Introduction to Neurons and Neuroscience
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Questions and Answers

Which of the following accurately describes the relationship between the Neuron Doctrine and the Law of Dynamic Polarization?

  • The Neuron Doctrine explains how neurons communicate, while the Law of Dynamic Polarization explains how neurons are structured.
  • The Neuron Doctrine states that neurons are the basic unit of the nervous system, while the Law of Dynamic Polarization describes the direction of information flow within a neuron. (correct)
  • The Neuron Doctrine and the Law of Dynamic Polarization are unrelated concepts, each addressing different aspects of neuron function.
  • The Neuron Doctrine and the Law of Dynamic Polarization are essentially the same concept, both describing the unidirectional flow of information within a neuron.
  • What is the defining characteristic that distinguishes interneurons from sensory or motor neurons?

  • Interneurons primarily transmit signals within the central nervous system, while sensory and motor neurons transmit signals to and from the central nervous system. (correct)
  • Interneurons are responsible for processing information, while sensory and motor neurons are responsible for receiving and sending information.
  • Interneurons have a smaller cell body than sensory or motor neurons.
  • Interneurons only communicate with other interneurons, while sensory and motor neurons communicate with both interneurons and other neurons.
  • Which of the following is NOT a key component of the cytoskeleton?

  • Microtubules
  • Microfilaments
  • Intermediate filaments
  • Phospholipids (correct)
  • What type of transport mechanism requires energy to move substances across the plasma membrane?

    <p>Active transport (D)</p> Signup and view all the answers

    How does increasing the conductance (number of open channels) for potassium ions (K+) impact the resting membrane potential (Vm)?

    <p>Decreases Vm, making the cell more negative (D)</p> Signup and view all the answers

    What is the primary mechanism by which calcium channel blockers treat multiple sclerosis (MS)?

    <p>They slow down the conduction of action potentials, reducing the spread of the disease. (C)</p> Signup and view all the answers

    In the context of synaptic transmission, which of the following best describes the role of the SNARE complex?

    <p>It mediates the fusion of synaptic vesicles with the presynaptic membrane, promoting neurotransmitter release. (B)</p> Signup and view all the answers

    How does the action of botulinum toxin (BoTox) at the neuromuscular junction (NMJ) differ from myasthenia gravis?

    <p>BoTox blocks the release of acetylcholine, while myasthenia gravis causes the degradation of acetylcholine receptors. (B)</p> Signup and view all the answers

    Which of the following factors contributes to the 'all-or-none' nature of an action potential (AP)?

    <p>The initial stimulus must always exceed a certain threshold for the AP to occur. (C)</p> Signup and view all the answers

    How can the same neurotransmitter have both excitatory and inhibitory effects?

    <p>The transmitter molecule binds to different receptor subtypes, causing varied downstream effects. (D)</p> Signup and view all the answers

    What is the primary role of the amygdala in memory formation?

    <p>It regulates the emotional significance of memories. (D)</p> Signup and view all the answers

    Which type of memory is primarily associated with the striatum of the basal ganglia?

    <p>Procedural memory (B)</p> Signup and view all the answers

    What is the primary difference between AMPA and NMDA receptors in terms of their activation?

    <p>AMPA receptors are permeable to sodium ions, while NMDA receptors are permeable to both sodium and calcium ions. (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of long-term potentiation (LTP)?

    <p>It is a long-lasting decrease in synaptic efficacy. (C)</p> Signup and view all the answers

    Which of the following statements BEST describes the relationship between the hippocampus and the basal ganglia in memory formation?

    <p>The hippocampus is primarily involved with declarative memories, especially spatial information, while the basal ganglia play a crucial role in procedural memory formation. (B)</p> Signup and view all the answers

    What is the primary difference between anterograde and retrograde amnesia?

    <p>Anterograde amnesia is an inability to form new memories, while retrograde amnesia is a loss of memories from the past. (B)</p> Signup and view all the answers

    Which type of memory is MOST susceptible to disruption by a blow to the head?

    <p>Short-term memory (A)</p> Signup and view all the answers

    Which brain structure is MOST likely to be damaged in individuals with Korsakoff's syndrome?

    <p>Thalamus (B)</p> Signup and view all the answers

    Flashcards

    Neuron Structure

    Neurons consist of axons, dendrites, soma, and synaptic terminals.

    Axon vs Dendrite

    Axons transmit signals away from the neuron, while dendrites receive signals from other neurons.

    Presynaptic vs Postsynaptic Neuron

    Presynaptic neurons send signals, while postsynaptic neurons receive them at the synapse.

    Law of Dynamic Polarization

    The principle that neuronal signals travel in one direction from dendrites to axon terminals.

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    Active vs Passive Transport

    Active transport requires energy to move substances against the concentration gradient; passive transport does not.

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    Action Potential (AP)

    A rapid change in membrane potential that propagates along a neuron.

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    Agonist vs. Antagonist

    Agonists activate receptors; antagonists block them.

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    Endogenous vs. Exogenous

    Endogenous ligands are produced within the body; exogenous come from outside.

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    Neuromuscular Junction (NMJ)

    The synapse between a motor neuron and a muscle fiber.

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    Ca2+ in Synaptic Transmission

    Calcium ions enter the axon terminal to trigger neurotransmitter release.

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    Learning

    The process of acquiring new knowledge or skills through experiences.

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    Memory

    The ability to store, retain, and recall information when needed.

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    Classical Conditioning

    A learning process where a neutral stimulus becomes associated with a meaningful stimulus.

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    Unconditioned Stimulus

    A stimulus that naturally and automatically triggers a response without prior learning.

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    Hippocampus

    A brain region crucial for memory consolidation, especially for spatial and declarative memory.

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    Anterograde Amnesia

    Inability to form new memories after a brain injury or trauma.

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    Procedural Memory

    A type of long-term memory for skills and actions, often performed without conscious awareness.

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    LTP (Long-Term Potentiation)

    A lasting increase in synaptic strength following high-frequency stimulation of a synapse.

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    Study Notes

    Lecture 1: History and Intro to Neurons

    • Definitions:
      • Trephination: Practice of drilling holes in the skull
      • Phrenology: Study of the skull's surface to determine personality
      • Equipotentiality: Idea that all parts of the brain have equal potential.
      • Golgi staining: Technique to visualize neurons
      • Synapse: Junction between two neurons
      • Nucleus: Control center of a cell
      • Ribosomes: Involved in protein synthesis
      • Cell Theory: Living things are composed of cells
      • Neuron Doctrine: Neurons are the basic units of the nervous system
    • Neurons:
      • Axon, dendrite, soma, synaptic terminal
      • Law of Dynamic Polarization: Neuronal information flows in one direction.
      • Sensory, Motor, Interneurons: Classification of neurons
      • Presynaptic vs Postsynaptic neurons: Neuron before and after the synapse.
      • Neuron and glial cells
    • Neuroscience History:
      • Combination of phrenology and equipotentiality: Current neuroscience combines aspects of both earlier ideas.
      • Ramon y Cajal's contribution: Key figure in the development of the neuron doctrine.
    • Dynamic Polarization: Neuronal information flows in one direction
    • Neuron Parts:
      • Functional boundaries of each part

    Lecture 2: Cell Biology of Neurons

    • Definitions:
      • Nucleus: Control center of a cell
      • Endoplasmic reticulum: Network of membranes in the cell
      • Golgi apparatus: Involved in processing proteins
      • Mitochondria: Powerhouse of the cell (energy production)
      • Cytoskeleton: Provides structure and support to the cell
      • Plasma membrane: Boundary of the cell
      • Genotype: Genetic makeup of an organism
      • Phenotype: Observable characteristics influenced by the genotype
    • Concepts:
      • Kinesin and dynein: Motor proteins for intracellular transport
      • Anterograde vs Retrograde transport: Movement within the neuron
      • Condensation reaction to form polypeptides: How proteins are built
      • Levels of protein structure: Primary, secondary, tertiary, quaternary
      • Characteristics of proteins/amino acids
      • Beta-amyloid and neurofibrillary tangles/plaques: Structures that can correlate with brain disorders
      • Plasma membrane properties: Hydrophobic (water-repelling) vs hydrophilic (water-attracting)
      • Passive vs Active transport: Various mechanisms for moving things across the membrane.

    Lecture 3: Membrane Potentials

    • Definitions/Concepts:
      • Selectively permeable: Membrane property allowing some molecules to pass but not others - Electrochemical gradient: Driving force for ion movement
      • Ohm's Law: Relationship between current, voltage, and resistance
      • Nernst Equation: Calculates equilibrium potential for a single ion - Goldman Equation: Calculates equilibrium potential for multiple ions
      • Conductance: Ability of a membrane to allow ions to pass
      • Equilibrium potential: Voltage at which the net flow of an ion across a membrane is zero.
      • Membrane potential: Voltage across a cell's membrane.
      • Current: Flow of ions across the membrane
      • Leak Channels
      • Na+/K+ Pump: Maintains ion gradients
      • Ion concentrations inside v. outside
      • Membrane potential changes as a result of changing ion concentrations.
      • Resting membrane potential, equilibrium potentials.

    Lecture 4: Action Potentials

    • Definitions/Concepts:
      • Action potential (AP): Rapid, transient change in membrane potential - Rising Phase/ Falling phase/ Repolarization/ Undershoot
      • Refractory Period: Brief time after an action potential where another cannot be generated
      • Tetrodotoxin (TTX): Blocks voltage-gated sodium channels
      • Depolarization vs Hyperpolarization: Changes in membrane potential
      • Voltage-gated vs. ligand-gated vs. leak channels: Different types of channels
      • Sodium channels vs Potassium channels; feedback loops
      • Ionic basis of the action potential
      • Ion movements/current changes in membrane potential (Vm)

    Lecture 5: AP Conduction

    • Definitions/Concepts:
      • Conduction Velocity
      • Membrane resistance, capacitance and internal resistance
      • Myelination - nodes of ranvier effect on AP (Saltatory Conduction)
      • CNS
      • Invertebrate vs Vertebrate solution
      • Relative speed of myelinated vs unmyelinated axons
      • Location of Sodium and Potassium channels
      • Astrocytes vs Schwann Cells
      • Membrane properties (Cm, Rm, Ri) affect action potential propagation
      • How myelination speeds up action potentials

    Lecture 6: Multiple Sclerosis (MS)

    • Symptoms of MS: Description of the symptoms
    • Neural mechanisms underlying memory formation: Description of the mechanisms

    Lecture 7 & 8: Synaptic Transmission

    • Definitions/Concepts:
      • Affinity/Potency/agonist/antagonist/ligands/exogenous/endogenous/neurotransmitter
      • Neuromuscular junction
      • Synaptic vesicle/SNARE complex
      • Acetylcholinesterase/Acetylcholine receptor/ GABA Receptor
      • Local v. long distance signaling/Agonist v. antagonist
      • Excitatory and Inhibitory postsynaptic potentials.
      • Synapses
      • Spatial and temporal summation
      • Postsynaptic potentials/action potentials
      • Step-by-step description of transmitter release

    Lecture 8 & 9: Learning and Memory

    • Definitions:
      • Learning
      • Memory
      • Classical conditioning
      • Conditioned/unconditioned stimuli
      • Hippocampal place cells
      • Hebb's postulate
      • Magnesium block
      • Glutamate receptor sensitization
      • Habituation
    • Memory types: description of different types of memory (declarative, procedural, etc.)
    • Mechanisms: description of the mechanisms involved in the storage and retrieval of memories
    • Different receptors: AMPA vs NMDA receptors are described
    • Learning examples: Description of examples like taxi v bus drivers

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    Description

    Explore the fundamental concepts of neurons, their structure, and the historical context of neuroscience in Lecture 1. This quiz covers essential definitions, types of neurons, and significant theories shaping our understanding of the nervous system.

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