Intranasal & Ocular Drug Delivery: Learning Outcomes with Dr. Vivek Trivedi
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Questions and Answers

What is a key advantage of nasal drug delivery mentioned in the text?

  • Low drug permeability
  • Bypassing hepatic first-pass metabolism (correct)
  • Inefficient absorption due to a small surface area
  • Exposure to harsh environmental conditions

    • Why is the nose considered an alternative route to the Central Nervous System (CNS) for drug delivery?

  • It has minimal drug permeability
  • Exposes drugs to harsh gastrointestinal conditions
  • Offers direct drug delivery to the brain through olfactory nerves (correct)
  • Causes rapid excretion of drugs from the body

    • What characteristic makes nasal delivery particularly convenient for long-term therapy patients?

  • Low patient compliance
  • Potential direct drug delivery to the brain
  • Convenience for patients in long-term therapy (correct)
  • Minimal drug absorption

    • Which condition is avoided by choosing nasal drug delivery over other routes?

    <p>Gastrointestinal conditions</p> Signup and view all the answers

    In what way does nasal drug delivery differ from traditional oral administration?

    <p>Avoidance of hepatic first-pass metabolism</p> Signup and view all the answers

    Why is nasal drug delivery considered non-invasive?

    <p>Involves administration through the nose without surgical procedures</p> Signup and view all the answers

    Which layer of the posterior segment is responsible for photoreception?

    <p>Neural retina</p> Signup and view all the answers

    Which of the following is NOT a disadvantage of ocular drug delivery systems?

    <p>Improved patient compliance</p> Signup and view all the answers

    Which of the following is NOT a limitation of ocular drug delivery systems?

    <p>Minimize precorneal drug loss</p> Signup and view all the answers

    Which of the following is NOT a precorneal factor influencing the bioavailability of topically applied ophthalmic drugs?

    <p>Ocular static and dynamic barriers</p> Signup and view all the answers

    Which of the following is NOT a characteristic of an ideal ocular drug delivery system?

    <p>Good corneal penetration</p> Signup and view all the answers

    Which of the following is NOT a disease affecting the posterior segment of the eye?

    <p>Cataract</p> Signup and view all the answers

    Which formulation approach has shown good potential for controlling the rate and extent of drug release in nasal formulations?

    <p>Nasal gels with bioadhesive polymers</p> Signup and view all the answers

    What factor affects the droplet size and dose accuracy of nasal spray systems, which can impact nasal deposition?

    <p>All of the above</p> Signup and view all the answers

    Which formulation approach has been studied to target the CNS using nanoscale carriers?

    <p>Nasal suspensions and emulsions</p> Signup and view all the answers

    What is the main limitation of nasal drops as a drug delivery system?

    <p>Both a and b</p> Signup and view all the answers

    Which formulation approach has shown improved retention and bioavailability of actives in comparison to liquid formulations?

    <p>Nasal powders containing bioadhesive polymers</p> Signup and view all the answers

    What is the most important issue affecting drug delivery via the nasal route?

    <p>Drug permeation through the nasal mucosa</p> Signup and view all the answers

    What is the main challenge associated with the use of nasal drops?

    <p>All of the above</p> Signup and view all the answers

    Which formulation approach is considered favourable for nasal drug delivery due to its intimate adherence to the nasal mucosal surface?

    <p>Nasal micellar and liposomal formulations</p> Signup and view all the answers

    What is the most critical factor affecting the bioavailability of drugs with high water solubility in nasal drug delivery?

    <p>Permeability across nasal epithelia</p> Signup and view all the answers

    Which formulation approach has been studied to prolong the residence time of drugs in the nasal cavity?

    <p>Nasal powders containing bioadhesive polymers</p> Signup and view all the answers

    What physicochemical property of drugs can influence nasal absorption?

    <p>Particle size</p> Signup and view all the answers

    Which nasal effect can hinder drug absorption due to poor membrane permeability?

    <p>Mucociliary clearance</p> Signup and view all the answers

    What is a significant anatomical factor that can reduce nasal drug absorption and bioavailability?

    <p>Atrophic rhinitis</p> Signup and view all the answers

    Which part of the nasal cavity covers the main area and is crucial for drug absorption?

    <p>Inferior turbinate</p> Signup and view all the answers

    What is a key aspect of the olfactory epithelium in rodents compared to humans?

    <p>Higher olfactory region percentage</p> Signup and view all the answers

    Which type of drug absorption mechanism involves simple diffusion across membranes?

    <p>Transcellular</p> Signup and view all the answers

    In drug absorption, what is affected by the lipophilicity of the active pharmaceutical ingredient (API)?

    <p>Transcellular mechanism efficiency</p> Signup and view all the answers

    Why do water-soluble drugs with molecular weight greater than 1000 Daltons exhibit poor bioavailability?

    <p>Inverse correlation with IN absorption</p> Signup and view all the answers

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