Iron Absorption and Deficiency Anemia
8 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following are hypotheses that explain the control of intestinal iron absorption? (Select all that apply)

  • Mucosal Block Hypothesis (correct)
  • Protein Transport Hypothesis
  • Active Transport Hypothesis (correct)
  • Iron-Chelate Hypothesis (correct)
  • What is iron absorption regulated by according to the mucosal block hypothesis?

    Apoferritin

    The form in which iron is transferred to the liver for storage is known as ______.

    transferrin

    The active transport hypothesis suggests that iron absorption is not affected by anaerobic conditions.

    <p>True</p> Signup and view all the answers

    Match the following causes of anemia with their descriptions:

    <p>Excessive loss of blood = Causes include bleeding ulcers and menstrual flow. Blood destruction = Causes include hemolytic agents and defective hemoglobin. Decreased blood formation = Causes include deficiencies in key materials and infections.</p> Signup and view all the answers

    Iron chelate hypothesis does not require metabolic energy for iron movement.

    <p>True</p> Signup and view all the answers

    What two requirements must an iron compound meet for replacement or supplemental therapy?

    <p>It must be biologically available and non-irritating.</p> Signup and view all the answers

    Which iron compound is usually compared as a standard for other iron salts?

    <p>Ferrous sulfate</p> Signup and view all the answers

    Study Notes

    Iron Absorption

    • Three hypotheses explain regulation of Iron absorption:
      • Mucosal Block Hypothesis: Iron absorption is regulated by the cell's apoferritin levels. Ferrous iron is absorbed into the mucosal cell, oxidized, and forms ferritin. Ferritin is then released into the blood and transported to the liver for storage and the bone marrow for heme synthesis.
      • Active Transport Hypothesis: Iron absorption is regulated by an active transport system. This system requires ATP to move iron across the serosal membrane.
      • Iron Chelate Hypothesis: Iron absorption is regulated by endogenous or exogenous ligands (chelating agents). These ligands bind to iron and form low molecular weight complexes that passively diffuse across the mucosal membrane. Iron is then either stored as ferritin or transferred to other ligands.

    Iron Deficiency Anemia

    • Iron deficiency anemia is a condition where circulating red blood cells are deficient in number or total hemoglobin content.
    • This deficiency results in lower oxygen-carrying capacity of blood.
    • Iron deficiency can be caused by:
      • Excessive blood loss: bleeding ulcers, hemorrhaging, heavy menstrual flow.
      • Blood destruction: hemolytic agents like drugs, infections, toxins, or defective hemoglobin like sickle cell anemia and thalassemia.
      • Decreased blood formation: deficiencies in cobalamin, folic acid, pyridoxine, and iron, infections, renal insufficiency, malignancy, or marrow failure.

    Iron Supplements

    • Iron compounds used for supplemental therapy need to be:
      • Biologically available
      • Non-irritating
    • Water-soluble ferrous sulfate is the standard reference for iron salts.
    • Sustained release iron formulations are used to minimize the irritant properties of iron.
    • Parenteral iron preparations are indicated for cases where oral iron is ineffective or contraindicated.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Description

    This quiz explores the mechanisms of iron absorption and the condition of iron deficiency anemia. It covers three hypotheses explaining the regulation of iron absorption and discusses the implications of iron deficiency on red blood cell counts and hemoglobin levels. Test your knowledge on this essential topic in human nutrition.

    More Like This

    Iron Deficiency Anemia and Absorption L1
    29 questions
    Iron Deficiency Anemia and Causes
    39 questions
    Iron Deficiency Anemia Overview
    18 questions

    Iron Deficiency Anemia Overview

    LikedBaritoneSaxophone avatar
    LikedBaritoneSaxophone
    Use Quizgecko on...
    Browser
    Browser