Introduction to Super Scientists

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Questions and Answers

What is a primary goal of transgenic research?

  • To understand the role of genetics in mouse diseases.
  • To study the function of healthy genes in all organisms.
  • To breed mice with human-like characteristics for testing.
  • To develop better treatments for human diseases. (correct)

Which of the following diseases are scientists trying to study using laboratory mice?

  • Cancer and Alzheimer's disease (correct)
  • Ebola and malaria
  • Diabetes and arthritis
  • Influenza and chickenpox

Where is the genetic material modified in laboratory mice for transgenic research?

  • In the cytoplasm
  • In the chromosomes (correct)
  • In the mitochondria
  • In the ribosomes

Why do scientists create 'unhealthy' genes in laboratory mice?

<p>To understand how 'good' genes function. (B)</p> Signup and view all the answers

What role do laboratory mice play in discovering treatments for human diseases?

<p>They serve as models to study the development of human-like diseases. (B)</p> Signup and view all the answers

What can be achieved by transferring genes from one organism to laboratory mice?

<p>Producing mice that develop human-like diseases (D)</p> Signup and view all the answers

How do scientists use laboratory mice to explore genetics and heredity related to human disease?

<p>By transferring healthy or unhealthy genes to mice (A)</p> Signup and view all the answers

According to the content, what is a key question scientists are trying to answer with the help of laboratory mice?

<p>Why does one member of a family get a disease and another does not? (C)</p> Signup and view all the answers

What is the primary focus of Dr. Carol Macleod's research as a geneticist?

<p>Investigating how genes relate to cancer. (C)</p> Signup and view all the answers

What does genetics, as a branch of biology, primarily deal with?

<p>The study of heredity and variations in living things. (D)</p> Signup and view all the answers

What is the primary function of chromosomes within a cell?

<p>To store and transmit genetic information (C)</p> Signup and view all the answers

What is the role of DNA?

<p>It provides the code for proteins needed by cells. (C)</p> Signup and view all the answers

What are the two primary sources from which an individual inherits chromosomes?

<p>Mother and father (A)</p> Signup and view all the answers

What is the implication of a missing, incomplete, damaged, or duplicated gene?

<p>It can lead to diseases or illnesses. (D)</p> Signup and view all the answers

What is deoxyribonucleic acid, most commonly known as DNA?

<p>A chemical containing the 'secret code' information for living things (A)</p> Signup and view all the answers

How many genes are contained within each of your cells, according to the content provided?

<p>Approximately 100,000 genes. (C)</p> Signup and view all the answers

How can external factors impact disease susceptibility?

<p>They can increase the risk of illness when combined with genetic factors. (D)</p> Signup and view all the answers

What is the role of proteins as described in the text?

<p>To help keep the body healthy and sustain life. (B)</p> Signup and view all the answers

Why are laboratory mice frequently used in genetic studies?

<p>Because they allow scientists to learn gene function. (B)</p> Signup and view all the answers

The content uses the analogy that DNA structure is similar to what?

<p>A twisted ladder. (A)</p> Signup and view all the answers

What does 'inherited' mean in the context of genetics discussed in the text?

<p>Passed down from one family member to the next. (C)</p> Signup and view all the answers

What is the main goal of the Human Genome Project?

<p>To identify and 'map' of all the human genes on chromosomes. (D)</p> Signup and view all the answers

According to the passage, what is one way better treatments are being devised to prevent or cure illness?

<p>Using gene replacement. (C)</p> Signup and view all the answers

Approximately what percentage of animals used in research are rodents?

<p>95 percent (B)</p> Signup and view all the answers

What is one primary goal of genetic research?

<p>To reduce suffering related to inherited disorders (C)</p> Signup and view all the answers

What is a significant role of laboratory mice in genetic research according to the provided text?

<p>To act as a model for understanding complex human traits (D)</p> Signup and view all the answers

What concern is raised about the potential of genetic research?

<p>That it might be going 'too far' ethically (A)</p> Signup and view all the answers

What is the primary reason mice are considered good models for transgenic research?

<p>Mice are mammals with organs that function similarly to humans, and 80% similar DNA. (A)</p> Signup and view all the answers

What action is planned for the adult transgenic mice within the context of the research?

<p>They will be bred with non-transgenic mice of the same breed (D)</p> Signup and view all the answers

Approximately how many inherited disorders may be identified using genetic science methods?

<p>Around 4,000 (C)</p> Signup and view all the answers

What is a key benefit of mice having a short gestation period in transgenic research?

<p>It allows researchers to quickly observe multiple generations of mice in a shorter amount of time. (B)</p> Signup and view all the answers

Why is it important to have a 'control' group in transgenic mouse research?

<p>To provide a comparison group to see if any effects are directly related to the added transgene. (C)</p> Signup and view all the answers

What is explicitly NOT considered a purpose of the genetics research mentioned in the text?

<p>To make one group better than another (C)</p> Signup and view all the answers

What is a role of a Genetics Laboratory Technician according to the text?

<p>To assist in the genetic laboratory (D)</p> Signup and view all the answers

How are scientists able to determine if a specific gene is contributing to a disease?

<p>By studying transgenic mice family trees and their genetic testing. (D)</p> Signup and view all the answers

Why is mouse size considered beneficial for transgenic research?

<p>Small size means they are cheap to keep in large numbers, and they require less lab space. (C)</p> Signup and view all the answers

What type of professional directly uses information from genetic research to treat patients?

<p>A Clinical Geneticist (A)</p> Signup and view all the answers

In the context of transgenic research, what does "transgene" typically refer to?

<p>A gene that has been introduced into the genome of an organism e.g a mouse. (B)</p> Signup and view all the answers

When do female mice typically begin to reproduce, according to the text?

<p>Four weeks after birth. (B)</p> Signup and view all the answers

Why do scientists use a hypothesis, in transgenic research?

<p>To have a hunch or idea they can test, similar to a detective trying to solve a case. (A)</p> Signup and view all the answers

What is the primary function of DNA?

<p>To provide the genetic code and produce proteins for the body. (D)</p> Signup and view all the answers

Which term describes a segment of DNA that controls a hereditary characteristic?

<p>Gene (D)</p> Signup and view all the answers

What is the purpose of 'Gene Knockout' Therapy?

<p>To study the effects of a disease model by replacing healthy genes with defective ones. (C)</p> Signup and view all the answers

Within a cell, which structure acts as the control center?

<p>Nucleus (D)</p> Signup and view all the answers

What is considered a 'trait' in the context of genetics?

<p>A characteristic passed on from parents to offspring. (B)</p> Signup and view all the answers

What is a 'transgene'?

<p>A gene that has been transferred to another organism. (D)</p> Signup and view all the answers

What is the Human Genome Project's main objective?

<p>To understand the function of all human genes and their contribution to disease. (A)</p> Signup and view all the answers

What is a 'hypothesis' in the context of scientific inquiry?

<p>A tentative explanation for an observation that can be tested. (D)</p> Signup and view all the answers

Flashcards

Transgenic Research

The study of how genes affect a person's health and how genes can be used to develop new treatments for diseases.

Laboratory Mice in Transgenic Research

Laboratory animals used in research to study diseases by modifying their genes to mimic human conditions.

Chromosomes

Specialized structures within a cell that contain the genetic material and determine the traits of an organism.

Gene Transfer

The process of transferring genes from one organism to another, including laboratory mice, to study genetic effects.

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Genetic Material Modification

A change in the genetic material within chromosomes, which can lead to changes in traits, including susceptibility to disease.

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Breeding Mice with Human-Like Conditions

The process of creating mice with human-like conditions, such as cancer or Alzheimer's disease, through gene modification.

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Benefits of Transgenic Research

The potential benefits of using laboratory mice in genetic research to develop treatments and cures for diseases.

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Genetics and Heredity

The study of heredity and how traits are passed down from parents to offspring.

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Genetics

The study of how traits are passed from parents to offspring.

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Genes

The material in our body that contains all our inherited traits.

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Gene

A small portion of DNA that codes for a specific protein.

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DNA

A twisted ladder-like structure that contains all the genetic information in a cell.

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Gene mutation

A change in the sequence of DNA that can lead to disease.

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Heredity

The process of passing traits from parents to offspring.

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Variation

The differences in traits among individuals.

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Genetics

The branch of biology that deals with the heredity and differences in various living things.

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DNA (Deoxyribonucleic Acid)

The blueprint for our bodies. Contains instructions for traits, growth, and development.

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Cells

The building blocks of our cells.

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The Human Genome Project

A project aiming to map and understand the entire human genome.

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Genetic Studies using Mice

A technique using specially bred mice to study gene function and disease.

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Gene Therapy/Replacement

A medical approach using genes to treat or prevent diseases.

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Mice as Model Organisms

Mice share about 80% of their DNA with humans, making them suitable models for understanding human biology and disease.

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Mice Life Cycles

Mice have a relatively short lifespan and gestation period, allowing scientists to study multiple generations over a shorter timescale.

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Control Group in Transgenic Research

Scientists use control groups of non-transgenic mice to compare against transgenic mice, helping to identify and isolate the effects of the modified gene.

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Identifying Disease Genes

Scientists use family studies and genetic testing to identify genes potentially linked to specific diseases.

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Hypothesis in Research

A hypothesis is a testable prediction or assumption made by scientists before conducting research.

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Testing a Hypothesis with Transgenic Mice

Scientists test their hypothesis by creating transgenic mice and comparing them to control mice to determine if the modified gene causes the expected changes.

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Transgenic Research Findings

The results of transgenic research can provide evidence for a link between a specific gene and a particular disease.

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Transgenic mouse

A laboratory animal, often a mouse, whose genes have been modified to study diseases or medical treatments.

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Benefits of Genetic Research

The potential to use genetic research to develop new treatments and cures for diseases.

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Ethical considerations in genetic research

The study of genetics raises ethical questions about how far science should go in manipulating genes.

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Clinical Geneticist

A scientist who studies the structure, function, and inheritance of genes, and applies knowledge to understand and treat diseases.

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Nucleus

The control center of the cell, directing all cellular activities. It contains DNA, which holds the genetic instructions.

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Transgene

A gene introduced into an organism from a different species during transgenic research. It can be healthy or unhealthy.

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Gene 'Knockout' Therapy

An area of science that involves replacing a healthy gene with a defective gene to study its effects on disease. It helps scientists understand the role of genes in health and disease.

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Hypothesis

A tentative explanation or prediction that can be tested through further investigation.

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Embryo

A mammal in the early stages of development before birth.

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Study Notes

Introduction to Super Scientists

  • This booklet explores how mice are vital to scientific research, particularly in understanding disease.
  • Mice share genetic similarities with humans – approximately 80% similar DNA structure.
  • Mice are frequently used in research because of their close biological similarities and a relatively short lifespan.

Transgenic Research

  • Scientists use transgenic research to transfer "healthy" and "unhealthy" genes from one organism to another.
  • This is done in mice to study human-like diseases and conditions.
  • Genes are added to the DNA of mice in order to study diseases such as human cancers, Alzheimer's, or asthma.
  • The scientists use "knock-out" therapy which involves the removal of a healthy gene. This is used to study these diseases.

Mice as Models

  • Mice are valuable research models due to their short gestation period and quick reproduction
  • Mice live about 2 years and 4 weeks, which allows for observing multiple generations.
  • The close biological proximity to humans makes the mouse an ideal subject.
  • Mice are easy to care for and to keep in a lab setting.

Genetics

  • Genetics is the study of heredity and differences in living organisms.
  • Genes are units of DNA (deoxyribonucleic acid), organized in precise order and they control certain traits.
  • Humans have approximately 100,000 genes.
  • Humans contain 46 chromosomes (23 pairs).
  • DNA is the chemical code for nearly all inherited traits.
  • Cells are the body's building blocks, composed of chromosomes which hold DNA.

Future of Genetic Research

  • Scientists believe that genetic research will have significant impact on treating diseases.
  • Ethical questions about genetic research will continue to arise as advances are made.
  • The goal of genetic research is to reduce suffering, not to enhance traits.

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