Introduction to Poisons Quiz

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Questions and Answers

Which of the following is an example of acute poisoning?

  • Sleeping pills taken in excess (correct)
  • Lead exposure over many years
  • Chronic alcohol consumption
  • Mercury exposure from fish

Chronic poisoning results from exposure to harmful substances for a short span of time.

False (B)

What are two routes of systemic absorption for harmful substances?

Oral and intravenous

The term ______ refers to the quantity of a substance that can cause death in 50% of a test population.

<p>Median Lethal Dose (LD50)</p> Signup and view all the answers

Match the types of toxic effects with their description:

<p>Pharmacological = Exaggeration of effects Genotoxic = Damage to DNA Pathological = Injury to tissue Chronic = Gradual deterioration over time</p> Signup and view all the answers

Which evidence of poisoning is exhibited by the patient?

<p>Symptomatic (C)</p> Signup and view all the answers

Heavy metals are an example of substances that can cause chronic toxicity.

<p>True (A)</p> Signup and view all the answers

Name one route through which toxic substances can be absorbed through the skin.

<p>Direct cutaneous absorption</p> Signup and view all the answers

Which type of poisoning is characterized by the unintentional ingestion of a substance?

<p>Accidental (A)</p> Signup and view all the answers

Homicidal poisoning is when the poison is taken voluntarily by the victim.

<p>False (B)</p> Signup and view all the answers

What is one factor affecting the absorption of poison?

<p>Solubility of Poison</p> Signup and view all the answers

Which of the following is an example of cumulative poisoning?

<p>Metal poisons (C)</p> Signup and view all the answers

The symptoms of poisoning can include _____ discoloration of the skin.

<p>yellow</p> Signup and view all the answers

Cumulative poisons are non-toxic even in large doses.

<p>False (B)</p> Signup and view all the answers

Which of the following is NOT a type of evidence in poisoning cases?

<p>Official testimony (C)</p> Signup and view all the answers

Match the following symptoms with their associated substances:

<p>Cherry Red Blood = CO, CN-‾ Bluish Gray Skin = Boiled Lobster Appearance Sweet penetrating odor = Acetone, Chloroform Yellow Stool = Fe, Charcoal, Bi, Pb, MgO, AgNO3</p> Signup and view all the answers

What is the term for the need of more of the drug to produce the same effect?

<p>Tolerance</p> Signup and view all the answers

Which of these tests is used to detect arsenic poisoning?

<p>Marsh test (D)</p> Signup and view all the answers

Corrosives cause local destruction of body parts but are not ______ if diluted.

<p>poisonous</p> Signup and view all the answers

Match each type of poison with its correct description:

<p>Corrosives = Can cause local destruction but are less harmful when diluted True Poisons = Highly toxic substances with no medicinal value Cumulative Poisons = Poisons that increase in intensity with increased doses</p> Signup and view all the answers

Experimental evidence is gathered before death to investigate poison effects.

<p>True (A)</p> Signup and view all the answers

Which factor does NOT influence organ toxicity?

<p>Ambient temperature (B)</p> Signup and view all the answers

What characterizes systemic effects of poisons?

<p>Effects affecting the entire body</p> Signup and view all the answers

The primary symptoms of carbon monoxide poisoning include ______ blood.

<p>cherry red</p> Signup and view all the answers

Acute poisoning can lead to disturbances of function or death within a short period of time.

<p>True (A)</p> Signup and view all the answers

Name one genetic defect that may lead to idiosyncratic reactions in drug metabolism.

<p>G6PD deficiency</p> Signup and view all the answers

Which of the following conditions does NOT modify the action of poisons?

<p>Weather (D)</p> Signup and view all the answers

Match the following substances with their corresponding breath odors:

<p>Fruity odor = Ethanol Garlic = As, P, Malathion Bitter Almonds = CN‾ Mouse urine = Coniine</p> Signup and view all the answers

Chronic toxicity refers to the effects of poison that occur over a short period.

<p>False (B)</p> Signup and view all the answers

What is the sign of opium poisoning as it relates to visual disturbances?

<p>Blood Shot Eyes</p> Signup and view all the answers

Undetermined poisoning is characterized by a hazy history regarding how the poison was __________.

<p>obtained</p> Signup and view all the answers

Flashcards

Systemic Toxicity

Harmful effects on vital organs after absorption into the bloodstream following local action.

Routes of Exposure

The ways a substance enters the body, including oral, intravenous, subcutaneous, skin absorption, and inhalation.

Quantitative Toxicity

Measures the dose-response relationship of a substance, measured frequently using LD50, LC50, and TLV.

Acute Poisoning

Rapid onset of poisoning due to a high dose or frequent small doses.

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Chronic Poisoning

Poisoning that develops gradually over a long period of time, leading to progressive tissue damage.

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LD50

Median Lethal Dose - the dose required to kill half the test population.

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LC50

Median Lethal Concentration - the concentration of a substance required to kill half the test population.

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Toxic Effect Classification

Toxic effects categorized as pharmacological, pathological, genotoxic, acute, chronic, immediate, delayed, direct, or indirect.

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Local Poisoning Effects

Damage to the mucous membranes or tissues at the point of contact with a poison.

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Corrosion (Poisoning)

Chemical burning caused by a substance like acids or bases.

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Systemic Poisoning

Poisoning that affects the body's organs after the poison is absorbed.

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Poison Absorption Factors

Factors affecting how quickly a poison enters the bloodstream.

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Solubility of Poison

How easily a substance dissolves in the body's fluids.

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Accidental Poisoning

Unintentional ingestion or exposure to a poisonous substance.

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Homicidal Poisoning

Intentional poisoning with the purpose of killing another person.

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Circumstantial Evidence (Poisoning)

Evidence based on events that suggest poison was involved.

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Post-mortem Evidence (Poisoning)

Evidence of poisoning found after a body is examined.

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Chemical Evidence (Poisoning)

Testing substances to identify a poison in samples.

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Beilstein Test

A test for the presence of halogens (chlorine, etc.) in a substance.

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Blood Changes (Poisoning)

Symptoms of poisoning that can be seen in the blood, like changes in its properties or colour.

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Breath Odor (Poisoning)

Changes in breath smell that may indicate poisoning.

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Skin Discoloration (Poisoning)

Changes in skin color as a possible sign of poisoning.

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Vomit Appearance (Poisoning)

Visual characteristics of vomit that could suggest a poisonous substance.

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Enzyme Induction

A process where repeated exposure to a drug (especially for chain smokers and alcoholics) increases the production of enzymes in the liver. This can lead to faster drug metabolism and reduced effectiveness of the drug.

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Tolerance

When the body adapts to a substance (like nicotine or alcohol) and needs a larger dose to achieve the same effect. This happens because the body can break down the substance faster.

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Idiosyncrasy

An unusual reaction to a drug due to genetic mutations, leading to a lack of enzymes that normally metabolize the drug, potentially resulting in toxicity.

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Cumulative Poisoning

Poisons that build up in the body over time, eventually reaching a level that triggers harmful effects.

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Corrosives

Substances that cause local damage to tissues by burning or destroying them. They are not usually considered poisonous when diluted.

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True Poisons

Substances that are highly toxic and have no medicinal value. They can cause serious harm or death even in small amounts.

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Cumulative Poisons

Substances that become more toxic as the dose increases. They can cause a gradual increase in the intensity of their effects.

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Physical State & Mental State

These factors can influence how the body absorbs, distributes, and metabolizes a substance. For example, someone with a compromised immune system may be more susceptible to poisoning.

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Study Notes

Introduction to Poisons

  • Poisons have a history dating back thousands of years, used for hunting and sometimes as "ordeal poisons."
  • Early poisons were mainly plant and animal toxins, and some minerals.
  • The term "toxicology" comes from the Greek word "toxicon," meaning "poison into which arrowheads are dipped."
  • Common arrow poisons included strophanthin, aconitine, extracts from Helleborus, and snake venom.

Lesson Objectives

  • Categorize poisons by different factors.
  • Classify toxic effects.
  • Identify poisons based on evidence.

Sources of Poisons

  • Industrial pollutants (e.g., hydrocyanic acid, carbon monoxide, chlorofluorocarbons).
  • Household products (e.g., insecticides, pesticides, cleaning agents).
  • Environmental toxins (e.g., lead, sulfur dioxide, ozone).
  • Pharmacologic/medicinal substances (e.g., clinically used drugs, substances for abuse).

Kinds of Poisons

  • Poisoning effects can be local, remote, or a combination of both.
  • Local effects are confined to the area of contact.
  • Remote effects occur in areas other than the point of contact.
  • Combined effects have both local and remote effects.

Factors Affecting Poisoning Effects

  • Poison related factors include solubility, route of administration, and concentration.
  • Patient related factors include age, liver development, and enzyme function.
  • Accidental: Poison taken without intent to harm.
  • Suicidal: Poison taken with intent to harm oneself.
  • Homicidal: Poison given with intent to harm another.
  • Undetermined: The method of obtaining and using poison is unknown.

Evidences of Poisoning

  • Circumstantial: Evidence deduced from events and facts.
  • Symptomatic: Evidence based on the patient's symptoms.
  • Chemical: Evidence from chemical analysis of tissues, organs, and fluids.
  • Ante-mortem: Evidence collected before death.
  • Post-mortem: Evidence collected after death.
  • Experimental: Evidence provided by administering the substance to an animal.

Classification of Toxic Effects

  • Pharmacological
  • Pathological
  • Genotoxic
  • Chronical
  • Acute
    • Immediate (rapid effects)
    • Delayed (effects over time)
    • Direct (caused by the substance)
    • Indirect (effects caused by the direct ones)

Tests to Detect Poisons

  • Various tests exist to detect specific poisons (e.g., Beilstein, Bromine Water, Marquis', etc.) depending on the suspected poison.

Target Organs of Toxicity

  • Circulatory, Liver, Kidney and Lung, CNS (brain and spinal cord), Blood and Hematopoietic system, Muscle and bone and Skin

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