Iron Absorption in the Human Body
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Questions and Answers

Which form of dietary iron is derived from hemoglobin and myoglobin of animal food sources?

  • Non-heme iron
  • Hemozinc
  • Heme iron (correct)
  • Ferrous iron
  • What is the approximate daily iron loss from menses in women of childbearing age?

  • 0.1 mg
  • 1 mg (correct)
  • 5 mg
  • 10 mg
  • Which form of dietary iron is better absorbed by the body?

  • Iron sulfate
  • Heme iron (correct)
  • Non-heme iron
  • Iron oxide
  • Where does absorption of ferrous iron primarily occur in the gastrointestinal tract?

    <p>Proximal duodenum</p> Signup and view all the answers

    What percentage of dietary iron is typically absorbed by the body?

    <p>10%</p> Signup and view all the answers

    Which condition is characterized by excessive intestinal absorption of dietary iron?

    <p>Hemochromatosis</p> Signup and view all the answers

    What is the primary cause of primary hemochromatosis?

    <p>Hepcidin deficiency</p> Signup and view all the answers

    Which organ is NOT commonly affected by iron deposition in hemochromatosis?

    <p>Brain</p> Signup and view all the answers

    What causes hemosiderosis in the reticuloendothelial system?

    <p>Multiple blood transfusions</p> Signup and view all the answers

    What is the function of ferritin in the body?

    <p>Iron carrier protein</p> Signup and view all the answers

    In iron overload conditions, what is the role of transferrin in the plasma?

    <p>Binds up to two atoms of ferric iron</p> Signup and view all the answers

    What does Total Iron Binding Capacity (TIBC) reflect in the blood?

    <p>Amount of transferrin available to bind iron</p> Signup and view all the answers

    'Bronze diabetes' is a term sometimes used to describe which condition?

    <p>Primary hemochromatosis</p> Signup and view all the answers

    Which of the following clinical features is NOT associated with iron deficiency anemia?

    <p>Jaundice</p> Signup and view all the answers

    What is the most common cause of iron deficiency anemia in the developing world?

    <p>Hookworm infestation</p> Signup and view all the answers

    Which of the following is a feature of microcytic hypochromic anemia?

    <p>Pale red blood cells</p> Signup and view all the answers

    How does ferroxidase contribute to iron transport in the body?

    <p>Oxidizes Fe2+ to Fe3+ for transport</p> Signup and view all the answers

    What is a common cause of iron deficiency anemia due to decreased iron uptake?

    <p>Malabsorption due to mucosal villi flattening</p> Signup and view all the answers

    Which of the following is NOT a cause of iron overload leading to pathological increase in iron body stores?

    <p>Genetic predisposition</p> Signup and view all the answers

    What is the role of transferrin in iron metabolism?

    <p>Carries Fe3+ in blood</p> Signup and view all the answers

    Which of the following is NOT a function of iron in the human body?

    <p>Carbohydrate metabolism</p> Signup and view all the answers

    In iron overload, the excess iron most commonly accumulates in which organ?

    <p>Liver</p> Signup and view all the answers

    Which of the following is a common clinical feature of iron deficiency anemia?

    <p>Koilonychia (spoon-shaped nails)</p> Signup and view all the answers

    Iron deficiency anemia can result from insufficient intake or absorption of iron, chronic blood loss, and:

    <p>Increased hepcidin levels</p> Signup and view all the answers

    Which condition is NOT a common cause of iron overload?

    <p>Excessive dietary intake of iron</p> Signup and view all the answers

    Which blood marker is typically decreased in iron deficiency anemia?

    <p>Serum ferritin levels</p> Signup and view all the answers

    Iron overload can lead to tissue damage through the generation of reactive oxygen species via which reaction?

    <p>&quot;Fenton reaction&quot;</p> Signup and view all the answers

    Inadequate dietary intake of which micronutrient can contribute to the development of iron deficiency anemia?

    <p>Zinc</p> Signup and view all the answers

    What is the name of the protein on the apical membrane of enterocytes that transports iron across the membrane?

    <p>Divalent Metal Cation Transporter 1 (DMT1)</p> Signup and view all the answers

    Which hormone is produced in the liver and plays a key role in controlling iron absorption by binding to and inactivating ferroportin?

    <p>Hepcidin</p> Signup and view all the answers

    In a classical feedback system, what stimulates hepcidin production which leads to decreased iron absorption?

    <p>Increased plasma iron</p> Signup and view all the answers

    Which protein is responsible for oxidizing Fe2+ to Fe3+ for storage of normal amounts of Fe3+ in tissues under normal conditions?

    <p>Ferritin</p> Signup and view all the answers

    What is generated from ferritin denaturation under conditions of iron overload?

    <p>Hemosiderin</p> Signup and view all the answers

    Which type of gastric acidity decrease can lead to lower iron absorption?

    <p>Hypochlorhydria</p> Signup and view all the answers

    What is the name of the transporter that allows iron to be transported through the basolateral membrane and into circulation?

    <p>Ferroportin</p> Signup and view all the answers

    Which nutrient is regulated by Hepcidin in a manner where it controls the delivery of this nutrient from intestinal cells to blood?

    <p>Iron</p> Signup and view all the answers

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