Introduction to Human Pathogenic Bacteria: Extracellular vs Intracellular Lifecycle

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What protects intracellular pathogens from humoral antibodies?

  • Effector proteins
  • Membrane-disrupting enzymes
  • Cellular immune response (correct)
  • Specialized mechanisms

Which type of pathogens can only reproduce inside host cells?

  • Listeria monocytogenes
  • Salmonella spp.
  • Mycobacterium leprae (correct)
  • Legionella pneumophila

What is the purpose of exoenzymes produced by pathogens during invasion?

  • To trigger an immune response
  • To facilitate colonization of host tissues (correct)
  • To destroy host cells
  • To neutralize lysosomal enzymes

Which bacteria exploit nutrients in the host cell during their intracellular 'lifestyle'?

<p>Chlamydia spp. (C)</p> Signup and view all the answers

What is a characteristic feature of facultative intracellular pathogens?

<p>They can reproduce both inside and outside of host cells. (A)</p> Signup and view all the answers

Which mechanism allows Listeria monocytogenes to spread from one host cell to another?

<p>Replication in the host cell cytosol (C)</p> Signup and view all the answers

What is a characteristic feature of obligate intracellular bacteria mentioned in the text?

<p>Requirement of viable eukaryotic host cells for growth (C)</p> Signup and view all the answers

What is the role of the pore-forming toxin LLO in the context of Listeria infection?

<p>Facilitates escape from the phagosome (B)</p> Signup and view all the answers

Which bacterium is mentioned as an example of an obligate intracellular pathogen in the text?

<p>Coxiella burnetii (D)</p> Signup and view all the answers

What is the primary action of chlamydial elementary bodies (EB) upon attachment to epithelial cells?

<p>Prevent fusion of phagosome with host lysosome (C)</p> Signup and view all the answers

What is the primary function of effector proteins secreted by certain pathogens during invasion into host cells?

<p>Trigger entry into host cell (D)</p> Signup and view all the answers

Which bacterial mechanism of invasion relies on surface proteins binding to receptors on host cell membranes?

<p>Zipper mechanism (A)</p> Signup and view all the answers

What is the significance of avoiding the microbicidal lysosome for intracellular survival strategies of pathogens?

<p>To subvert endosomal trafficking (C)</p> Signup and view all the answers

Which bacterial pathogen utilizes effector molecules to cause membrane ruffles in the process of membrane ruffling during invasion?

<p>Salmonella (B)</p> Signup and view all the answers

What is a common strategy used by intracellular pathogens to enhance protection against immune recognition?

<p>Remodeling of the vacuole (A)</p> Signup and view all the answers

How do Mycobacterium tuberculosis, Legionella pneumophila, and Salmonella species evade being digested by the phagocyte?

<p>Prevent fusion of phagosome with lysosome and remain alive and dividing within the phagosome (C)</p> Signup and view all the answers

What is the mechanism used by Salmonella to evade the host's immune system after entering macrophages?

<p>Prevent fusion of the phagosome with the lysosome and proliferate within the SCV (C)</p> Signup and view all the answers

How do L.monocytogenes and Shigella escape the phagosome and multiply within the cytoplasm?

<p>Prevent lysis of the phagosome to maintain intracellular survival (D)</p> Signup and view all the answers

What is the main strategy used by intracellular pathogens like Mycobacterium tuberculosis to survive within phagocytes?

<p>Prevent fusion of phagosome with lysosome and remain alive within it (A)</p> Signup and view all the answers

How does Legionella pneumophila differ in its intracellular survival strategy compared to Mycobacterium tuberculosis?

<p><strong>Legionella pneumophila</strong> prevents lysis of the phagosome for intracellular survival (A)</p> Signup and view all the answers

Which term describes the Coxiella burnetii compartment where it replicates inside alveolar macrophages?

<p>Coxiella-containing vacuole (CCV) (A)</p> Signup and view all the answers

Which of the following is NOT an obligate intracellular bacteria from the Rickettsiales group mentioned in the text?

<p>Streptococcus pyogenes (C)</p> Signup and view all the answers

What is the degradative pathway involving lysosomes and cytosolic content that plays a role in cellular homeostasis and innate immunity?

<p>Autophagy (B)</p> Signup and view all the answers

Which bacterial pathogen uses ActA, Phospholipase C, and Autolysosome for intracellular survival and replication?

<p>Listeria monocytogenes (C)</p> Signup and view all the answers

What factor explains the limited niche for bacterial replication in different cell types due to the failure of bacteria to use cytosolic substrates?

<p>Bacterial tropism (A)</p> Signup and view all the answers

What is a common strategy employed by intracellular pathogens to resist being destroyed inside host cells?

<p>Preventing phagolysosome fusion (A)</p> Signup and view all the answers

Which category of bacteria is likely to possess effector proteins that aid in invasion of host cells?

<p>Obligate intracellular bacteria (B)</p> Signup and view all the answers

Phagosomal membrane disruption is a critical step for some pathogens to survive intracellularly. Which mechanism is commonly employed for this disruption?

<p>Interference with actin polymerization (C)</p> Signup and view all the answers

Intracellular survival mechanisms often involve acquiring nutrients within host cells. What is a typical nutrient source for these bacteria?

<p>Host cell cytoplasm (D)</p> Signup and view all the answers

Obligate intracellular bacteria have specialized adaptation for survival. Which of these characteristics is typically associated with this group of pathogens?

<p>Dependence on host cells for replication (A)</p> Signup and view all the answers

What is the role of haemolysin C and phospholipases in the escape strategy of Rickettsia prowazekii?

<p>Disrupting the vacuolar membrane (D)</p> Signup and view all the answers

What is a common feature of cytosolic pathogens during cell-to-cell spread?

<p>Enclosed in a secondary double-membrane vacuole (D)</p> Signup and view all the answers

Why do cytosolic bacteria polymerize actin at the bacterial pole?

<p>For intracellular and intercellular motility (C)</p> Signup and view all the answers

What is the immediate result of bacteria entering the host cell in a primary vacuole?

<p>Secretion of bacterial escape proteins (B)</p> Signup and view all the answers

Which step follows bacterial internalization in a secondary vacuole during cell-to-cell spread?

<p>Disruption of double-membrane vacuole membranes (B)</p> Signup and view all the answers

What is the significance of bacteria being free in the cytosol for obligate intracellular pathogens?

<p>It signifies escape from host cell vacuoles (A)</p> Signup and view all the answers

How do bacteria facilitate their entry into host cells during the initial stages of infection?

<p>Through secretion of bacterial escape proteins (D)</p> Signup and view all the answers

Flashcards are hidden until you start studying

More Like This

Pathogenic Bacteria Quiz
3 questions

Pathogenic Bacteria Quiz

DignifiedUvarovite avatar
DignifiedUvarovite
Micro bacteria  3
65 questions

Micro bacteria 3

CleanlyBoston avatar
CleanlyBoston
Introduction to Enterobacteriaceae
28 questions
Use Quizgecko on...
Browser
Browser