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Questions and Answers
Which of the following is the most important property of an ideal drug?
Which of the following is the most important property of an ideal drug?
What is the primary therapeutic objective of drug therapy?
What is the primary therapeutic objective of drug therapy?
Under the Controlled Substances Act, which DEA schedule has the highest risk for abuse?
Under the Controlled Substances Act, which DEA schedule has the highest risk for abuse?
Which phase of drug development involves the largest sample size for testing the drug's efficacy and monitoring adverse reactions?
Which phase of drug development involves the largest sample size for testing the drug's efficacy and monitoring adverse reactions?
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Which pharmacokinetic process involves the removal of drugs from the body?
Which pharmacokinetic process involves the removal of drugs from the body?
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A nurse administering medications is the last line of defense to ensure patient safety. What is the nurse's primary responsibility in this role?
A nurse administering medications is the last line of defense to ensure patient safety. What is the nurse's primary responsibility in this role?
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What is the primary process by which most drugs cross cell membranes during absorption?
What is the primary process by which most drugs cross cell membranes during absorption?
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Which route of drug administration typically results in the fastest absorption?
Which route of drug administration typically results in the fastest absorption?
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What factor influences whether a drug is lipid-soluble or water-soluble during absorption?
What factor influences whether a drug is lipid-soluble or water-soluble during absorption?
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Where is an acidic drug most likely absorbed in the gastrointestinal tract?
Where is an acidic drug most likely absorbed in the gastrointestinal tract?
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Which of the following drugs is most likely to cross the blood-brain barrier?
Which of the following drugs is most likely to cross the blood-brain barrier?
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Which of the following statements about P-glycoprotein is correct?
Which of the following statements about P-glycoprotein is correct?
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Which pharmaceutical preparation dissolves in the intestine rather than the stomach?
Which pharmaceutical preparation dissolves in the intestine rather than the stomach?
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What happens to a basic drug in the acidic environment of the stomach?
What happens to a basic drug in the acidic environment of the stomach?
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Which factor is not a determinant of drug absorption?
Which factor is not a determinant of drug absorption?
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What term describes the accumulation of drugs on the side of a membrane where the pH favors ionization?
What term describes the accumulation of drugs on the side of a membrane where the pH favors ionization?
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What is the primary site for drug absorption following oral administration?
What is the primary site for drug absorption following oral administration?
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Which factor most significantly impacts the bioavailability of a drug?
Which factor most significantly impacts the bioavailability of a drug?
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Why should enteric-coated tablets not be crushed or chewed?
Why should enteric-coated tablets not be crushed or chewed?
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Which type of drug passes most easily through the lipid cell membranes?
Which type of drug passes most easily through the lipid cell membranes?
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What effect does fatty food have on the absorption of oral drugs?
What effect does fatty food have on the absorption of oral drugs?
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Which preparation of a drug is generally more bioavailable?
Which preparation of a drug is generally more bioavailable?
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Which of the following statements about drug absorption is correct?
Which of the following statements about drug absorption is correct?
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Why is insulin not administered orally?
Why is insulin not administered orally?
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What happens to a drug in a sustained-release form if it is crushed before administration?
What happens to a drug in a sustained-release form if it is crushed before administration?
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Which of the following factors can delay drug absorption in the gastrointestinal (G.I.) tract?
Which of the following factors can delay drug absorption in the gastrointestinal (G.I.) tract?
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Study Notes
Intro to Pharmacy
- Ideal Drug Property: Effectiveness is the most important property
- Therapeutic Objective: To provide maximum benefit with minimal harm
- Schedule I Drugs: Highest risk for abuse (e.g., heroin)
- Phase III Trials: Involve the largest sample size for testing efficacy and monitoring adverse reactions
- Generic Names: Preferred for safety in written/oral communication as they are standardized and non-proprietary, reducing confusion
Pharmacokinetics
- Absorption: The primary process by which most drugs cross cell membranes to enter the bloodstream, using passive diffusion.
- Fastest Absorption Route: Intravenous administration
- Factors influencing Drug Absorption: Ionization state (lipid-soluble vs water-soluble)
Drug Absorption Locations
- Stomach: Acidic environment where acidic drugs are best absorbed
- Small Intestine: Primary site for absorption due to large surface area (folds and villi)
Drug Names and Preparation
- Enteric-coated tablets: Designed to dissolve in the intestine, not in the stomach. Crushing them can cause rapid release and overdose potential
- Absorption and Bioavailability: Type of preparation influences bioavailability. Solubility/Dissolvability: Soluble liquid forms more bioavailable.
Other Key Concepts
- P-glycoprotein: Transports drugs out of cells, reducing absorption
- Ion Trapping: Drug accumulation on the side of a membrane where pH favors ionization (makes the drug less able to cross the membrane).
- Drug Absorption factors: blood flow to the absorption site, rate of dissolution, and surface area for absorption.
- Bioavailability: influenced by drug preparation type, impacting absorption
- Insulin Administration: Not administered orally because it's broken down by digestive enzymes in the stomach.
- Prolonged Fasting: Can cause vasoconstriction of blood vessels in the GI tract, slowing drug absorption.
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Description
This quiz covers essential concepts in pharmacy including drug properties, therapeutic objectives, and pharmacokinetics. It delves into drug absorption mechanisms and locations, providing a comprehensive look at the foundational knowledge required for pharmacy studies. Ideal for students and professionals alike.
