17 Questions
What is the likely cause of incompatible results with post-transfusion samples but compatible with pre-transfusion samples?
Anamnestic antibody response
What is the next step in investigation if both crossmatches are compatible but there is strong clinical evidence of acute immune hemolytic reaction?
Perform antibody detection tests using more sensitive techniques
What is the purpose of examining post-transfusion urine for the presence of free hemoglobin or hemosiderin?
To detect hemolysis
Why is it important to measure serum haptoglobin in both pre and post transfusion samples?
To assess hemolysis
What is the purpose of testing the donor unit for the corresponding antigen?
To identify the antigen responsible for the reaction
What is indicated by a negative hemolysis test and a negative DAT?
An acute immune hemolytic reaction has NOT occurred
What is the next step in investigation if there is a discrepancy in patient/donor identification?
Search appropriate records and notify physician-in-charge
What is the interpretation of a positive hemolysis test and/or a positive DAT?
Suggests the presence of coating antibodies in circulating cells
What is the purpose of repeating ABO/RH typing and antibody screening in further investigation?
To identify errors in labeling and/or identification
What is the result of incompatible crossmatch with both pre and post transfusion samples against the sample of the donor?
Error during pre-transfusion testing
What is the significance of antibody complement-coated cells being rapidly destroyed?
It indicates that an acute immune hemolytic reaction has NOT occurred
What is the primary purpose of the autocontrol test in an investigation of incompatible crossmatch?
To determine if the problem is due to either blood group isoantibody or nonspecific reaction
What is the potential cause of a positive reaction in the saline at 37°C stage of investigation?
Irregular antibody, autoagglutinin, or rouleaux formation
What is the importance of grading donor reactions in the investigation of suspected hemolytic transfusion reaction?
To determine if the reactions of incompatible blood are all of the same strength
What is the purpose of rechecking the Rh type in the investigation of incompatible crossmatch?
To confirm the correct selection of blood unit
What is the significance of a positive DAT result in the investigation of suspected hemolytic transfusion reaction?
It indicates the presence of irregular antibody
What is the primary step in the investigation of incompatible crossmatch?
Verifying the patient's identity
This quiz tests your understanding of interpreting hemolysis test results, including understanding negative results and discrepancy in patient/donor identification. It also covers searching records and notifying physicians.
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