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Questions and Answers
What is the effect of increased hepcidin levels in iron overload?
What is the effect of increased hepcidin levels in iron overload?
- Decreases release of iron into plasma (correct)
- No effect on release of iron into plasma
- Increases iron absorption by the body
- Increases release of iron into plasma
What is the relationship between Fe+3-Tf and hepcidin mRNA production?
What is the relationship between Fe+3-Tf and hepcidin mRNA production?
- Fe+3-Tf has no effect on hepcidin mRNA production
- Fe+3-Tf increases hepcidin mRNA production in a dose-dependent relationship (correct)
- Fe+3-Tf increases ferroportin levels in a dose-dependent relationship
- Fe+3-Tf decreases hepcidin mRNA production in a dose-dependent relationship
What is the role of low hepcidin levels in iron deficiency?
What is the role of low hepcidin levels in iron deficiency?
- Allows increased ferroportin levels and more iron to enter portal plasma (correct)
- Decreases ferroportin levels and less iron to enter portal plasma
- Increases hepcidin mRNA production
- No effect on ferroportin levels or iron absorption
Study Notes
Hepcidin and Iron Regulation
- Increased hepcidin levels have a negative effect on iron absorption and recycling, leading to decreased iron availability in iron overload.
- Hepcidin binds to ferroportin, causing its internalization and degradation, which reduces iron export from enterocytes and macrophages.
- Elevated hepcidin levels also increase Fe+3-Tf (ferric transferrin), which in turn stimulates hepcidin mRNA production, creating a feedback loop that reduces iron availability.
- Low hepcidin levels, on the other hand, contribute to iron deficiency by increasing iron absorption and recycling, as ferroportin is not internalized and degradation is reduced.
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Test your knowledge on iron metabolism and its regulation with our quiz on Hepcidin and Ferroportin. Explore the intricacies of iron release into plasma and the role of Fe+3-Tf in hepcidin mRNA production. Brush up on your understanding of intestinal iron absorption and the production of Apoferritin in bone. Take the quiz now and challenge your understanding of iron metabolism!
