Introduction to Genetics
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Questions and Answers

Which of the following is NOT a base found in DNA?

  • Guanine
  • Cytosine
  • Uracil (correct)
  • Adenine
  • What is the function of telomerase?

  • Repair of telomeres (correct)
  • Replication of DNA
  • Production of proteins
  • Breakdown of DNA
  • What is the primary reason accurate DNA replication is crucial?

  • It enables the proper functioning of cellular processes and avoids tumor formation. (correct)
  • It ensures the production of identical daughter cells during mitosis.
  • It guarantees the formation of viable gametes for sexual reproduction.
  • It prevents the development of harmful mutations and genetic disorders.
  • Which enzyme plays a central role in DNA replication by adding complementary bases to a newly forming chain?

    <p>Polymerase (A)</p> Signup and view all the answers

    Which of the following correctly pairs the DNA bases?

    <p>Adenine - Thymine, Guanine - Cytosine (D)</p> Signup and view all the answers

    What is the role of filler DNA in the cell?

    <p>To contain signals for starting and stopping protein synthesis (D)</p> Signup and view all the answers

    What distinguishes meiosis from mitosis in terms of the number of daughter cells produced?

    <p>Meiosis produces four daughter cells, while mitosis produces two. (A)</p> Signup and view all the answers

    Which of the following statements about mitochondrial DNA is TRUE?

    <p>Mitochondrial DNA codes for proteins involved in cellular respiration. (B)</p> Signup and view all the answers

    What is the significance of the mixing of parental genes during meiosis?

    <p>It contributes to the genetic diversity within a species, leading to variations in traits. (A)</p> Signup and view all the answers

    What does the term 'alleles' refer to within the context of genetics?

    <p>Different versions of a gene that code for the same trait. (D)</p> Signup and view all the answers

    How is the genetic code read during protein synthesis?

    <p>The sequence of bases in RNA determines the order of amino acids in a protein. (C)</p> Signup and view all the answers

    What is the relationship between telomerase and cell senescence?

    <p>Reduced telomerase activity is associated with increased cell senescence. (A)</p> Signup and view all the answers

    What is the defining characteristic of a homozygous individual?

    <p>They possess two identical alleles for a particular trait. (E)</p> Signup and view all the answers

    How does the DNA molecule maintain its three-dimensional shape?

    <p>By the interaction of DNA with histones. (C)</p> Signup and view all the answers

    How does co-dominance differ from traditional dominant-recessive inheritance?

    <p>In co-dominance, both alleles are expressed equally, while in dominant-recessive, only one allele is dominant. (A)</p> Signup and view all the answers

    What is the biological significance of the ABO blood grouping system?

    <p>It classifies individuals based on the presence of specific antigens on red blood cells. (B)</p> Signup and view all the answers

    Which of the following statements is true concerning chromosomes?

    <p>Human cells have 23 pairs of chromosomes, with each pair coming from a parent. (D)</p> Signup and view all the answers

    What is the term for the complete set of chromosomes from a cell?

    <p>Karyotype (C)</p> Signup and view all the answers

    What is the function of the telomere?

    <p>To protect the ends of the chromosome from damage. (B)</p> Signup and view all the answers

    Which of the following is NOT true about histones?

    <p>They are made up of DNA. (C)</p> Signup and view all the answers

    What are the first 22 pairs of chromosomes called?

    <p>Autosomes (B)</p> Signup and view all the answers

    Which of the following is a diploid cell?

    <p>A cell with 23 pairs of chromosomes (C), A skin cell (D)</p> Signup and view all the answers

    Which of these is NOT a characteristic of autosomes?

    <p>They determine the sex of an individual. (A)</p> Signup and view all the answers

    Why does the Y chromosome only appear in males?

    <p>The Y chromosome is only passed down from the father. (C)</p> Signup and view all the answers

    What is the primary consequence of a faulty gene for the enzyme phenylalanine hydroxylase?

    <p>Accumulation of phenylalanine in the liver and bloodstream (B)</p> Signup and view all the answers

    Which of the following statements accurately describes the relationship between mRNA and DNA?

    <p>mRNA is a single-stranded molecule that carries genetic information from the DNA in the nucleus to the cytoplasm for protein synthesis. (A)</p> Signup and view all the answers

    What is the primary reason for the characteristic "meowing cry" in children with Cri-du-Chat syndrome?

    <p>Abnormalities in the larynx due to a missing chromosome segment (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic feature of Down's syndrome?

    <p>Absence of learning disabilities (B)</p> Signup and view all the answers

    What is the primary function of proteins in the human body?

    <p>To provide structural support and facilitate biochemical processes. (A)</p> Signup and view all the answers

    Which of the following statements about mitochondrial abnormalities is TRUE?

    <p>Mitochondrial mutations can be caused by genetic inheritance or spontaneous mutations. (A)</p> Signup and view all the answers

    What is the difference between mitosis and meiosis?

    <p>Mitosis produces two identical daughter cells with the full number of chromosomes, while meiosis produces four genetically diverse gametes with half the number of chromosomes. (D)</p> Signup and view all the answers

    Which of the following accurately describes the process of DNA replication?

    <p>DNA replicates by separating into two strands, each of which serves as a template for the synthesis of a new complementary strand. (A)</p> Signup and view all the answers

    What is the primary reason for the high incidence of Down's syndrome in mothers over 35 years of age?

    <p>Increased risk of defective egg cells with an extra chromosome 21 (D)</p> Signup and view all the answers

    What is a major potential danger associated with the accumulation of phenylalanine in the bloodstream?

    <p>Toxicity to the central nervous system (D)</p> Signup and view all the answers

    What is meant by a 'heritable alteration' in the genetic makeup of a cell?

    <p>A change in the sequence of DNA bases that can be passed on to offspring. (A)</p> Signup and view all the answers

    Which of the following conditions is NOT caused by chromosomal abnormalities?

    <p>Phenylketonuria (A)</p> Signup and view all the answers

    Which of the following is NOT a difference between DNA and RNA?

    <p>DNA is found in the cytoplasm, while RNA is found in the nucleus. (A)</p> Signup and view all the answers

    What process is responsible for the development of gametes carrying abnormal chromosomes?

    <p>Faulty chromosome separation during meiosis (C)</p> Signup and view all the answers

    What is the role of regulatory substances in gene expression?

    <p>To control which genes are expressed and at what levels in each cell type. (A)</p> Signup and view all the answers

    Why is the production of gametes different from the production of other body cells?

    <p>Gametes are produced by meiosis, while other body cells are produced by mitosis. (A)</p> Signup and view all the answers

    What is the most likely outcome for a female who inherits a faulty copy of the gene for color vision?

    <p>She will be a carrier of the color blindness gene. (C)</p> Signup and view all the answers

    What is the primary cause of cancer at the cellular level?

    <p>Mutations in cellular DNA. (B)</p> Signup and view all the answers

    Why does the incidence of cancer increase with age?

    <p>Cells acquire increasing numbers of mutations as they age, affecting their growth patterns. (B)</p> Signup and view all the answers

    Which of the following is NOT a direct consequence of the telomere function declining with age?

    <p>Cells become more susceptible to DNA damage. (C)</p> Signup and view all the answers

    Which of the following is NOT an example of a sex-linked trait?

    <p>Cystic fibrosis (A)</p> Signup and view all the answers

    What is the significance of the fact that the Y chromosome is smaller than the X chromosome?

    <p>It explains why males are more likely to have genetic disorders. (A)</p> Signup and view all the answers

    What is the role of telomerase in the context of cell division?

    <p>Telomerase adds nucleotides to the ends of chromosomes, preventing them from shortening. (A)</p> Signup and view all the answers

    Which of the following statements about blood type inheritance is TRUE?

    <p>Only the O allele is recessive, while A and B alleles are codominant. (A)</p> Signup and view all the answers

    Flashcards

    DNA Replication

    The process of copying DNA to produce identical molecules.

    Meiosis

    The process that produces gametes with half the chromosome number, involving two cell divisions.

    Zygote

    The diploid cell formed when a sperm cell and ovum unite.

    Genetic Diversity

    Variation in genes among individuals, crucial for evolution.

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    Alleles

    Different forms of a gene found on homologous chromosomes.

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    Homozygous

    Having two identical alleles for a particular gene.

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    Heterozygous

    Having two different alleles for a specific gene.

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    Co-dominance

    Condition where both alleles are expressed in the phenotype.

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    Alleles in Blood Types

    An individual can have combinations of AA, AB, BB, Ao, Bo, or oo alleles for blood types.

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    Dominant vs Recessive

    A and B alleles are dominant; O is recessive.

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    Sex-Linked Inheritance

    Traits coded on the X chromosome without Y counterparts are sex-linked.

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    X Chromosome Genes

    X chromosome carries over 2000 genes for male traits; Y has about 200.

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    Color Blindness Inheritance

    A recessive gene on X causes color blindness; males are more affected.

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    Cell Division Limit

    Cells can divide 50-60 times before telomere function declines with age.

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    Cancer and Ageing

    Cancer arises from mutations in DNA that accumulate with age.

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    Inherited Diseases

    Diseases like cystic fibrosis are inherited via faulty genes; mapped on human genome.

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    Mutation

    A heritable change in the genetic make-up of a cell.

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    Chromosomes

    Complete set of genetic material in a cell, shown in a karyotype.

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    Protein Synthesis

    Process where DNA instructions create proteins, essential for body function.

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    mRNA

    Single-stranded molecule carrying genetic instructions from DNA to ribosomes.

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    Gene Expression

    Process where cells use specific genes to perform their functions.

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    Diploid

    Cells with two sets of chromosomes, one from each parent.

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    Haploid

    Cells with one set of chromosomes, found in gametes.

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    Homologous Chromosomes

    Chromosome pairs, one from each parent, with similar genetic material.

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    Karyotype

    The complete set of chromosomes in a cell, arranged in pairs.

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    Autosomes

    The first 22 pairs of chromosomes, not involved in determining sex.

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    Sex Chromosomes

    The 23rd pair of chromosomes, determining gender (X and Y).

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    Telomere

    The protective cap at the end of a chromosome, crucial for stability.

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    Phenylketonuria (PKU)

    A genetic disorder caused by a defect in the enzyme phenylalanine hydroxylase, leading to toxic levels of phenylalanine.

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    Mitochondrial DNA defects

    Mutations in mitochondrial DNA that can lead to inherited disorders, often affecting muscles and the nervous system.

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    Chromosomal abnormalities

    Errors during meiosis resulting in gametes with abnormal chromosome numbers or shapes, leading to various syndromes.

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    Down’s syndrome

    A condition caused by an extra copy of chromosome 21, characterized by physical traits and varying degrees of learning disabilities.

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    Cri-du-Chat syndrome

    A genetic disorder resulting from a missing part of chromosome 5, noted for its crying sound and associated disabilities.

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    Mitochondrial mutations

    Changes in mitochondrial genes that can occur spontaneously in adulthood, potentially leading to diseases like diabetes or Parkinson’s.

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    Sex chromosome abnormalities

    Errors in the separation of sex chromosomes during meiosis, which can result in conditions like Turner or Klinefelter syndrome.

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    Learning disabilities in genetic disorders

    Cognitive challenges often associated with certain genetic conditions, including Down’s syndrome and cri-du-chat syndrome.

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    Gene

    A segment of DNA that codes for a specific protein.

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    Human genome

    The complete set of genes in a human being, approximately 20,500 genes.

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    DNA structure

    DNA is a double-stranded helix made of nucleotides.

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    Base pairing

    Specific pairing of DNA bases: A with T, C with G.

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    Mitochondrial DNA

    DNA located in mitochondria, inherited maternally.

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    Chromatin

    DNA-wrapped histones that form a coiled structure in the nucleus.

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    Study Notes

    Introduction to Genetics

    • All living organisms need to reproduce to continue their species
    • Offspring inherit genetic information from parents, ensuring the continuation of the species
    • DNA is organized into functional units called genes, which are part of larger structures called chromosomes
    • The complete set of genetic material in a cell is called a genome
    • Genetics is the study of genes, with significant impact on daily life (e.g., genetic counseling, insulin production)
    • Human reproduction is sexual, combining genetic material from two parents to create genetically unique offspring
    • The Human Genome Project mapped all chromosomes and genes, crucial for understanding and treating inherited diseases
    • Ageing has an impact on chromosomes, cell division, and heredity, discussed in the text

    Chromosomes, Genes, and DNA

    • Chromosomes are numbered, largest being number 1.
    • The first 22 pairs are called autosomes, and they have the same amount of genetic material in each
    • The 23rd pair are sex chromosomes (X and Y), they determine gender and are not necessarily the same size
    • Human cells have 46 chromosomes (23 pairs) arranged as a Karyotype
    • Nearly every body cell has an identical copy of the entire genetic material; this material is called chromatin
    • Chromosomes are visible structures during cell division that compact genetic material in cells.
    • Chromosomes are composed of DNA coiled around proteins called histones
    • Chromosomes are capped with a section of DNA called telomeres
    • Telomeres help seal the chromosome and are important in replication
    • Telomerase helps repair shortened telomeres

    DNA

    • DNA is double-stranded, made of two chains of nucleotides
    • Nucleotides consist of sugar, a phosphate, and a base
    • DNA bases paired are: Adenine pairs with Thymine; Guanine pairs with Cytosine
    • DNA structure is a double helix
    • DNA is a twisted ladder structure formed by alternating sugar and phosphate units
    • Each base binds to a specific complementary base on the opposite strand
    • The bases pair to create a specific code that carries genetic information
    • Some 99% of DNA does not code for proteins but signals start and stop for protein synthesis
    • The human genome has about 20,500 genes
    • Genes exist in pairs, one inherited from each parent
    • DNA's sequence carries genetic instructions crucial for organismal activities and inheritance

    Genes

    • Genes are the fundamental unit of heredity
    • Genes are sections of DNA
    • Genes can be dominant or recessive
    • Some genes can have multiple alleles to code for specific traits

    Protein Synthesis

    • Protein synthesis involves two main steps, transcription and translation
    • Transcription copies genetic information in DNA into a messenger RNA (mRNA) molecule
    • Translation uses mRNA information to synthesize proteins by linking amino acids
    • Proteins are essential for all aspects of bodily functions, structural and enzymatic

    Cell Division

    • Mitosis produces two identical diploid daughter cells
    • Meiosis produces four genetically different haploid daughter cells
    • DNA replication happens before both mitosis and meiosis
    • Cell division plays a vital role in growth, repair, and producing gametes (sperm and eggs), essential for continued reproduction

    Gene Expression

    • Gene expression refers to the use of specific genes for particular functions of cells, and involves turning genes on and off
    • This variation depends on the cell's function
    • All nucleated cells except gametes start with an identical set of genes
    • Gene expression ensures cells develop differently, expressing only necessary genes to perform their task

    Genetic Basis of Human Inheritance

    • Autosomal inheritance explains how traits are passed through dominant and recessive genes
    • Co-dominance describes traits with more than two alleles (e.g., blood types)
    • Sex-linked inheritance involves traits carried on the X or Y chromosomes (examples: color blindness, hemophilia)

    Cancer

    • Cancer is caused by mutations in cellular DNA leading to uncontrolled cell growth
    • Mutations can be inherited or acquired through age or other factors
    • Cells acquire mutations that give properties of cancer cells
    • The occurrence of cancer increases with age

    Aging and Genetics

    • Cumulative exposure to mutagens and declining DNA repair mechanisms lead to mutations
    • Telomeres and telomerase function declines and impacts cell division and repair mechanisms
    • Mutations in mitochondria DNA impact cell function

    Chromosomal Abnormalities

    • Abnormalities occur due to errors during meiosis leading to incorrect number of chromosomes
    • Disorders caused by errors in the number and structure of chromosomes include Turner's and Klinefelter's syndromes, Down syndrome, and Cri-du-Chat syndrome

    Genetic Diseases

    • Inherited diseases arise from mutated genes
    • Examples of genetic diseases with examples mentioned in the text are Phenylketonuria, cystic fibrosis, hemophilia and muscular dystrophy

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    Description

    Explore the fundamental concepts of genetics in this quiz, including the inheritance of traits, the structure of DNA, and the importance of the Human Genome Project. Understand how genetic information is passed from parents to offspring and the role chromosomes play in this process.

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