Introduction to Pathology Lecture 4

<p>Granulation tissue fills the incision space (B)</p> Signup and view all the answers

<p>Formation of a large scar (D)</p> Signup and view all the answers

<p>High vascularity (B)</p> Signup and view all the answers

<p>Two weeks (C)</p> Signup and view all the answers

<p>Complete resolution of all inflammation (A)</p> Signup and view all the answers

<p>To remove necrotic tissue and debris (C)</p> Signup and view all the answers

<p>To produce new blood vessels and support cell proliferation (A)</p> Signup and view all the answers

<p>Granulation tissue formation (D)</p> Signup and view all the answers

<p>Osteoblasts (C)</p> Signup and view all the answers

<p>Lamellar bone (A)</p> Signup and view all the answers

<p>It changes consistency depending on the tissue type (C)</p> Signup and view all the answers

<p>Stage 1 (C)</p> Signup and view all the answers

<p>To lay down osteoid that calcifies to form bone (B)</p> Signup and view all the answers

<p>They contribute to collagen production and matrix deposition. (D)</p> Signup and view all the answers

<p>They are responsible for blood supply distribution (B)</p> Signup and view all the answers

<p>Reduction of wound surface area and closing the gap between dermal edges. (C)</p> Signup and view all the answers

<p>The bone regains a structure comparable to the original (C)</p> Signup and view all the answers

<p>Increased vascularity (B)</p> Signup and view all the answers

<p>Osteoclasts (A)</p> Signup and view all the answers

<p>Accumulation of polymorphonuclear leukocytes at the injury site (C)</p> Signup and view all the answers

Macrophages clear debris, fibrin, red blood cells, and inflammatory exudate from the clot during fracture healing.

Capillary loops and mesenchymal cells from periosteum/endosteum grow into the fracture site, forming granulation tissue with osteogenic potential.

The material uniting fracture ends; can be soft (granulation tissue) or hard (bone/cartilage).

Mesenchymal cells differentiate into osteoblasts, forming woven bone or cartilage—the initial framework of the fracture healing.

Osteoblasts lay down osteoid, which calcifies into orderly, lamellar bone (concentrically arranged around blood vessels).

Concentric bony lamellae around blood vessels in the newly formed bone, a normal bone structure.

Osteoclasts remove and osteoblasts build new bone, leading to nearly original tissue structure.

Parts of the callus that are gradually broken down and replaced with new tissue during bone remodeling, progressing to either compact or cancellous bone.

Macrophages replace neutrophils in tissue repair, removing debris, fibrin, and foreign material. They also promote new blood vessel growth and tissue formation.

Scar formation involves collagen buildup and blood vessel reduction, changing granulation tissue into a pale, avascular scar composed of fibroblasts and collagen.

Wound contraction is a process that closes large wounds by decreasing the gap between edges and reducing surface area.

Unlike skin wounds, fractures heal by forming specialized bone tissue, rather than fibrous scar tissue.

Bone is composed of calcified osteoid tissue, which contains collagen fibers in a mucoprotein matrix.

Woven bone is an immature type of bone with an irregular arrangement of collagen bundles and fewer calcium and osteocytes.

Lamellar bone is a mature type of bone with collagen bundles arranged in parallel sheets.

Immediately after a fracture, bleeding from torn blood vessels creates a hematoma. If this hematomaossifies, myositis ossificans results.

Surgical wounds heal quickly and cleanly when tissues are precisely rejoined.

Cells that contract to close wounds, but if prevented can cause large scars.

A type of wound healing where the edges of a wound are brought together.

The new tissue that fills a wound, containing blood vessels and collagen.

Immune cells that are first to respond to an injury, like a wound.

Protein fibers that strengthen and support the wound.

Wounds heal slowly, with more scar tissue, as edges are not close together.

Immune cells that replace neutrophils in wound healing.