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Ionisation of Weak Acids and Bases Quiz
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Ionisation of Weak Acids and Bases Quiz

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Questions and Answers

Which of the following statements best describes the relationship between ionization and passive diffusion of weak acid drugs?

  • Weak acid drugs are more permeable to cell membranes in their unionized form. (correct)
  • Ionization status does not affect the passive diffusion of weak acid drugs.
  • Weak acid drugs can only passively diffuse through cell membranes in their ionized form.
  • Weak acid drugs are more permeable to cell membranes in their ionized form.

    • A weak acid drug has a pKa of 4.5. In an environment with a pH of 3.0, what is the primary ionization state of this drug?

  • Mostly unionized
  • Equally ionized and unionized
  • Mostly ionized (correct)
  • The ionization state cannot be determined from the given information.

    • How does the ionization state of a drug molecule affect its ability to passively diffuse across a cell membrane?

  • Unionized molecules have higher membrane permeability than ionized molecules. (correct)
  • Ionized molecules have higher membrane permeability than unionized molecules.
  • Ionized molecules can only passively diffuse through specialized ion channels.
  • Ionization state does not affect passive diffusion across cell membranes.

    • A drug has a pKa of 8.2. In an environment with a pH of 7.4, what is the primary ionization state of this drug?

    <p>Mostly unionized</p> Signup and view all the answers

    How does the lipophilicity of a drug molecule affect its ability to passively diffuse across a cell membrane?

    <p>Lipophilic molecules can easily dissolve in the lipid bilayer and pass through, while hydrophilic molecules cannot.</p> Signup and view all the answers

    A drug has a pKa of 7.0. In an environment with a pH of 6.0, what is the primary ionization state of this drug?

    <p>Mostly ionized</p> Signup and view all the answers

    In the stomach (pH 1.5), aspirin, a weak acid with a pKa of 3, will most likely exist in which ionization state?

    <p>Unionized</p> Signup and view all the answers

    Which form of aspirin, a weak acid, is more likely to diffuse through biological membranes in the stomach?

    <p>The unionized form</p> Signup and view all the answers

    Which transport mechanism is primarily responsible for the absorption of drugs in the small intestine, regardless of their ionization state?

    <p>Passive diffusion</p> Signup and view all the answers

    What is the primary consequence of a drug molecule being in its ionized state when attempting to cross a biological membrane?

    <p>The drug will be retained within its current environment</p> Signup and view all the answers

    If a drug transporter or carrier is saturated, what is the most likely clinical outcome?

    <p>The drug's absorption and distribution will be delayed or reduced</p> Signup and view all the answers

    Which type of transport mechanism is responsible for moving drug molecules against their concentration gradient while utilizing cellular energy (ATP)?

    <p>Primary active transport</p> Signup and view all the answers

    Which factor affects the absorption of drugs such as onset, duration, and intensity of action?

    <p>Passive transport</p> Signup and view all the answers

    In drug transport across biological membranes, which type does not require energy and moves along a concentration gradient?

    <p>Simple diffusion</p> Signup and view all the answers

    Which type of transport involves movement from high to low concentration without the use of cellular energy?

    <p>Simple diffusion</p> Signup and view all the answers

    Among the different subtypes of passive transport, which one involves the direct movement of a drug through a semi-permeable membrane until equilibrium is reached?

    <p>Simple diffusion</p> Signup and view all the answers

    For drugs undergoing passive diffusion, which transport mechanism involves movement along a concentration gradient without using cellular energy?

    <p>Simple diffusion</p> Signup and view all the answers

    Which transport type is most frequently utilized by drugs for passive transport due to its direct movement through a semi-permeable membrane?

    <p>Simple diffusion</p> Signup and view all the answers

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