Introduction to Viruses

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Questions and Answers

Which of the following is a protein coat that surrounds the genetic material of a virus?

  • Spike
  • Capsid (correct)
  • Envelope
  • Capsomere

What distinguishes an enveloped virus from a non-enveloped virus?

  • Presence of a protein capsid
  • Ability to infect bacteria
  • Presence of a lipid membrane (correct)
  • Type of genetic material

What is the function of the enzyme reverse transcriptase, commonly found in retroviruses?

  • Degrading viral RNA
  • Synthesizing proteins from mRNA
  • Synthesizing DNA from an RNA template (correct)
  • Replicating DNA from a DNA template

In the lytic cycle, what is the immediate result of a virus infecting a host cell?

<p>Replication of the viral genome and production of viral proteins (B)</p> Signup and view all the answers

What is a prophage?

<p>The genetic material of a bacteriophage, incorporated into the host bacterium's DNA (B)</p> Signup and view all the answers

Which of the following best describes a latent viral infection?

<p>An infection that remains dormant in the host cell for an extended period (C)</p> Signup and view all the answers

How do prions differ from viruses?

<p>Prions are infectious proteins, while viruses contain nucleic acid enclosed in a protein coat (B)</p> Signup and view all the answers

What is a viroid?

<p>A small, circular RNA molecule that infects plants (C)</p> Signup and view all the answers

In contrast to the lytic cycle, what is the key characteristic of the lysogenic cycle?

<p>Integration of the viral genome into the host genome without immediate host cell destruction (D)</p> Signup and view all the answers

What is the role of 'spikes' found on the surface of some viruses?

<p>To facilitate attachment and entry into host cells (A)</p> Signup and view all the answers

Which description accurately defines a 'bacteriophage'?

<p>A virus that infects bacteria (C)</p> Signup and view all the answers

What is the primary reason persistent viral infections can be challenging to treat?

<p>The virus can exist in a latent or chronic state, making it difficult to eradicate (C)</p> Signup and view all the answers

Which feature is unique to retroviruses that sets them apart from other virus types?

<p>They integrate their DNA into the host cell's genome using reverse transcriptase (A)</p> Signup and view all the answers

If a virus lacks an envelope, what might be a consequence for its method of entry into a host cell?

<p>It may require specific protein receptors on the cell surface for entry (D)</p> Signup and view all the answers

What implication does the presence of a prophage have for a bacterium?

<p>The bacterium has gained new genetic material that may alter its characteristics (B)</p> Signup and view all the answers

Which of the following is NOT a component of a virus?

<p>Ribosomes (B)</p> Signup and view all the answers

Consider a newly discovered virus that integrates its RNA genome into the host cell's DNA but does not possess reverse transcriptase activity. Which of the following is the MOST likely explanation for this observation?

<p>The virus is utilizing a pre-existing reverse transcriptase enzyme within the host cell. (D)</p> Signup and view all the answers

A researcher is studying a novel bacteriophage and observes that after infecting E. coli, the bacterial cells exhibit increased resistance to specific antibiotics. What is the MOST plausible mechanism underlying this phenomenon?

<p>The bacteriophage carries genes encoding antibiotic resistance that are integrated into the bacterial chromosome via lysogeny. (A)</p> Signup and view all the answers

A scientist discovers a new infectious agent that consists only of protein and causes neurodegenerative disease. Based on this information, which of the following is the MOST likely identity of the infectious agent?

<p>A prion (D)</p> Signup and view all the answers

Imagine a scenario where a scientist is attempting to culture a newly discovered virus in a laboratory setting. Initial attempts to infect various cell lines are unsuccessful. However, when the scientist introduces a specific bacterial species to the cell culture, the virus successfully infects the cells. This observation suggests that the bacterial species is MOST likely providing which crucial factor for viral infection?

<p>A structural component necessary for viral entry into the host cells. (B)</p> Signup and view all the answers

Flashcards

What is a virus?

A non-cellular infectious agent that replicates only inside the living cells of an organism.

Capsid

The protein shell of a virus, enclosing its genetic material.

Spike (virus)

Glycoprotein projections on the surface of a virus that aid in attachment to host cells.

Virus envelope

A membrane-like structure surrounding the capsid of some viruses, derived from the host cell membrane.

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Non-enveloped virus

Viruses that lack a lipid envelope surrounding the capsid.

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Capsomere

A subunit of the capsid, an outer covering of protein that protects the genetic material of a virus.

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Persistent virus

A type of viral infection where the virus remains in the host for long periods, sometimes for life.

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Latent virus

A type of persistent viral infection where the virus remains dormant in the host cell and can reactivate later.

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Retroviridae

A family of viruses that use reverse transcriptase to convert RNA into DNA.

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Reverse transcriptase

An enzyme used by retroviruses to synthesize DNA from an RNA template.

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Lytic Cycle

The viral replication cycle that involves destruction of the infected cell and its membrane.

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Lysogenic Cycle

Viral replication cycle where the viral DNA is incorporated into the host DNA without destroying the cell.

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Viroid

An infectious entity consisting only of RNA, causing diseases in plants.

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Prion

Infectious proteins that cause neurodegenerative diseases.

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Prophage

A bacteriophage genome that has been inserted into a specific site on the bacterial chromosome.

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Bacteriophage

A virus that infects and replicates within bacteria and archaea.

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Study Notes

  • Microbiology is the study of microorganisms, including viruses.
  • A virus is a non-cellular infectious agent that can only replicate inside a living host cell.
  • Viruses possess a capsid, which is a protein shell that encloses their genetic material (DNA or RNA).
  • Some viruses have a lipid envelope surrounding the capsid, while others lack an envelope and are considered non-enveloped viruses.
  • The envelope is derived from the host cell membrane during viral release.
  • Capsomeres are the protein subunits that make up the capsid.
  • A persistent virus establishes a long-term infection, which can be chronic or latent.
  • A latent virus remains dormant within the host cell without causing immediate symptoms, but can reactivate later.
  • Retroviridae is a family of viruses that includes HIV; they use reverse transcriptase to convert their RNA genome into DNA for integration into the host cell's genome.
  • Reverse transcriptase is an enzyme that synthesizes DNA from an RNA template.

Viral Replication Cycles

  • The lytic cycle is a viral replication pathway that results in the destruction of the host cell through lysis.
  • The lysogenic cycle is a viral replication pathway where the viral genome integrates into the host cell's chromosome, without causing immediate cell lysis.
  • A prophage is a bacteriophage DNA that has integrated into the bacterial host's chromosome during the lysogenic cycle.
  • Bacteriophages are viruses that infect bacteria.

Other infectious agents

  • Viroids are small, circular RNA molecules that infect plants.
  • Prions are infectious proteins that cause neurodegenerative diseases.

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