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Questions and Answers
Which organelle is responsible for protein sorting in the cell?
Which organelle is responsible for protein sorting in the cell?
- Golgi apparatus
- Endoplasmic reticulum (correct)
- Nucleus
- Lysosomes
Which of the following proteins is NOT bound to go to the rough endoplasmic reticulum (rER)?
Which of the following proteins is NOT bound to go to the rough endoplasmic reticulum (rER)?
- Golgi enzymes
- ER protein
- Cell surface proteins
- Lysosome enzymes (correct)
What is the function of the signal sequence on a protein?
What is the function of the signal sequence on a protein?
- Bind to docking sites on the ER membrane (correct)
- Initiate protein synthesis
- Direct insertion of nascent proteins into the ER
- Clipping off the signal sequence
What happens if a protein has a stop-transfer signal on its ER membrane protein?
What happens if a protein has a stop-transfer signal on its ER membrane protein?
What happens to the signal sequence on a protein after it is inserted into the ER?
What happens to the signal sequence on a protein after it is inserted into the ER?
Which of the following proteins is NOT bound to go to the rough endoplasmic reticulum (rER)?
Which of the following proteins is NOT bound to go to the rough endoplasmic reticulum (rER)?
Where is the synthesis of ER proteins initiated?
Where is the synthesis of ER proteins initiated?
What directs the insertion of nascent proteins into or across the ER membrane?
What directs the insertion of nascent proteins into or across the ER membrane?
What happens to the signal sequence on a protein after it is inserted into the ER?
What happens to the signal sequence on a protein after it is inserted into the ER?
What determines whether a protein goes into the ER or not if it does not have a stop-transfer signal on its ER membrane protein?
What determines whether a protein goes into the ER or not if it does not have a stop-transfer signal on its ER membrane protein?
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Study Notes
Protein Sorting and Synthesis
- The organelle responsible for protein sorting in the cell is the rough endoplasmic reticulum (rER).
- The protein that is NOT bound to go to the rER is the one that doesn't have a signal sequence.
- The signal sequence on a protein directs the protein to the rER for synthesis and insertion into the ER membrane.
- If a protein has a stop-transfer signal on its ER membrane protein, it will be anchored to the ER membrane.
- After a protein is inserted into the ER, the signal sequence is removed.
- Proteins that are synthesized in the rER have their synthesis initiated in the ribosomes.
- The signal recognition particle (SRP) directs the insertion of nascent proteins into or across the ER membrane.
- The presence or absence of a signal sequence determines whether a protein goes into the ER or not.
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