Jersey College Pharmacology Week 1
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Questions and Answers

What is the use of drugs to prevent, diagnose, or treat signs, symptoms, and disease processes called?

  • Medication Therapy
  • Pharmacology
  • Pharmacotherapy (correct)
  • Drug Therapy

Which of the following is NOT a source of drugs?

  • Animals
  • Synthetic compounds (correct)
  • Plants
  • Minerals

What is the main difference between local and systemic effects of medications?

  • Systemic medications are not absorbed into the bloodstream.
  • Local medications are applied directly to the site of action.
  • Systemic medications are absorbed into the bloodstream. (correct)
  • Local medications are absorbed into the bloodstream.

Which of these is NOT commonly used to classify drugs?

<p>Frequency of Use (D)</p> Signup and view all the answers

Which of these is a TRUE statement?

<p>Medications are drugs given for therapeutic purposes. (A)</p> Signup and view all the answers

What is the primary reason why pharmacological knowledge is essential for healthcare professionals?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is NOT a way to classify drugs?

<p>By their dosage forms (B)</p> Signup and view all the answers

Which of the following is a common characteristic of both local and systemic medications?

<p>They both can have unintended side effects. (C)</p> Signup and view all the answers

Which Act specifically regulates the manufacturing and distribution of controlled substances?

<p>Comprehensive Drug Abuse Prevention and Control Act (C)</p> Signup and view all the answers

Which of the given acts establishes the criteria for purity and strength of drugs?

<p>Food, Drug, and Cosmetic Act of 1938 (C)</p> Signup and view all the answers

The Drug Enforcement Administration (DEA) is primarily responsible for:

<p>Enforcing the Controlled Substances Act (D)</p> Signup and view all the answers

Which agency is directly involved in the approval process for new prescription drugs?

<p>U.S. Food and Drug Administration (FDA) (C)</p> Signup and view all the answers

Which act determines which medications require a prescription from a healthcare professional?

<p>Durham-Humphrey Amendment (A)</p> Signup and view all the answers

Which agency is primarily responsible for ensuring the safety and efficacy of drugs?

<p>FDA (A)</p> Signup and view all the answers

The Controlled Substances Act can be found under which title of the Comprehensive Drug Abuse Prevention and Control Act?

<p>Title II (C)</p> Signup and view all the answers

How many categories of controlled substances are defined by the Controlled Substances Act?

<p>5 (C)</p> Signup and view all the answers

What are prototypes in the context of drug classifications?

<p>Individual drugs that are exemplars of a drug class. (A)</p> Signup and view all the answers

Which of the following drugs is a prototype for opioid analgesics?

<p>Morphine (C)</p> Signup and view all the answers

What type of drug name often represents the chemical composition?

<p>Generic name (D)</p> Signup and view all the answers

Why does using different drug names increase the risk of misuse?

<p>Confusion between generic and brand names may occur. (C)</p> Signup and view all the answers

What is required before drugs can be marketed in the United States?

<p>They must meet specific testing standards (C)</p> Signup and view all the answers

Are over-the-counter (OTC) medications regulated by law?

<p>Yes, they are regulated by various drug laws. (A)</p> Signup and view all the answers

Which healthcare professional is legally able to write prescriptions?

<p>Physician assistant (D)</p> Signup and view all the answers

Which organization is responsible for approving new drugs in the U.S.?

<p>Food and Drug Administration (FDA) (B)</p> Signup and view all the answers

What is a potential action that the FDA can take regarding prescription drugs?

<p>Change their status to over-the-counter (OTC) (C)</p> Signup and view all the answers

Which law requires that official drugs meet standards of purity and strength?

<p>Food, Drug, and Cosmetic Act of 1938 (A)</p> Signup and view all the answers

What distinguishes nonprescription (OTC) drugs from prescription drugs?

<p>Prescription drugs are written by licensed healthcare providers. (A)</p> Signup and view all the answers

Which of the following is included in the National Patient Safety Goals?

<p>‘Do Not Use’ list of unacceptable abbreviations (B)</p> Signup and view all the answers

Which of the following is a less authoritative source of drug information?

<p>Physicians’ Desk Reference (PDR) (D)</p> Signup and view all the answers

What is the focus of the QSEN initiative related to drug administration?

<p>Quality and safety education for healthcare professionals (A)</p> Signup and view all the answers

In studying pharmacology, what is recommended when taking notes?

<p>Use one's own words to summarize drug information (A)</p> Signup and view all the answers

What does 'Beers Criteria' refer to in the context of medication safety?

<p>Criteria for high-alert medications in older adults (D)</p> Signup and view all the answers

Which of these actions is NOT a primary function of cells?

<p>Eliminating waste products from the body (C)</p> Signup and view all the answers

What is the main reason why drugs need to cross cell membranes?

<p>To reach their target site and exert their effects (D)</p> Signup and view all the answers

Which of the following is NOT a common characteristic shared by all cells?

<p>Having a rigid cell wall for structural support (C)</p> Signup and view all the answers

Which pathway refers to the transport of drugs throughout the body, allowing them to reach their intended target?

<p>Systemic Transport (C)</p> Signup and view all the answers

Which of the following is NOT a way in which cells communicate with each other?

<p>Via the exchange of genetic material (D)</p> Signup and view all the answers

What is the primary purpose of drug transport pathways and mechanisms?

<p>To deliver drugs to their intended target sites (D)</p> Signup and view all the answers

Which of the following statements is TRUE about cells?

<p>Cells are highly specialized and perform unique functions (D)</p> Signup and view all the answers

What is the key requirement for a drug to effectively stimulate or inhibit cellular function?

<p>To reach and interact with the cell membrane (C)</p> Signup and view all the answers

Which of the following is NOT a factor that influences serum drug level?

<p>Route of administration (C)</p> Signup and view all the answers

Which of the following is NOT a mechanism by which drugs can exert their effects through receptor binding?

<p>Directly altering DNA structure (D)</p> Signup and view all the answers

Which of the following is NOT an example of a drug that acts through nonreceptor mechanisms?

<p>Antibiotics (D)</p> Signup and view all the answers

What is the minimum effective concentration (MEC) of a drug?

<p>The concentration of drug required to achieve clinical efficacy (A)</p> Signup and view all the answers

Which of the following is NOT a way that toxic concentration of a drug can occur?

<p>Rapid excretion of the drug from the body (C)</p> Signup and view all the answers

Which of the following BEST describes the action of an agonist drug?

<p>It enhances or mimics the action of a naturally occurring substance (D)</p> Signup and view all the answers

Which of the following is a TRUE statement about drug half-life?

<p>It refers to the time it takes for the drug concentration in the blood to decrease by 50% (B)</p> Signup and view all the answers

Which of the following BEST describes the role of bioavailability in drug action?

<p>It refers to the amount of drug that reaches the target tissue (C)</p> Signup and view all the answers

Which of the following drug-related variables can influence the absorption and distribution of a medication?

<p>Route of administration (D)</p> Signup and view all the answers

Which of the following is NOT an example of a drug-related interaction that can increase therapeutic or adverse effects?

<p>Antidote medication (C)</p> Signup and view all the answers

Which of these can decrease the therapeutic or adverse effects of a drug?

<p>Increased metabolism rate of drugs (A), Decreased intestinal absorption of drugs (D)</p> Signup and view all the answers

Which of the following is a patient-related variable that can significantly influence drug response?

<p>Pharmacogenomics (C)</p> Signup and view all the answers

Which of the following statements about adverse effects of drugs is TRUE?

<p>All drugs can potentially produce adverse effects. (D)</p> Signup and view all the answers

Which of the following is NOT a type of adverse effect that can occur with drug administration?

<p>Synergistic effects (A)</p> Signup and view all the answers

Which of the following BEST describes pharmacogenomics?

<p>The study of how genetic variations affect drug response (D)</p> Signup and view all the answers

What are boxed warnings intended to do?

<p>Highlight the most serious adverse effects of a drug (C)</p> Signup and view all the answers

What can result from an overdose of medication?

<p>Damaged body tissues (D)</p> Signup and view all the answers

Which of the following scenarios can lead to an overdose?

<p>Injesting a single large dose of medication (D)</p> Signup and view all the answers

What is one of the main goals when treating an overdose?

<p>To support and stabilize vital functions (B)</p> Signup and view all the answers

What may be involved in a drug overdose aside from prescription drugs?

<p>Alcohol and over-the-counter medications (A)</p> Signup and view all the answers

Which action is NOT typically taken to prevent further harm from an overdose?

<p>Increasing drug absorption (B)</p> Signup and view all the answers

What is the primary purpose of biotransformation in drug metabolism?

<p>To alter drugs from their original form into a new form (A)</p> Signup and view all the answers

Which organs are primarily involved in drug metabolism?

<p>Liver and gastrointestinal mucosa (A)</p> Signup and view all the answers

What effect does enzyme induction have on drug metabolism?

<p>It accelerates the rate of drug metabolism (B)</p> Signup and view all the answers

What is meant by prodrugs in pharmacology?

<p>Inactive compounds that become active upon metabolism (D)</p> Signup and view all the answers

Which system must function adequately for the excretion of medications from the body?

<p>Circulatory system (B)</p> Signup and view all the answers

How does absorption differ from distribution in pharmacology?

<p>Absorption refers to drug intake, while distribution refers to drug transport within the body (D)</p> Signup and view all the answers

Which factors can slow down drug metabolism?

<p>Enzyme inhibition and certain medications (A)</p> Signup and view all the answers

What is the primary role of drug-metabolizing enzymes in the body?

<p>To break down medications for excretion (C)</p> Signup and view all the answers

Which of these factors does NOT directly influence the rate and extent of drug absorption?

<p>Patient's mood (A)</p> Signup and view all the answers

What is the primary function of distribution in pharmacokinetics?

<p>Transporting drug molecules to various sites within the body (A)</p> Signup and view all the answers

Which of the following is NOT directly influenced by the distribution process?

<p>The onset of drug action (C)</p> Signup and view all the answers

Why is protein binding an important factor in drug distribution?

<p>It determines the amount of free drug available to exert its effects (B)</p> Signup and view all the answers

How does the blood-brain barrier affect drug distribution?

<p>It prevents most drugs from entering the brain and cerebrospinal fluid (A)</p> Signup and view all the answers

Which of these statements accurately describes the relationship between pharmacokinetics and drug action?

<p>Pharmacokinetics determines the rate of drug absorption, while pharmacodynamics determines the duration of drug action (B)</p> Signup and view all the answers

What is the significance of the GI function in drug absorption?

<p>GI function can affect the rate and extent of drug absorption (B)</p> Signup and view all the answers

Which of the following best describes the role of metabolism in pharmacokinetics?

<p>Metabolism increases the drug's water solubility, facilitating its excretion (C)</p> Signup and view all the answers

What is the primary purpose of controlled-release medication delivery systems?

<p>To release medication gradually over an extended period. (A)</p> Signup and view all the answers

What are some common examples of medications that are often delivered through pump delivery systems?

<p>Insulin, opioid analgesics, and anticancer medications. (B)</p> Signup and view all the answers

Which of the following correctly represents the formula for calculating medication dosages?

<p>D = X x H / V (A)</p> Signup and view all the answers

What does the variable 'V' represent in the medication dosage calculation formula?

<p>The volume or unit of the medication. (B)</p> Signup and view all the answers

Which of the following medication delivery systems is NOT typically used for local treatments?

<p>Controlled-release tablets (B)</p> Signup and view all the answers

Which of the following is a common characteristic of both local and systemic medication effects?

<p>They both involve the medication entering the bloodstream. (A)</p> Signup and view all the answers

What is the primary reason why accuracy is extremely important when calculating medication dosages?

<p>All of the above. (D)</p> Signup and view all the answers

Which of the following is NOT a factor that is typically considered when calculating medication dosages?

<p>The patient's occupation. (D)</p> Signup and view all the answers

Which of the following methods for order transcription is considered the least prone to errors and is the preferred method?

<p>Computer entry (C)</p> Signup and view all the answers

What is the primary reason for using generic names of medications in medication orders?

<p>To avoid confusion with brand names, which could lead to medication errors. (C)</p> Signup and view all the answers

What is the main purpose of medication reconciliation in preventing medication errors?

<p>To identify and resolve any discrepancies in medication lists between different care settings. (C)</p> Signup and view all the answers

Which of the following actions is NOT directly aimed at preventing medication errors in healthcare facilities?

<p>Encouraging the use of abbreviations to shorten medication orders (C)</p> Signup and view all the answers

What is the primary goal of the computerized, locked cabinets used in some healthcare facilities?

<p>To ensure the security and accountability of medications, particularly controlled substances. (B)</p> Signup and view all the answers

Which of the following is NOT a component of a complete medication order as described in the given content?

<p>The prescriber's professional license number (A)</p> Signup and view all the answers

Which of these best describes the primary benefit of limiting the use of abbreviations in medication orders?

<p>It reduces the risk of misinterpretations that can lead to medication errors. (C)</p> Signup and view all the answers

Why is it important for nurses to be familiar with commonly used abbreviations?

<p>To ensure that they understand the content of medication orders from physicians. (A)</p> Signup and view all the answers

What is the primary method of administration for medications classified as parenteral?

<p>Injections into a muscle or vein (B)</p> Signup and view all the answers

Which type of syringe may come prefilled with medication?

<p>Prefilled syringe (A)</p> Signup and view all the answers

What influence does the gauge of a syringe have?

<p>It indicates the thickness of the solution being administered. (D)</p> Signup and view all the answers

What condition is REQUIRED for medications intended for injection?

<p>They must maintain sterility. (C)</p> Signup and view all the answers

What is a common route of administration for topical medications?

<p>Application to skin or mucous membranes (C)</p> Signup and view all the answers

How does the route of administration affect medication delivery?

<p>It can influence absorption rate and effectiveness. (C)</p> Signup and view all the answers

Which of the following statements about the parenteral route is FALSE?

<p>It involves topical application of medication. (A)</p> Signup and view all the answers

Which type of container is NOT typically used for medications designed for injection?

<p>Plastic bottles (C)</p> Signup and view all the answers

What is the primary function of the nursing process in drug therapy?

<p>To provide a systematic approach for individualized patient care (D)</p> Signup and view all the answers

Which of the following elements is NOT part of the nursing process?

<p>Social assessment (C)</p> Signup and view all the answers

Which aspect is considered during the assessment phase of the nursing process?

<p>Determining the patient's current medications and history (D)</p> Signup and view all the answers

What role does patient teaching play in drug therapy?

<p>It enhances the therapeutic effects and reduces adverse effects. (D)</p> Signup and view all the answers

What is the goal of promoting general nondrug interventions in drug therapy?

<p>To prevent or decrease the necessity for drug therapy (D)</p> Signup and view all the answers

Which patient factor is essential to evaluate before initiating drug therapy?

<p>The patient's ability to verbalize medication knowledge (B)</p> Signup and view all the answers

During which phase of the nursing process is individualized care primarily established?

<p>Planning/establishing goals (D)</p> Signup and view all the answers

Which statement accurately reflects the importance of the nursing process in drug therapy?

<p>It facilitates a comprehensive approach to safeguard patient care. (B)</p> Signup and view all the answers

Which of the following is NOT a common site for subcutaneous (Sub-Q) injections?

<p>Forearms (B)</p> Signup and view all the answers

Which of the following injection sites requires a physician to administer the injection?

<p>Intra-articular (C)</p> Signup and view all the answers

What is the primary reason why needleless systems were developed?

<p>To prevent injury and the spread of blood-borne pathogens (C)</p> Signup and view all the answers

Which of the following is NOT a common site for intravenous (IV) injections?

<p>Deltoid (A)</p> Signup and view all the answers

What is the purpose of syringes in medication administration?

<p>To measure doses accurately and administer medications (B)</p> Signup and view all the answers

Which of the following injections is typically administered into the layers of skin?

<p>Intradermal (D)</p> Signup and view all the answers

Which of the following injection sites requires specific expertise and is usually administered by a physician?

<p>Intrathecal (B)</p> Signup and view all the answers

Which of the following statements is TRUE regarding syringes?

<p>Syringes are calibrated to measure doses accurately (B)</p> Signup and view all the answers

What is the primary goal of evaluating drug therapy outcomes?

<p>To monitor for potential adverse effects and ensure the medication is working as intended. (B)</p> Signup and view all the answers

Which of these is NOT a factor that influences serum drug level?

<p>Administration of other medications. (B)</p> Signup and view all the answers

Which of the following is the BEST description of the action of an agonist drug?

<p>A drug that binds to a receptor and stimulates a response. (B)</p> Signup and view all the answers

Which of the following are mechanisms of microbial resistance to medications?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is NOT a host defense mechanism that can impair the body's ability to fight off infections?

<p>Enhanced immune response (D)</p> Signup and view all the answers

Which of these is an example of a Host Defense Mechanism impairment that can increase the risk of infection?

<p>Suppression of immune system (A)</p> Signup and view all the answers

Which of the following is a contributing factor to the high rates of antimicrobial resistance associated with lower respiratory tract infections and infections related to cystic fibrosis or osteomyelitis?

<p>These infections often involve multiple organisms, making it more challenging to eliminate them. (A)</p> Signup and view all the answers

Which of the following would be considered a Host Defense Mechanism impairment?

<p>Insertion of prosthetic devices (A)</p> Signup and view all the answers

Which of the following would be considered a Host Defense Mechanism?

<p>Mechanical movements (D)</p> Signup and view all the answers

Why is the suppression of normal flora via antimicrobials considered a Host Defense Mechanism impairment?

<p>It weakens the immune system, making it more susceptible to infections. (B)</p> Signup and view all the answers

Which of these is not a host defense mechanism impairment?

<p>Mechanical movements (C)</p> Signup and view all the answers

Which of the following is NOT a reason for using combination therapy of antimicrobials according to the guidelines?

<p>Treatment of chronic diseases (C)</p> Signup and view all the answers

When selecting an older, more cost-effective drug, which guideline is being followed?

<p>Cost (C)</p> Signup and view all the answers

According to the guidelines, which of the following factors influences the route of administration (oral or IV) for systemic infections?

<p>Severity of infection (C), Patient's ability to take oral medications (D)</p> Signup and view all the answers

Which of the following is NOT a special population that requires special considerations for antimicrobial therapy?

<p>Individuals with diabetes (A)</p> Signup and view all the answers

What is the recommended duration of antimicrobial therapy for an acute infection?

<p>7 to 10 days (C)</p> Signup and view all the answers

What is the PRIMARY reason why hospital-acquired infections might be more severe and difficult to manage?

<p>They often involve drug-resistant microbes. (B)</p> Signup and view all the answers

What is the main difference between antimicrobial therapy use guidelines #1 and #2?

<p>Guideline #1 focuses on types of infections, while guideline #2 focuses on route of administration. (C)</p> Signup and view all the answers

Which of the following is NOT mentioned as a factor that could influence the duration of antimicrobial therapy?

<p>Patient age (C)</p> Signup and view all the answers

What are opportunistic pathogens typically associated with?

<p>Increased growth in severely burned patients (A)</p> Signup and view all the answers

Which of the following statements is true regarding laboratory identification of pathogens?

<p>Microbial culture helps in identifying drug-resistant bacteria (B)</p> Signup and view all the answers

What can predispose an individual to opportunistic infections?

<p>Use of intravenous catheters (A)</p> Signup and view all the answers

What is one reason why bacterial infections can be life-threatening?

<p>They can involve drug-resistant microorganisms (D)</p> Signup and view all the answers

Which factor can lead to the overgrowth of opportunistic pathogens?

<p>Use of broad-spectrum antibiotics (C)</p> Signup and view all the answers

In which scenario are opportunistic infections most likely to occur?

<p>In patients receiving immunosuppressive therapy (A)</p> Signup and view all the answers

What is the primary clinical significance of the Gram stain procedure?

<p>It identifies the microscopic appearance of bacteria (B)</p> Signup and view all the answers

What distinguishes opportunistic pathogens from regular pathogens?

<p>Opportunistic pathogens can cause disease in compromised hosts (D)</p> Signup and view all the answers

What is the purpose of serology in laboratory tests?

<p>IDs infectious agent via antibody levels (A)</p> Signup and view all the answers

What is a significant consequence of infections caused by antibiotic-resistant microorganisms?

<p>Increase mortality rates (C)</p> Signup and view all the answers

How can antibiotic-resistant microorganisms emerge in a host?

<p>By exposure to broad-spectrum antibiotics (C)</p> Signup and view all the answers

What is the mechanism that leads to the predominance of resistant strains of microorganisms?

<p>Use of broad-spectrum antibiotics that suppress normal flora (B)</p> Signup and view all the answers

Which type of infection is often associated with high rates of antimicrobial resistance?

<p>Lower respiratory tract infections (B)</p> Signup and view all the answers

What can result from antibiotic usage that can promote superinfections?

<p>Interruption of or inadequate antimicrobial treatment (B)</p> Signup and view all the answers

What role do immunosuppressive disorders play in antibiotic resistance?

<p>They allow for the development of microbial resistance (B)</p> Signup and view all the answers

What is a consequence of antibiotic misuse and mismanagement in patients?

<p>Development of multi-drug resistant organisms (C)</p> Signup and view all the answers

What is the mechanism by which antimicrobials often act on bacterial cells?

<p>Inhibition of bacterial wall synthesis (D)</p> Signup and view all the answers

Which of the following terms describes an antimicrobial that is effective against a wide range of microorganisms?

<p>Broad spectrum (D)</p> Signup and view all the answers

What is a potential outcome of the misuse and overuse of antimicrobials?

<p>Development of drug-resistant infections (B)</p> Signup and view all the answers

What type of antimicrobial action destroys bacteria directly?

<p>Bactericidal (D)</p> Signup and view all the answers

When are antimicrobial medications necessary?

<p>When the host's immune system is compromised, leading to ineffective defenses. (A)</p> Signup and view all the answers

What is the primary reason why normal microbial flora, like those found on skin, can become a threat to health?

<p>They can be suppressed by antibiotic therapy, allowing potential pathogens to proliferate. (D)</p> Signup and view all the answers

Which characteristic is essential for the rational use of antimicrobials?

<p>Eradication of the causative microorganism (D)</p> Signup and view all the answers

What is a common approach of broad-spectrum antibiotics compared to narrow-spectrum antibiotics?

<p>Act against a wider variety of bacteria (B)</p> Signup and view all the answers

Which of the following groups is MOST susceptible to developing infections from normal flora?

<p>Older adult patients with compromised immune systems (B)</p> Signup and view all the answers

Which of the following statements accurately describes how microorganisms, like bacteria, thrive in the body?

<p>They attach to host cells, invade tissues, multiply, and produce infection. (A)</p> Signup and view all the answers

Which statement accurately describes a bacteriostatic antimicrobial?

<p>It prevents bacterial reproduction. (A)</p> Signup and view all the answers

The goal of antimicrobial therapy is primarily to achieve which of the following?

<p>Return host to full physiologic function (C)</p> Signup and view all the answers

Identify the classification of microorganisms that is NOT typically targeted by antimicrobial medications.

<p>Viruses (B)</p> Signup and view all the answers

What is the MAIN reason why antimicrobial medications are NOT effective against all microorganisms?

<p>Antimicrobial medications only target specific types of microorganisms. (B)</p> Signup and view all the answers

What is a potential consequence of suppressing normal flora with antimicrobial therapy?

<p>Increased risk of infections caused by potential pathogens that were previously inhibited by the normal flora. (C)</p> Signup and view all the answers

Which of the following BEST describes the key role of normal microbial flora in maintaining health?

<p>They compete with potential pathogens for resources and space, thus preventing infection. (C)</p> Signup and view all the answers

Which of the following statements BEST describes the relationship between prostaglandins and inflammation?

<p>Prostaglandins play a role in both causing and reducing inflammation. (A)</p> Signup and view all the answers

What is the primary mechanism by which NSAIDs relieve fever?

<p>By reducing the sensitivity of the hypothalamus to pyrogens. (C)</p> Signup and view all the answers

Which of the following statements BEST describes the role of COX-1 and COX-2 enzymes in prostaglandin synthesis?

<p>COX-1 and COX-2 are both involved in the production of prostaglandins, but COX-2 is more selective in its activity. (A)</p> Signup and view all the answers

Which of these is NOT a way NSAIDs are used to reduce pain?

<p>NSAIDs directly inhibit the production of endorphins, which are natural pain relievers. (D)</p> Signup and view all the answers

How does the use of aspirin differ from non-aspirin NSAIDs in terms of their effects on the cardiovascular system?

<p>Aspirin has an antiplatelet effect that is not shared by other NSAIDs. (D)</p> Signup and view all the answers

Why does acetaminophen (Tylenol) not have anti-inflammatory properties?

<p>Acetaminophen does not inhibit COX-1 or COX-2 enzymes. (B)</p> Signup and view all the answers

Which of the following accurately describes the relationship between prostaglandins and fever?

<p>Prostaglandins cause fever by increasing the set point of the body's thermostat. (D)</p> Signup and view all the answers

Which of these is NOT a factor that influences the effects of NSAIDs?

<p>The patient's genetic predisposition to certain inflammatory responses (D)</p> Signup and view all the answers

Which of the following is NOT a class of nonsteroidal anti-inflammatory drugs (NSAIDs)?

<p>Sulfa derivatives (B)</p> Signup and view all the answers

Which of the following statements accurately describes the anti-inflammatory properties of acetaminophen?

<p>Acetaminophen lacks anti-inflammatory properties but can be used as an analgesic. (C)</p> Signup and view all the answers

Which of the following is a characteristic of selective COX-2 inhibitor drugs?

<p>They selectively block production of prostaglandins associated with pain and inflammation without blocking those associated with protective effects on gastric mucosa, kidney function, and platelet aggregation. (A)</p> Signup and view all the answers

Which of the following is NOT a condition that NSAIDs are commonly used to treat or prevent?

<p>Migraines (C)</p> Signup and view all the answers

Which of the following is a common characteristic of both propionic acid derivatives and oxicam derivatives of NSAIDs?

<p>They both inhibit prostaglandin synthesis in both the central and peripheral nervous systems. (C)</p> Signup and view all the answers

Which of the following statements is TRUE regarding acetaminophen poisoning?

<p>Acetaminophen poisoning can occur with a single large dose or with chronic ingestion of excessive doses. (C)</p> Signup and view all the answers

Which of the following best describes the main difference between acetaminophen and other NSAIDs?

<p>Acetaminophen lacks anti-inflammatory properties unlike NSAIDs. (D)</p> Signup and view all the answers

Which of the following is an example of a selective COX-2 inhibitor drug?

<p>Celecoxib (B)</p> Signup and view all the answers

Which of the following conditions is NOT a potential risk associated with NSAID use during pregnancy?

<p>Increased risk of gout (A)</p> Signup and view all the answers

What is the primary mechanism of action of colchicine in the treatment of gout?

<p>It reduces the inflammatory response to urate crystals in the tissues. (B)</p> Signup and view all the answers

What is allopurinol's primary mechanism of action in the management of gout?

<p>It directly blocks the synthesis of uric acid in the body. (A)</p> Signup and view all the answers

Which of the following describes a potential risk associated with NSAID use during pregnancy that could lead to anemia?

<p>Gastrointestinal blood loss. (A)</p> Signup and view all the answers

Which of the following is NOT a potential risk to the fetus associated with NSAID use during pregnancy?

<p>Potential for postpartum hemorrhage (C)</p> Signup and view all the answers

Which type of pain is NSAID not recommended to treat?

<p>Visceral pain (A)</p> Signup and view all the answers

What is a common indication for low-dose ASA treatment?

<p>History of ischemic stroke (A)</p> Signup and view all the answers

What condition contraindicates the use of NSAIDs?

<p>Peptic ulcer disease (B)</p> Signup and view all the answers

Why is ASA not recommended for children?

<p>Risk of Reye syndrome (D)</p> Signup and view all the answers

Which of the following statements about NSAID use in patients with existing conditions is true?

<p>NSAIDs may increase the risk of serious GI adverse events. (D)</p> Signup and view all the answers

What type of pain are NSAIDs and acetaminophen effective in treating?

<p>Acute pain (D)</p> Signup and view all the answers

Which outcome can regular low-dose ASA help prevent?

<p>Heart attack recurrence (D)</p> Signup and view all the answers

What is a potential risk factor for the use of NSAIDs?

<p>Gastric bleeding (B)</p> Signup and view all the answers

What is the main mechanism by which aspirin reduces fever?

<p>Acting on the hypothalamus (C)</p> Signup and view all the answers

Which of the following is a potential adverse effect associated with the use of acetaminophen at therapeutic doses?

<p>Liver damage in individuals who abuse alcohol (D)</p> Signup and view all the answers

What is the primary action of acetylcysteine in the treatment of acetaminophen overdose?

<p>Stimulating the production of glutathione, a key enzyme involved in detoxification (C)</p> Signup and view all the answers

What is the recommended maximum daily dose of acetaminophen from all sources?

<p>4 g (4000 mg) (B)</p> Signup and view all the answers

Which of the following is NOT a potential sign or symptom of acetaminophen overdose?

<p>Suppressed blood clotting (C)</p> Signup and view all the answers

How long after ingestion of acetaminophen is gastric lavage most effective in reducing overdose risk?

<p>4 hours (D)</p> Signup and view all the answers

What is the most effective time window for administering acetylcysteine to treat acetaminophen overdose?

<p>Within 8 hours of ingestion (C)</p> Signup and view all the answers

Which of the following statements is TRUE regarding the use of aspirin for the management of cardiovascular disease?

<p>Low doses are indicated to manage acute myocardial infarction. (C)</p> Signup and view all the answers

Which of the following is NOT a stimulus that can activate the corticosteroid secretion system?

<p>Sleep (C)</p> Signup and view all the answers

What type of corticosteroid is primarily responsible for regulating blood sugar levels?

<p>Glucocorticoids (B)</p> Signup and view all the answers

What is the primary function of the adrenal cortex in the corticosteroid secretion system?

<p>Produce and release corticosteroid hormones (C)</p> Signup and view all the answers

Which of the following statements accurately describes the negative feedback mechanism in the corticosteroid secretion system?

<p>High levels of corticosteroid hormones inhibit the release of ACTH (D)</p> Signup and view all the answers

Which of the following is NOT one of the three main types of endogenous corticosteroids?

<p>Prostaglandins (A)</p> Signup and view all the answers

Which of the following statements is TRUE about the chemical structure of corticosteroid types?

<p>Slight differences in chemical structures lead to different functionalities (C)</p> Signup and view all the answers

What is the primary role of mineralocorticoids in the body?

<p>Maintaining electrolyte balance (A)</p> Signup and view all the answers

What is the significance of corticosteroids being derived from cholesterol?

<p>It suggests they share a common origin with other steroid hormones. (D)</p> Signup and view all the answers

What is the primary function of mineralocorticoids in the body?

<p>Maintain fluid-electrolyte balance (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of glucocorticoids?

<p>They primarily influence salt and water metabolism (B)</p> Signup and view all the answers

What is the main effect of excessive androgen secretion in women?

<p>Development of secondary male characteristics (A)</p> Signup and view all the answers

Which of these statements accurately describes the secretion pattern of endogenous corticosteroids?

<p>They are secreted in the largest amount upon awakening (C)</p> Signup and view all the answers

Which of these is NOT a function of the adrenal sex hormones?

<p>Regulation of fluid-electrolyte balance (A)</p> Signup and view all the answers

Which of these is a TRUE statement regarding the role of androgens in women?

<p>They can cause masculinizing effects when secreted in excess (B)</p> Signup and view all the answers

Which of these is a characteristic of estrogens and progesterone in men?

<p>Excessive secretion can cause feminizing effects (D)</p> Signup and view all the answers

Which of the following statements accurately describes the relationship between endogenous corticosteroids and their types?

<p>Glucocorticoids are the most prevalent type of endogenous corticosteroids (C)</p> Signup and view all the answers

What is a key contraindication for using exogenous corticosteroids?

<p>Hypertension (C)</p> Signup and view all the answers

Which condition may be masked by the use of exogenous corticosteroids?

<p>Infection symptoms (A)</p> Signup and view all the answers

Exogenous corticosteroids are indicated for which of the following conditions?

<p>Rheumatic disorders (C)</p> Signup and view all the answers

What is the primary reason to use exogenous corticosteroids at small doses?

<p>To store normal function (D)</p> Signup and view all the answers

Which factor may increase the risk related to the use of exogenous corticosteroids?

<p>Diabetes Mellitus (D)</p> Signup and view all the answers

In which scenario would the use of exogenous corticosteroids be most risky?

<p>A patient with peptic ulcer disease (A)</p> Signup and view all the answers

Which of the following best describes the pharmacologic effects of high doses of exogenous corticosteroids?

<p>To create new effects not seen with physiologic doses (C)</p> Signup and view all the answers

Why should exogenous corticosteroids be used cautiously in patients with infections?

<p>They can mask signs and symptoms. (B)</p> Signup and view all the answers

What is the primary benefit of local administration of corticosteroids?

<p>Reduces the risk of systemic toxicity (A)</p> Signup and view all the answers

What route of administration is preferred for corticosteroids?

<p>Oral route (B)</p> Signup and view all the answers

What is one of the primary goals of corticosteroid therapy?

<p>Reduce symptoms to a tolerable level (D)</p> Signup and view all the answers

Which of the following is NOT a desired effect of glucocorticoids?

<p>Antipyretic (C)</p> Signup and view all the answers

What is the concern associated with long-term administration of high doses of corticosteroids?

<p>Loss of adrenocortical function (D)</p> Signup and view all the answers

When corticosteroids are administered for acute situations, how are the doses typically managed?

<p>Large doses for a short duration followed by tapering (A)</p> Signup and view all the answers

What is a crucial factor in the selection of a corticosteroid for therapy?

<p>The required route of administration (A)</p> Signup and view all the answers

What is the recommended dosage approach for corticosteroids?

<p>Use the smallest effective dose for the shortest time (C)</p> Signup and view all the answers

Which condition might require corticosteroids to be administered in large doses for a short duration?

<p>Allergic reactions (B)</p> Signup and view all the answers

Which of the following factors should be considered when determining the dosage of corticosteroids?

<p>Severity of the disorder (A)</p> Signup and view all the answers

Why is the frequency of administration particularly important for corticosteroids?

<p>Most adverse effects occur with long-term high doses (D)</p> Signup and view all the answers

Which characteristic of the patient must be evaluated when designing corticosteroid therapy?

<p>Expected adverse effects (C)</p> Signup and view all the answers

What is a significant advantage of parenteral administration of corticosteroids compared to oral administration?

<p>Faster onset of action (D)</p> Signup and view all the answers

What is an essential reason for tapering dosages of corticosteroids after initial high doses?

<p>To prevent withdrawal symptoms (B)</p> Signup and view all the answers

The goal of corticosteroid therapy is to avoid which of the following?

<p>Serious adverse reactions (C)</p> Signup and view all the answers

When tailoring corticosteroid therapy, which of the following is important to consider about the medication characteristics?

<p>The specific pharmacologic effects of the medication (A)</p> Signup and view all the answers

Which of the following disorders is NOT typically treated using exogenous corticosteroids?

<p>Infectious diseases (A)</p> Signup and view all the answers

How do exogenous corticosteroids primarily exert their effects at the cellular level?

<p>By binding to receptors and altering gene transcription (A)</p> Signup and view all the answers

How do exogenous corticosteroids influence the effects of different tissues?

<p>Their effects vary depending on the genetic makeup of the target tissue. (A)</p> Signup and view all the answers

Which of the following is NOT a potential indication for the use of exogenous corticosteroids?

<p>Treatment of bacterial infections (A)</p> Signup and view all the answers

What is a primary reason for the diversity of effects produced by exogenous corticosteroids?

<p>The wide variety of genes that can be influenced by corticosteroid binding (A)</p> Signup and view all the answers

Which of the following statements BEST describes the mechanism of action of exogenous corticosteroids?

<p>They bind to receptors and alter gene expression, influencing protein synthesis. (D)</p> Signup and view all the answers

What is the primary rationale for the use of exogenous corticosteroids in organ/tissue transplants and grafts?

<p>To suppress the immune system, reducing the risk of rejection (A)</p> Signup and view all the answers

Which of the following BEST describes the primary action of exogenous corticosteroids in the treatment of allergic reactions?

<p>Suppressing the inflammatory response triggered by allergens (D)</p> Signup and view all the answers

Flashcards

Pharmacology

The study of drugs and their effects on living organisms.

Pharmacotherapy

The use of drugs to prevent, diagnose, or treat medical conditions.

Medications

Drugs specifically used for therapeutic purposes.

Local Effects (of Medications)

Drugs that primarily affect the area where they are applied.

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Systemic Effects (of Medications)

Drugs that are absorbed into the bloodstream and act on distant sites.

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Drug Sources

The process of extracting drugs from natural sources, like plants, animals, or minerals.

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Drug Classifications

Organizing drugs into groups based on their effects, uses, or chemical properties.

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Drug Prototype

A representative drug from a specific drug class.

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Prototype drug

Drugs that represent a group of similar drugs. Often the first drug developed in its class. Examples: Morphine (opioid analgesics), Penicillin (beta-lactam antibiotics).

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Generic name

The official name of a drug, usually based on its chemical structure. It's independent of the brand.

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Brand name

The brand name of a drug, given by the manufacturer. It's protected by trademark.

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Over-the-counter drugs

Drugs that can be purchased without a prescription. They are regulated by legal standards.

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Prescription drugs

Drugs that require a prescription from a licensed healthcare professional.

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Food, Drug, and Cosmetic Act of 1938

A law that sets standards for purity and strength of official drugs.

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Controlled Substances Act

A law that classifies drugs according to their potential for abuse and medical use.

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Durham-Humphrey Amendment

A law that defines prescription drugs and over-the-counter drugs.

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Clinical Trials

The process of testing and evaluating a new drug before it can be marketed, involving four phases to assess safety, efficacy, and dosage.

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FDA Role

The U.S. Food and Drug Administration (FDA) is responsible for approving new drugs and overseeing their safety and effectiveness.

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Prescription to OTC

The FDA can change the status of a drug from prescription-only to over-the-counter (OTC), making it available without a doctor's prescription.

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Medication Administration Safety

A set of standards and guidelines designed to improve medication safety and reduce medication errors in healthcare settings.

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ISMP

The Institute for Safe Medication Practices (ISMP) advocates for safe medication practices, identifies potential drug hazards, and provides resources to healthcare professionals.

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Drug Information Sources

Reliable resources for drug information, including official compendia, journal articles, and reputable websites.

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American Hospital Formulary Service

A reference book used by pharmacists and healthcare professionals to provide comprehensive drug information, including dosages, interactions, and side effects.

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Effective Pharmacology Study

Strategies for studying pharmacology effectively, including concentrating on therapeutic classifications and prototypes, connecting new drugs to known similar ones, and focusing on key drug characteristics.

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Comprehensive Drug Abuse Prevention and Control Act

Enacted in 1970, this act governs the manufacturing and distribution of controlled substances, categorizing them based on their potential for abuse and therapeutic value.

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Drug Enforcement Administration (DEA)

The DEA enforces the Controlled Substances Act by registering individuals and companies legally permitted to handle controlled substances. They also monitor documentation and handling procedures to ensure compliance.

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FDA's CDER

The FDA's Center for Drug Evaluation and Research (CDER) is responsible for evaluating, approving, and monitoring drugs both for prescription and over-the-counter use. They also determine the necessity of clinical trials.

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U.S. Food and Drug Administration (FDA)

The U.S. Food and Drug Administration (FDA) ensures the safety and efficacy of prescription and non-prescription drugs through rigorous testing, approval processes, and ongoing monitoring.

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Clinical Trials (for new drugs)

This process involves testing a drug on people to evaluate its safety and efficacy. This process typically involves multiple phases and requires rigorous data collection and analysis.

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Drug Metabolism

The process by which drugs are changed within the body into a new form.

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Drug Excretion

The process of removing drugs and their byproducts from the body.

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Prodrug

An inactive form of a drug that becomes active after it's metabolized by the body.

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Enzyme Inducer

A substance that increases the activity of drug-metabolizing enzymes.

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Enzyme Inhibitor

A substance that slows down the activity of drug-metabolizing enzymes.

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Drug Distribution

The transport of drug molecules within the body.

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Drug Absorption

The movement of a drug from the site of administration into the bloodstream.

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Organs of Excretion

The process of removing drugs and their byproducts through the kidneys, intestines, lungs, and skin.

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Pharmacokinetics

The study of how drugs move through the body, including absorption, distribution, metabolism, and excretion.

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Onset of Drug Action

The rate of absorption affects how quickly a drug starts working.

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Protein Binding

The extent to which a drug binds to proteins in the blood.

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Blood-Brain Barrier

A barrier that protects the brain from harmful substances, affecting how easily drugs can enter.

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Cells as factories

Cells are like tiny factories performing various essential functions within the body.

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Basic functions of cells

Cells are the basic unit of life and perform many functions.

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Common characteristics of cells

All cells share common characteristics despite differences in their specialization.

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Key cellular functions

Cells can exchange materials with their surroundings, obtain energy from food, reproduce, and communicate with other cells.

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Drug action on cell membranes

Drugs must reach and interact with cell membranes to exert their effects.

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Drug transport through the body

Drugs move through the body using various transport pathways and mechanisms.

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Systemic drug effects

Most drugs are administered for systemic effects, meaning they act on multiple areas in the body.

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Cell membrane as a barrier

The cell membrane acts as a barrier and controls the passage of substances in and out of the cell.

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Drug Overdose

A condition resulting from excessive intake of a drug, potentially causing harm to the body.

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Overdose: Single Dose vs. Prolonged Use

Overdose can occur from a single large dose or prolonged use of smaller doses.

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Overdose and Types of Drugs

Overdose can involve any type of drug, including alcohol, prescription medicines, over-the-counter medications, and illicit substances.

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Overdose as a Medical Emergency

Overdose is a medical emergency regardless of the location. Prompt medical attention is crucial.

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Overdose Treatment Goals

Treating overdose focuses on early intervention, stabilizing vital functions, preventing further damage by reducing absorption, increasing elimination, and administering antidotes when possible.

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Drug-Related Variables

Factors related to the medication itself that can influence its effects, including the route of administration, dosage, and potential interactions with other medications or foods.

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Synergism

When two drugs are used together, their combined effect is greater than the sum of their individual effects.

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Drug Interactions that Decrease Effects

Interactions that decrease the desired effect of a drug, either by directly counteracting it or by reducing its absorption or metabolism.

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Pharmacogenomics

The study of how genetic makeup can influence drug responses, including metabolism, efficacy, and adverse effects.

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Adverse Drug Effects

Unwanted effects of a drug that occur when it is used at usual therapeutic doses.

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Tolerance

A reduced response to a drug over time, requiring higher doses to achieve the same effect.

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Cross-Tolerance

When tolerance to one drug leads to tolerance to another drug with similar effects.

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Patient-Related Variables

Factors related to the patient that can influence drug responses, including age, body weight, genetics, and existing health conditions.

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Serum Drug Level

Laboratory measurement of the amount of drug in the blood at a specific time.

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Minimum Effective Concentration (MEC)

The lowest concentration of a drug that produces a therapeutic effect.

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Toxic Concentration

An excessive level of medication in the bloodstream, potentially leading to toxicity.

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Receptor Theory of Drug Action

Drugs exert their effects by binding to specific cells called receptors.

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Agonist Drugs

Drugs that activate or enhance the effects of a receptor.

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Antagonist Drugs

Drugs that block or inhibit the effects of a receptor.

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Nonreceptor Drug Actions

Drugs that do not work by binding to receptors.

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Examples of Nonreceptor Drug Actions

Examples of drugs that do not work by binding to receptors.

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Unit Dose System

A medication administration system where individual doses are packaged and labeled for each patient, reducing medication errors and improving safety.

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Computerized, Locked Cabinets

Secure drug storage cabinets that use electronic access control and tracking to monitor medication use and prevent unauthorized access.

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CPOE

Computerized Physician Order Entry (CPOE) is a system that allows healthcare professionals to electronically enter medication orders, reducing handwritten errors and improving communication.

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Point of Care Medication Administration

A medication administration method where medications are given at the patient's bedside, often using bar coding to ensure accuracy and patient safety.

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Medication Reconciliation

A comprehensive process of comparing a patient's current medication list with previous lists to identify any discrepancies or potential inconsistencies.

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Medication Orders

Written instructions for medications, outlining the patient's full name, medication name (preferably using generic name), dosage, route, frequency of administration, and the date and time of the order.

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Medication Order Transcription

Preferably typed into a computer to reduce transcription errors and ensure accuracy.

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Medication Order Transcription (definition)

The process of carefully and accurately writing down or entering medication orders to avoid any mistakes.

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Controlled Release Medication Systems

Medication delivery systems designed to release the drug slowly, like tablets or capsules, to maintain consistent levels over a longer period. Prevents frequent dosage and ensures sustained effects.

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Transdermal Drug Delivery

A system of delivering medication directly through the skin for systemic absorption, often using patches or pumps. It bypasses the digestive system.

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Topical Medication Delivery

Medication delivery systems intended for local effects specific to the area applied, such as solutions, creams, and suppositories. They primarily target the application site.

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Calculating Medication Dosages

The process of calculating dosage based on the desired amount of medication considering the available strength, volume, and unit of measurement. It's important for administering the right dose.

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Dosage Calculation Formula: D X H = V

A formula used for calculating medication dosages. Variables include the desired dose, the available dose, the unknown quantity, and the unit or volume of the medication.

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Parenteral Route

Administrating medication through injection into a blood vessel, muscle, or spinal column. This bypasses the digestive system for faster and direct action.

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Topical Route

Administrating medication directly to the skin or mucous membrane, for localized effects.

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Vials

Single or multiple dose containers for injectable medications, often made of glass and sealed with a rubber stopper.

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Ampules

Glass containers for injectable medications designed to be broken open to draw out the medication.

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Prefilled Syringes

Syringes with pre-measured medication and needles attached, ready for administration.

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Needle Gauge

The size of the needle's lumen (internal opening), measured in gauges. A higher number indicates a smaller lumen.

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Needle Length

The length of the needle, chosen based on the injection route, medication's viscosity, and patient's size.

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Sterility in Injections

Maintaining sterility during the preparation, packaging, and administration of medications for injection is crucial to prevent infection.

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Needleless Systems

Needleless systems aim to prevent accidental needlestick injuries and reduce the spread of infections by reducing the use of needles.

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Syringes

Syringes are made of disposable plastic, precisely calibrated to measure medication doses. Different types cater to varied needs.

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Subcutaneous Injections

Subcutaneous injections are administered into the fatty layer beneath the skin. Common areas include the upper arms, abdomen, back, and thighs.

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Intramuscular Injections

Intramuscular injections are administered into muscles. The deltoid, ventrogluteal, and vastus lateralis are common muscle injection sites.

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Intravenous Injections

Intravenous injections are administered directly into a vein. Common injection sites include the back of the hands and forearms.

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Intradermal Injections

Intradermal injections are administered into the upper layers of the skin. This is used for skin tests like TB tests.

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Intra-arterial Injections

Intra-arterial injections are administered directly into an artery, typically used when an arterial line is present for monitoring.

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Intrathecal Injections

Intrathecal injections are administered into the cerebrospinal fluid, often used for medication delivery to the brain or spinal cord. They require expert administration.

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Nondrug Interventions

Interventions that focus on promoting health and well-being through non-drug approaches. Examples include optimizing nutrition, hydration, exercise, rest, sleep, hand hygiene, and infection prevention.

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Drug Therapy Evaluation Criteria

Evaluating a patient's response to drug therapy includes monitoring for symptom relief, accurate medication administration, minimizing adverse effects, ensuring patient adherence, and measuring specific parameters to assess drug effectiveness.

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Drug Therapy Outcomes Timeframe

Drug therapy outcomes usually take hours or days to assess; they are rarely immediate.

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Examples of Nondrug Interventions

Hand hygiene, ambulation, positioning, exercise, deep breathing, heat or cold therapy, sleep scheduling, and vital sign monitoring are all examples of non-drug nursing interventions.

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Drug Therapy Goals Focus

Goals of drug therapy should be stated in terms of the patient's behavior and changes.

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Importance of Nondrug Interventions

Nondrug interventions, such as appropriate nutrition, hydration, and exercise, can be vital for improving patient health and reducing the need for medications.

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Promoting Rest and Sleep

Promoting rest and sleep is crucial for recovering patients. Nursing interventions can include scheduling quiet times, creating a calm environment, and addressing factors that may interfere with sleep.

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Monitoring Vital Signs and Data

Monitoring and recording vital signs, intake and output, and other relevant data helps determine the effectiveness of drug therapy and detect potential problems.

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Nursing Process in Drug Therapy

A systematic approach to patient care that involves assessment, diagnosis, planning, intervention, and evaluation. It helps ensure proper medication use and individualized care.

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Assessment in Medication History

Collecting information about a patient's medication history, allergies, current medications, and any conditions that might affect drug therapy.

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Medication History Questions

Questions asked to gather information about a patient's medication history, including allergies, current medications, ability to swallow, and general health conditions.

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General Nondrug Interventions

Interventions focusing on promoting health, preventing unnecessary drug therapy, using nondrug measures to enhance drug effects, and educating patients.

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Nursing Diagnosis in Drug Therapy

The phase in the nursing process where the nurse identifies a patient's healthcare needs related to medication use, such as the risk of adverse effects or adherence issues.

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Planning in Drug Therapy

The phase in the nursing process where the nurse creates a plan of care for the patient that addresses identified medication-related needs.

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Interventions in Drug Therapy

Actions taken by the nurse to address the patient's medication-related needs, including administering drugs, observing responses, and educating patients.

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Evaluation in Drug Therapy

The phase in the nursing process where the nurse evaluates the effectiveness of the medication plan and makes adjustments as needed.

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What are antimicrobial medications used for?

Antimicrobial medications are used to treat or prevent infections caused by bacteria, fungi, viruses, and parasites. They are necessary when the body's natural defenses are weak against infection.

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How do microorganisms cause infections?

Microorganisms (like bacteria) can attach to cells, invade tissue, multiply, and cause infection.

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What is normal microbial flora?

Normal microbial flora are microorganisms that live on the skin, in the upper respiratory tract, and in the colon. They usually protect the body from harmful infections.

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When can normal microbial flora cause disease?

Normal microbial flora can cause disease in certain conditions, such as when older adults, debilitated, or immunosuppressed patients are weakened, allowing the flora to overgrow.

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How can antimicrobial medications affect normal flora?

Antimicrobial medications can suppress normal flora, which can allow potentially harmful microorganisms to thrive.

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How do microorganisms adapt to avoid being destroyed?

Microorganisms adapt to protect themselves from host defense mechanisms and antimicrobials.

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What are the major classifications of microorganisms?

Bacteria, viruses, fungi, and parasites are the major classifications of microorganisms.

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Are antimicrobial medications effective against all microorganisms?

Antimicrobial medications are NOT effective against all microorganisms. They target specific pathogens like bacteria, fungi, or viruses.

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Opportunistic Infections

Infections caused by microbes that are usually harmless but can cause illness in people with weakened immune systems.

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Who is vulnerable to opportunistic infections?

These infections are more likely to occur in patients with compromised immune systems, such as those with severe burns, cancer, HIV infection, or those receiving immunosuppressive therapy.

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Gram Stain

A laboratory test that identifies bacteria based on their microscopic appearance.

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Culture (in lab identification)

Growing microbes in a laboratory to identify the specific type.

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Opportunistic Pathogens

A pathogen that is normally found in the body or environment but can cause disease under certain conditions.

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Infectious Diseases

Infections where the pathogen alone is enough to cause disease in any individual.

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How are infectious diseases spread?

These are infections that can be spread through direct contact with an infected person, contaminated hands, food, water or objects.

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What does the Gram Stain test reveal?

This is a method of identifying pathogens in the laboratory by using a colored dye to stain the bacteria, allowing them to be seen under a microscope. Staining helps classify bacteria into two main groups: gram-positive and gram-negative, based on their cell wall characteristics.

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PCR (Polymerase Chain Reaction)

Laboratory tests that identify the presence of microbial DNA in a sample.

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Antibiotic-Resistant Microorganisms

Infections caused by pathogens that no longer respond to commonly used antibiotics.

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How Antibiotic Resistance Develops (1)

Resistant microorganisms thrive when susceptible organisms, including normal flora, are suppressed by antimicrobials.

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How Antibiotic Resistance Develops (2)

Resistant microorganisms can emerge during or after antimicrobial therapy, especially in individuals with compromised immune systems.

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How Antibiotic Resistance Develops (3)

Broad-spectrum antibiotics can suppress normal flora, creating an opportunity for resistant strains to dominate.

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How Antibiotic Resistance Develops (4)

Incomplete or inadequate antimicrobial treatment can lead to the development of antibiotic resistance.

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Antibiotic Resistance in Respiratory Infections

Lower respiratory tract infections are often associated with high rates of antimicrobial resistance.

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Identifying Pathogens and Resistance

Laboratory tests like serology and PCR are crucial for identifying infectious agents and detecting antibiotic resistance.

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Bactericidal drugs

Drugs that kill bacteria.

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Bacteriostatic drugs

Drugs that slow or stop the growth of bacteria.

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Broad-spectrum antibiotics

Antibiotics that are effective against a wide range of bacteria.

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Narrow-spectrum antibiotics

Antibiotics that are effective against a narrow range of bacteria.

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How important are antibiotics?

These drugs are important for controlling bacterial infections. They are often used to fight resistant bacteria.

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What can happen if antibiotics are overused?

Overuse, misuse, and abuse of antibiotics can lead to drug resistance.

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What is pharmacotherapy?

The use of medications to prevent, treat, or diagnose medical conditions.

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What is pharmacokinetics?

The study of how drugs move through the body. This includes absorption, distribution, metabolism, and excretion.

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What types of infections are difficult to treat?

Infections that are difficult to treat because they tend to reoccur, involve multiple organisms, and often show high antibiotic resistance.

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What is microbial resistance?

The ability of microbes to resist the effects of medications, like antibiotics.

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How do microbes become resistant?

Mechanisms include producing enzymes to inactivate medications, modifying the target sites for the antibiotics, producing alternative enzymes to bypass antibiotics, changing cell wall permeability, increasing their ability to pump medications out of the cell, and modifying antibiotic binding targets.

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What are host defense mechanisms?

Strategies that help the body defend against infections.

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What are some examples of host defense mechanisms?

Examples include intact skin, mucous membranes, anti-infective secretions, mechanical movement like coughing and swallowing, phagocytic cells, and immune and inflammatory processes.

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What are host defense impairments?

Factors that weaken the body's defenses, making it more susceptible to infections.

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What are some examples of host defense impairments?

Breaks in skin and mucous membranes due to trauma, inflammation, open lesions, or medical procedures, impaired blood supply due to conditions like neutropenia, and malnutrition.

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What are some other examples of host defense impairments?

Poor personal hygiene, suppression of normal flora due to antibiotics, suppression of immune system and inflammatory response, and diabetes or other chronic diseases.

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Cost-Effective Antimicrobial Therapy

Using older, less expensive drugs when they meet the criteria for treatment.

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Combination Antimicrobial Therapy

Combining multiple antimicrobials to treat infections caused by several microbes, hospital-acquired infections, or severe infections.

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Antimicrobial Therapy Routes

Choosing the route of administration (oral or IV) for systemic infections based on the patient's condition, infection's location and severity, ability to take oral medications, and available dosage forms.

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Antibiotic Duration of Therapy

The length of time to administer antibiotics, varying depending on the reason for use. Single dose for prophylaxis, 7-10 days or until the patient recovers for acute infections.

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Antibiotics Use in Special Populations

Considering special populations like children, older adults, those with kidney or liver problems, critically ill individuals and people receiving home care when prescribing antimicrobials.

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Community-Acquired Infection

Contracted outside of a healthcare facility, such as in the community.

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Hospital-Acquired Infection

Acquired within a healthcare setting, often more severe and harder to manage due to drug-resistance and immunocompromised patients.

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Antimicrobial Therapy

Antimicrobials are crucial for treating bacterial infections, but they can be misused, leading to resistance and side effects.

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Prostaglandins

Chemical messengers produced in most body tissues that regulate various functions and are involved in inflammation.

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NSAIDs

Drugs that decrease pain, fever, and inflammation by inhibiting the production of prostaglandins.

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COX (Cyclooxygenase)

A key enzyme required for the production of prostaglandins.

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Hypothalamus

The part of the brain that controls body temperature.

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How NSAIDs reduce fever

The effect of NSAIDs on fever occurs by reducing the hypothalamic response and lowering the 'thermostat' setting.

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How NSAIDs reduce pain

The mechanism of action of NSAIDs in reducing pain involves blocking pain impulses centrally and peripherally.

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Acetaminophen vs. NSAIDs

Acetaminophen (Tylenol) lacks anti-inflammatory properties and does not inhibit platelet aggregation.

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NSAIDs' anti-platelet effect

Aspirin and some NSAIDs have an effect on platelets, reducing their ability to aggregate and clot.

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Why are NSAIDs contraindicated during pregnancy?

NSAIDs are not recommended during pregnancy due to potential risks to the fetus, including low birth weight, kidney toxicity, premature closure of the ductus arteriosus, intracranial hemorrhage, and stillbirth.

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What causes Gout?

Gout is caused by either producing too much uric acid or the inability to excrete it properly.

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How does colchicine work?

Colchicine is a mitotic agent used to treat and prevent gout. It helps to prevent inflammation by limiting the movement of white blood cells to the area where urate crystals have accumulated.

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What does allopurinol do?

Allopurinol is a uricosuric agent that helps to lower the levels of uric acid in the blood.

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What triggers Gout pain?

Urate crystals are what trigger the pain and inflammation associated with Gout. These crystals form when there is too much uric acid in the body.

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NSAIDs for Pain Relief

Pain relievers like ibuprofen and naproxen are effective for managing mild to moderate pain, including headaches, minor injuries, and some surgeries, but are not recommended for deeper, internal pain.

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Acetaminophen: Pain and Fever Relief

Acetaminophen is a commonly used drug for mild to moderate pain and fever reduction. It's generally safe and effective when used as directed.

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Aspirin for Heart Health

Low-dose aspirin is often prescribed to people who have had strokes, mini-strokes, or heart problems to prevent future complications.

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NSAIDs and Stomach Risks

NSAIDs can cause serious stomach ulcers, bleeding, or even perforation of the gut. They are not suitable for people with pre-existing stomach problems or bleeding disorders.

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Alcohol and NSAID Risks

Chronic alcohol drinkers should avoid NSAIDs as they can increase the risk of stomach damage and bleeding.

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Aspirin: Not for Kids

Children and teenagers should not take aspirin as it's linked to Reye syndrome, a rare but serious condition that affects the liver and brain.

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NSAID Allergies

NSAIDs can cause allergic reactions. This is especially true for people who have had a serious reaction to aspirin.

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NSAIDs and Kidney Function

NSAIDs are generally safe for people with normal kidney function. However, those with reduced kidney function should use them with caution and under medical supervision.

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Acetaminophen Poisoning

Acetaminophen poisoning can happen from taking a single large dose or by repeatedly taking too much over time.

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Ibuprofen

Ibuprofen is a type of NSAID that belongs to the propionic acid derivatives. It stops inflammation signals in both the brain and the body.

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Meloxicam

Meloxicam is an oxicam derivative NSAID that works similarly to ibuprofen. It is known for its strong anti-inflammatory properties.

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Indomethacin

Indomethacin is another NSAID that belongs to the acetic acid derivatives. It is known for being very effective, but it has more side effects.

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Celecoxib

Celecoxib is a selective COX-2 inhibitor. This means it targets a specific enzyme involved in inflammation and pain.

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NSAID Uses

NSAIDs are used in various situations to treat pain and inflammation. Degenerative conditions like osteoarthritis and rheumatoid arthritis are common examples.

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Acetaminophen (Pain Relief)

Acetaminophen can be used to reduce pain but it does not have the same anti-inflammatory effects as NSAIDs.

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Aspirin's actions

Aspirin works by reducing fever by acting on the hypothalamus, decreasing inflammation, and inhibiting platelet aggregation.

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Acetaminophen's key properties

Acetaminophen is an effective pain reliever and fever reducer, similar to aspirin, but it does not have anti-inflammatory properties.

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Acetaminophen's potential toxicity

Acetaminophen's metabolism in the liver generates a toxic metabolite, and excessive doses can lead to liver damage or even death.

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Acetaminophen overdose effects

Overdose of acetaminophen can cause liver damage. Signs include elevated liver enzymes, jaundice, vomiting, and CNS changes leading to coma.

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Acetaminophen overdose treatment

Gastric lavage and activated charcoal are interventions for acetaminophen overdose, but the antidote is acetylcysteine, most effective within 8 hours.

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Salicylates and pain blocking

Salicylates block pain signals centrally and peripherally. Aspirin is a salicylate.

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Low-dose aspirin for heart conditions

Low-dose aspirin is used to manage heart conditions like ischemic stroke, transient ischemic attack, angina, and acute myocardial infarction.

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Acetaminophen's available forms

Acetaminophen is available in tablets, liquids, and rectal suppositories, making it versatile for different patient needs.

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Corticosteroids

Hormones produced by the adrenal cortex that affect almost all body organs and are crucial for maintaining homeostasis.

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Glucocorticoids

A type of steroid hormone produced by the adrenal glands, primarily affecting metabolism, inflammation, and immune responses.

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Mineralocorticoids

A type of steroid hormone produced by the adrenal glands, primarily involved in maintaining salt and water balance in the body.

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Endogenous Corticosteroids

Corticosteroids produced by the body.

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Adrenal Sex Hormones

Steroid hormones produced by the adrenal glands, including male sex hormones like testosterone and female sex hormones like estrogen and progesterone.

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Exogenous Corticosteroids

Corticosteroids taken as medication.

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Corticosteroid Secretion System

The system that regulates the release of corticosteroids, involving the hypothalamus, anterior pituitary, and adrenal cortex.

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Aldosterone

The main mineralocorticoid, produced by the adrenal glands, playing a crucial role in regulating electrolyte balance, particularly sodium and potassium.

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Corticosteroids

A group of steroid hormones produced by the adrenal glands, including glucocorticoids, mineralocorticoids, and adrenal sex hormones.

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Glucocorticoids

A type of corticosteroid that primarily regulates blood sugar levels and has anti-inflammatory effects.

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Mineralocorticoids

A type of corticosteroid that primarily regulates electrolyte balance and blood pressure.

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Cortisol

The primary glucocorticoid produced by the adrenal glands, playing a vital role in regulating metabolism, inflammation, and immune responses.

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Cyclic Secretion of Corticosteroids

The rhythmic pattern of hormone secretion, particularly cortisol, with the highest levels occurring upon waking and the lowest levels before sleep.

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Adrenal Sex Hormones

Hormones produced by the adrenal cortex that have a similar structure to sex hormones but are produced in smaller amounts.

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Masculinizing Effect

A masculinizing effect caused by excessive production of androgens, the male sex hormones.

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Negative Feedback System

The process by which the body regulates the production of corticosteroids based on the body's needs, ensuring that there is just the right amount.

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What are corticosteroids?

Corticosteroids are medications used for their anti-inflammatory, immunosuppressive, anti-allergic, and anti-stress properties.

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What's the main goal of corticosteroid therapy?

The goal of corticosteroid therapy is to reduce symptoms to a tolerable level while avoiding serious side effects.

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What factors impact the choice of a corticosteroid?

When choosing a corticosteroid, factors like the reason for using it, desired route of administration, patient's characteristics, and potential side effects are important considerations.

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How is corticosteroid dosage determined?

The dosage of corticosteroids should be individualized based on the severity of the condition, whether it's acute or chronic, and the patient's response to treatment.

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What's the general principle for corticosteroid dosage?

The general principle for corticosteroid dosage is to use the smallest effective dose for the shortest possible time.

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Is corticosteroid therapy curative?

Corticosteroid therapy is palliative, meaning it aims to relieve symptoms but doesn't cure the condition.

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Local Corticosteroid Administration

Administering corticosteroids locally reduces the chances of systemic side effects, like suppressing the body's natural hormone production.

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Preferred Route for Corticosteroids

Oral administration is generally preferred for corticosteroids due to its ease of use and convenience.

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Major Adverse Effect of Long-Term Corticosteroid Use

High doses of corticosteroids over long periods can suppress the body's natural hormone production, leading to adrenocortical insufficiency.

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Corticosteroid Dosage for Acute Situations

Acute situations often require large doses of corticosteroids initially, followed by a gradual reduction.

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Scheduling Corticosteroids

Corticosteroid scheduling is more critical than for many other medications due to the possibility of systemic effects and hormone suppression.

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Conditions Managed with Corticosteroids

Corticosteroids are useful for managing allergic reactions, inflammatory skin conditions like contact dermatitis, chronic condition flare-ups, and post-surgery inflammation.

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Choosing Corticosteroid Administration

When choosing between local and systemic corticosteroid administration, local is preferable for preventing systemic side effects.

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Routes for Corticosteroid Administration

The most common route for administering corticosteroids is oral, but parenteral (IM or IV) routes may sometimes be used.

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What are exogenous corticosteroids?

Exogenous corticosteroids, also known as steroids, are synthetic hormones that mimic the actions of natural corticosteroids produced by the adrenal glands. They are used to treat a wide range of inflammatory and autoimmune conditions.

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How do exogenous corticosteroids work?

Exogenous corticosteroids are highly effective in treating various inflammatory conditions like asthma, allergies, and inflammatory bowel disease, as they suppress the immune system and reduce inflammation.

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Why are exogenous corticosteroids contraindicated in systemic fungal infections?

Exogenous corticosteroids may worsen fungal infections because they suppress the immune system, making the body more vulnerable to infections. This suppression makes it difficult for the body to fight off fungal infections.

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How are exogenous corticosteroids dosed?

Exogenous corticosteroids are given in two main ways: replacement doses to correct a deficiency and therapeutic doses to exert specific effects beyond normal physiologic levels.

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What are important considerations for patients taking exogenous corticosteroids?

When using exogenous corticosteroids, it's crucial to monitor patients for potential side effects. This includes monitoring blood sugar levels, blood pressure, and signs of infection, as corticosteroids can cause or worsen these conditions.

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Who needs to be cautious when using exogenous corticosteroids?

Patients using exogenous corticosteroids need to use them with caution if they have a history of infections, diabetes, peptic ulcer disease, or heart failure, as corticosteroids can worsen these conditions.

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What's a critical aspect of stopping exogenous corticosteroids?

Patients using exogenous corticosteroids should avoid abrupt withdrawal, as it can lead to adrenal insufficiency. A gradual tapering of the dose is recommended to allow the adrenal glands to start producing their own hormones again.

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What are important long-term considerations for exogenous corticosteroid use?

Exogenous corticosteroids are not a long-term solution for chronic conditions. Long-term use can lead to serious side effects like osteoporosis, diabetes, and Cushing's syndrome.

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Study Notes

Introduction to Pharmacology

  • Pharmacology is the study of drugs that alter functions of living organisms
  • Pharmacotherapy is the use of drugs to prevent, diagnose, or treat signs, symptoms, and disease processes
  • Medications are drugs given for therapeutic purposes

Effects of Medications

  • Local effects act primarily at the site of application
  • Systemic effects are taken into the body, circulated through the bloodstream to sites of action, and eliminated from the body

Drug Sources

  • Drugs come from plants, animals, minerals, and synthetic compounds

Drug Classifications and Prototypes

  • Drugs are classified by their effects on particular body systems, therapeutic uses, and chemical characteristics
  • Prototypes are individual drugs that represent groups of drugs, often the first of a particular group developed
    • Examples: Morphine (opioid analgesics), Penicillin (beta-lactam antibacterial drugs)

Drug Names

  • Drugs have generic (chemical or official) names and brand (trade) names
  • Using both names can cause confusion

Over-the-Counter Medications

  • Over-the-counter medications are legally regulated

Prescription and Nonprescription Drugs

  • Prescription medications require a healthcare professional's written order
  • Nonprescription medications (over-the-counter) do not require a prescription but are still regulated by law

FDA and Drug Approval

  • FDA's Center for Drug Evaluation and Research (CDER) approves new prescription drugs yearly
  • CDER approves OTC drugs (over-the-counter)
  • CDER determines the need for clinical trials
  • The FDA is responsible for ensuring drug safety and efficacy before they can be marketed and it requires specific testing standards (Phases 1-4)

Safety in Drug Administration

  • Quality and Safety Education for Nurses (QSEN)
  • National Patient Safety Goals
  • The Institute for Safe Medication Practices (ISMP)
  • Rights off Medication Administration
  • "Do Not Use" list of unacceptable abbreviations
  • Targeted High-Risk Activities
  • High-Alert Medications
  • Pregnancy Categories for Safety
  • Beers Criteria

Sources and Authoritative Sources of Drug Information

  • Pharmacology textbooks, drug reference books, journal articles, and the internet
  • More authoritative resources such as the American Hospital Formulary Service and less authoritative resources such as the Physicians' Desk Reference (PDR)

Study Strategies for Pharmacology

  • Concentrate on therapeutic classifications and prototypes
  • Connect new drug information to known similar drugs or prototypes
  • Focus on drugs' main characteristics
  • Use your own words when taking notes

Comprehensive Drug Abuse Prevention and Control Act

  • Passed in 1970
  • Title II: Controlled Substances Act
    • Regulates manufacturing and distribution of
      • Narcotics
      • Depressants
      • Stimulants
      • Hallucinogens
      • Anabolic steroids
  • Also includes categories (schedules) I-V for controlled substances to categorize drugs based on potential for abuse and/or medical use

Drug Enforcement Administration (DEA)

  • Enforces the Controlled Substances Act
  • Registers individuals and companies legally allowed to handle controlled substances
  • Regulates documentation and handling of controlled substances

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Test your knowledge of pharmacology with this quiz covering drug effects, sources, classifications, and names. Understand the difference between local and systemic effects, as well as the significance of prototypes in drug therapy. Perfect for students and professionals in the health sciences.

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