Podcast
Questions and Answers
What is the primary mechanism to prevent iron accumulation in the body?
What is the primary mechanism to prevent iron accumulation in the body?
- Storage of iron in organs
- Elimination of excess iron
- Regulation of iron absorption (correct)
- Increased iron utilization
What is the term for excessive iron deposition in tissues?
What is the term for excessive iron deposition in tissues?
- Iron deficiency
- Anemia
- Hemochromatosis
- Hemosiderosis (correct)
Which test is most widely used to assess iron overload and monitor its treatment?
Which test is most widely used to assess iron overload and monitor its treatment?
- Liver biopsy
- Serum transferrin
- Serum iron
- Serum ferritin (correct)
What is the percentage saturation of transferrin a measure of?
What is the percentage saturation of transferrin a measure of?
What is serum non-transferrin bound iron?
What is serum non-transferrin bound iron?
Why is liver biopsy with staining for iron performed?
Why is liver biopsy with staining for iron performed?
What is the genetic defect that may contribute to African iron overload?
What is the genetic defect that may contribute to African iron overload?
What is the approximate amount of iron present in 500 mL of transfused blood?
What is the approximate amount of iron present in 500 mL of transfused blood?
Why is iron absorption from food increased in β-thalassemia major?
Why is iron absorption from food increased in β-thalassemia major?
What is the result of non-transferrin bound iron in plasma?
What is the result of non-transferrin bound iron in plasma?
What is the potential consequence of moderately severe forms of thalassaemia?
What is the potential consequence of moderately severe forms of thalassaemia?
What is the purpose of iron chelation therapy in transfusional iron overload?
What is the purpose of iron chelation therapy in transfusional iron overload?
What is the wavelength at which the Fe(II) complex is measured spectrophotometrically?
What is the wavelength at which the Fe(II) complex is measured spectrophotometrically?
What is the purpose of adding Fe(II) to serum in the UIBC determination?
What is the purpose of adding Fe(II) to serum in the UIBC determination?
What is the result of the difference between the amount of Fe(II) added and the amount of Fe(II) measured in the UIBC determination?
What is the result of the difference between the amount of Fe(II) added and the amount of Fe(II) measured in the UIBC determination?
What is the primary cause of hereditary haemochromatosis?
What is the primary cause of hereditary haemochromatosis?
What is the most common genetic mutation associated with hereditary haemochromatosis?
What is the most common genetic mutation associated with hereditary haemochromatosis?
What is the organ most affected by iron overload in severe cases of hereditary haemochromatosis?
What is the organ most affected by iron overload in severe cases of hereditary haemochromatosis?
What is the main indication for iron chelation therapy worldwide?
What is the main indication for iron chelation therapy worldwide?
What is the main route of iron excretion for deferasirox?
What is the main route of iron excretion for deferasirox?
What is the recommended frequency of monitoring blood count for patients receiving deferiprone?
What is the recommended frequency of monitoring blood count for patients receiving deferiprone?
What is the benefit of combining deferiprone with deferoxamine?
What is the benefit of combining deferiprone with deferoxamine?
What is a unique benefit of deferiprone compared to deferoxamine?
What is a unique benefit of deferiprone compared to deferoxamine?
What can be given to further increase iron excretion with deferoxamine?
What can be given to further increase iron excretion with deferoxamine?
