Introduction to Serology and Immunoassays Quiz
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Questions and Answers

What is the main focus of immunoassays?

To study the presence or concentration of molecules (antigen/antibody) in a solution using antibodies/antigens.

What is the difference between immunoassays and serology?

Immunoassays focus on the presence or concentration of molecules in a solution, while serology studies the presence of infection and other diseases by detecting antibodies/antigens in blood/plasma/serum.

What are some examples of immunoassays?

Agglutination, Enzyme immunoassays (ELISA), Lateral flow Immunoassay, Fluorescence immunoassays (Flow Cytometry).

How are antibodies used to detect antigens or vice versa?

<p>Antibodies are used to detect antigens, and antigens are used to detect antibodies, based on the specificity of the interaction between antigen and antibody.</p> Signup and view all the answers

How is antiserum produced for research and diagnostic purposes?

<p>Antiserum is obtained by injecting a lab animal with a specific antigen, leading to the production of antibodies against the antigen.</p> Signup and view all the answers

What is the potential application of Serology tests for SARS-CoV-2?

<p>They can help detect if a person has been exposed to Covid-19 and potentially developed an immune response to the virus.</p> Signup and view all the answers

What percentage of COVID-19 cases are transmitted by contact with presymptomatic individuals?

<p>47%</p> Signup and view all the answers

What percentage of COVID-19 cases are transmitted from contact with asymptomatic individuals?

<p>6%</p> Signup and view all the answers

What can serology tests detect in mild/asymptomatic cases of COVID-19?

<p>Serology tests can detect mild/asymptomatic cases.</p> Signup and view all the answers

What are the two distinct ways serologic testing may be used in the clinical laboratory?

<p>Direct serologic testing and indirect serologic testing.</p> Signup and view all the answers

What does indirect serologic testing detect in the patient's serum?

<p>Indirect serologic testing detects antibodies being made against a specific antigen in the patient's serum.</p> Signup and view all the answers

Based on the principle mentioned, what can antigen-antibody interactions result in?

<p>Antigen-antibody interactions can result in agglutination of particulate antigens, precipitation of soluble antigens, neutralization of toxins and viruses, activation of complement, and labeling of antibodies.</p> Signup and view all the answers

In the context of the text, what is the principle behind serologic testing?

<p>The principle behind serologic testing is to use known antibodies to identify unknown antigens or to detect antibodies being made against a specific antigen in the patient's serum.</p> Signup and view all the answers

What are some examples of what immunoassays/serology can detect and measure?

<p>Immunoassays/serology can detect and measure the level of hormones, drugs, abnormal antibodies, HLA typing, white blood cell types, and blood group antigens.</p> Signup and view all the answers

What are the three main purposes of serologic testing in the clinical laboratory?

<p>The three main purposes of serologic testing in the clinical laboratory are to identify unknown antigens, to detect antibodies being made against a specific antigen in the patient's serum, and to detect and measure the level of various substances.</p> Signup and view all the answers

What can serology tests for SARS-CoV-2 detect?

<p>Serology tests for SARS-CoV-2 can detect if people have an immune response to the coronavirus.</p> Signup and view all the answers

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