Interpreting Hemolysis Test Results
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Questions and Answers

What is the likely cause of incompatible results with post-transfusion samples but compatible with pre-transfusion samples?

  • Presence of antibodies in the recipient's blood
  • Intrinsic red cell defect
  • Bacterial contamination of the donor unit
  • Anamnestic antibody response (correct)
  • What is the next step in investigation if both crossmatches are compatible but there is strong clinical evidence of acute immune hemolytic reaction?

  • Stop the transfusion immediately
  • Perform antibody detection tests using more sensitive techniques (correct)
  • Administer steroids to the patient
  • Repeat the crossmatch
  • What is the purpose of examining post-transfusion urine for the presence of free hemoglobin or hemosiderin?

  • To diagnose acute kidney injury
  • To detect hemolysis (correct)
  • To assess blood transfusion reaction
  • To monitor kidney function
  • Why is it important to measure serum haptoglobin in both pre and post transfusion samples?

    <p>To assess hemolysis</p> Signup and view all the answers

    What is the purpose of testing the donor unit for the corresponding antigen?

    <p>To identify the antigen responsible for the reaction</p> Signup and view all the answers

    What is indicated by a negative hemolysis test and a negative DAT?

    <p>An acute immune hemolytic reaction has NOT occurred</p> Signup and view all the answers

    What is the next step in investigation if there is a discrepancy in patient/donor identification?

    <p>Search appropriate records and notify physician-in-charge</p> Signup and view all the answers

    What is the interpretation of a positive hemolysis test and/or a positive DAT?

    <p>Suggests the presence of coating antibodies in circulating cells</p> Signup and view all the answers

    What is the purpose of repeating ABO/RH typing and antibody screening in further investigation?

    <p>To identify errors in labeling and/or identification</p> Signup and view all the answers

    What is the result of incompatible crossmatch with both pre and post transfusion samples against the sample of the donor?

    <p>Error during pre-transfusion testing</p> Signup and view all the answers

    What is the significance of antibody complement-coated cells being rapidly destroyed?

    <p>It indicates that an acute immune hemolytic reaction has NOT occurred</p> Signup and view all the answers

    What is the primary purpose of the autocontrol test in an investigation of incompatible crossmatch?

    <p>To determine if the problem is due to either blood group isoantibody or nonspecific reaction</p> Signup and view all the answers

    What is the potential cause of a positive reaction in the saline at 37°C stage of investigation?

    <p>Irregular antibody, autoagglutinin, or rouleaux formation</p> Signup and view all the answers

    What is the importance of grading donor reactions in the investigation of suspected hemolytic transfusion reaction?

    <p>To determine if the reactions of incompatible blood are all of the same strength</p> Signup and view all the answers

    What is the purpose of rechecking the Rh type in the investigation of incompatible crossmatch?

    <p>To confirm the correct selection of blood unit</p> Signup and view all the answers

    What is the significance of a positive DAT result in the investigation of suspected hemolytic transfusion reaction?

    <p>It indicates the presence of irregular antibody</p> Signup and view all the answers

    What is the primary step in the investigation of incompatible crossmatch?

    <p>Verifying the patient's identity</p> Signup and view all the answers

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