excessive iron deposition in tissues?
Hemosiderosis
Which test is most widely used to assess iron overload and monitor its treatment?
Serum ferritin
What is the percentage saturation of transferrin a measure of?
Iron binding capacity
What is serum non-transferrin bound iron?
A toxic form of iron
Why is liver biopsy with staining for iron performed?
To assess the degree of iron damage to organs
What is the genetic defect that may contribute to African iron overload?
Defect in the ferroportin gene
What is the approximate amount of iron present in 500 mL of transfused blood?
250 mg
Why is iron absorption from food increased in β-thalassemia major?
Due to release of proteins from early erythroblasts
What is the result of non-transferrin bound iron in plasma?
Widespread iron deposition in parenchymal tissues
What is the potential consequence of moderately severe forms of thalassaemia?
Increased iron levels in the liver
What is the purpose of iron chelation therapy in transfusional iron overload?
To prevent iron overload
What is the wavelength at which the Fe(II) complex is measured spectrophotometrically?
565nm
What is the purpose of adding Fe(II) to serum in the UIBC determination?
To bind to the unsaturated iron binding site on transferrin
What is the result of the difference between the amount of Fe(II) added and the amount of Fe(II) measured in the UIBC determination?
UIBC value
What is the primary cause of hereditary haemochromatosis?
Excessive absorption of iron from the gastrointestinal tract
What is the most common genetic mutation associated with hereditary haemochromatosis?
C282Y
What is the organ most affected by iron overload in severe cases of hereditary haemochromatosis?
Heart
What is the main indication for iron chelation therapy worldwide?
Thalassaemia major
What is the main route of iron excretion for deferasirox?
Faeces
What is the recommended frequency of monitoring blood count for patients receiving deferiprone?
Weekly
What is the benefit of combining deferiprone with deferoxamine?
Additive or synergistic effect on iron excretion
What is a unique benefit of deferiprone compared to deferoxamine?
More effective at removing cardiac iron
What can be given to further increase iron excretion with deferoxamine?
Vitamin C
Assess your knowledge of iron overload, its causes, and treatment options, including hereditary haemochromatosis and iron chelation therapy. Learn about the effects of excessive iron absorption and transfusional iron overload.
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