16 Questions
What is the main focus of immunoassays?
To study the presence or concentration of molecules (antigen/antibody) in a solution using antibodies/antigens.
What is the difference between immunoassays and serology?
Immunoassays focus on the presence or concentration of molecules in a solution, while serology studies the presence of infection and other diseases by detecting antibodies/antigens in blood/plasma/serum.
What are some examples of immunoassays?
Agglutination, Enzyme immunoassays (ELISA), Lateral flow Immunoassay, Fluorescence immunoassays (Flow Cytometry).
How are antibodies used to detect antigens or vice versa?
Antibodies are used to detect antigens, and antigens are used to detect antibodies, based on the specificity of the interaction between antigen and antibody.
How is antiserum produced for research and diagnostic purposes?
Antiserum is obtained by injecting a lab animal with a specific antigen, leading to the production of antibodies against the antigen.
What is the potential application of Serology tests for SARS-CoV-2?
They can help detect if a person has been exposed to Covid-19 and potentially developed an immune response to the virus.
What percentage of COVID-19 cases are transmitted by contact with presymptomatic individuals?
47%
What percentage of COVID-19 cases are transmitted from contact with asymptomatic individuals?
6%
What can serology tests detect in mild/asymptomatic cases of COVID-19?
Serology tests can detect mild/asymptomatic cases.
What are the two distinct ways serologic testing may be used in the clinical laboratory?
Direct serologic testing and indirect serologic testing.
What does indirect serologic testing detect in the patient's serum?
Indirect serologic testing detects antibodies being made against a specific antigen in the patient's serum.
Based on the principle mentioned, what can antigen-antibody interactions result in?
Antigen-antibody interactions can result in agglutination of particulate antigens, precipitation of soluble antigens, neutralization of toxins and viruses, activation of complement, and labeling of antibodies.
In the context of the text, what is the principle behind serologic testing?
The principle behind serologic testing is to use known antibodies to identify unknown antigens or to detect antibodies being made against a specific antigen in the patient's serum.
What are some examples of what immunoassays/serology can detect and measure?
Immunoassays/serology can detect and measure the level of hormones, drugs, abnormal antibodies, HLA typing, white blood cell types, and blood group antigens.
What are the three main purposes of serologic testing in the clinical laboratory?
The three main purposes of serologic testing in the clinical laboratory are to identify unknown antigens, to detect antibodies being made against a specific antigen in the patient's serum, and to detect and measure the level of various substances.
What can serology tests for SARS-CoV-2 detect?
Serology tests for SARS-CoV-2 can detect if people have an immune response to the coronavirus.
Test your knowledge of serology and immunoassays, which are used to detect antibodies and antigens in blood, plasma, and serum. This quiz covers the principles and examples of immunoassays, including techniques like agglutination and enzyme immunoassays.
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