Podcast
Questions and Answers
What is the primary function of mast cells in the body?
What is the primary function of mast cells in the body?
- Inducing inflammation (correct)
- Producing lipid mediators and cytokines
- Releasing granular contents into the circulation
- Synthesizing lipid mediators from cell membrane precursors
Where are mast cells located in the body?
Where are mast cells located in the body?
- Close to a blood vessel in connective tissue (correct)
- In the alveoli of the lungs
- Within the lymphatic system
- Within the bloodstream
What happens when mast cells are activated?
What happens when mast cells are activated?
- They settle in nearby tissues
- They mature within circulation
- They release their granular contents into the circulation (correct)
- They produce histamine and serotonin
What is the relationship between mast cells and basophils?
What is the relationship between mast cells and basophils?
Which type of response are mast cells especially important in?
Which type of response are mast cells especially important in?
What is contained within mast cells' pre-formed granules?
What is contained within mast cells' pre-formed granules?
Which plasma protein system component is responsible for activation of the kinin system?
Which plasma protein system component is responsible for activation of the kinin system?
What is the role of histamine in the inflammatory response?
What is the role of histamine in the inflammatory response?
Which mediator is responsible for inducing bronchoconstriction and fever?
Which mediator is responsible for inducing bronchoconstriction and fever?
What is the major source of cell-derived mediators of inflammation?
What is the major source of cell-derived mediators of inflammation?
Which mediator plays a major role in the mediation of asthma and anaphylaxis?
Which mediator plays a major role in the mediation of asthma and anaphylaxis?
What are arachidonic metabolites released from?
What are arachidonic metabolites released from?
Which mediator is released mainly by mast cells, basophils, and platelets and promotes platelet aggregation?
Which mediator is released mainly by mast cells, basophils, and platelets and promotes platelet aggregation?
Where is histamine primarily found prior to its release during acute inflammation?
Where is histamine primarily found prior to its release during acute inflammation?
What is the consequence of histamine binding to H1 receptors on endothelial cells?
What is the consequence of histamine binding to H1 receptors on endothelial cells?
Which mediator induces smooth muscle contraction, small blood vessel dilation, and increased vascular permeability?
Which mediator induces smooth muscle contraction, small blood vessel dilation, and increased vascular permeability?
What do cytokines and chemokines do in the inflammatory response?
What do cytokines and chemokines do in the inflammatory response?
Which cell types produce cytokines and chemokines?
Which cell types produce cytokines and chemokines?
What is the role of nitric oxide (NO) in the inflammatory response?
What is the role of nitric oxide (NO) in the inflammatory response?
What is the function of oxygen-free radicals released by leukocytes?
What is the function of oxygen-free radicals released by leukocytes?
How does impaired production of nitric oxide (NO) affect inflammation?
How does impaired production of nitric oxide (NO) affect inflammation?
What cell response is caused by high levels of oxygen-free radicals?
What cell response is caused by high levels of oxygen-free radicals?
What is the primary role of cytokines and chemokines in inflammation?
What is the primary role of cytokines and chemokines in inflammation?
Which type of cells release low levels of oxygen-free radicals?
Which type of cells release low levels of oxygen-free radicals?
What effect does blocking nitric oxide (NO) production have on leukocyte recruitment?
What effect does blocking nitric oxide (NO) production have on leukocyte recruitment?
How do cytokines and chemokines affect the inflammatory response?
How do cytokines and chemokines affect the inflammatory response?
What is the function of nitric oxide in the inflammatory response?
What is the function of nitric oxide in the inflammatory response?
Which plasma protein system is responsible for the release of eosinophil chemotactic factor-A (ECF-A) to attract eosinophils to the site of inflammation?
Which plasma protein system is responsible for the release of eosinophil chemotactic factor-A (ECF-A) to attract eosinophils to the site of inflammation?
Which plasma protein system contributes to the inflammatory response by causing vasodilation, increasing vascular permeability, and enhancing activity of phagocytes?
Which plasma protein system contributes to the inflammatory response by causing vasodilation, increasing vascular permeability, and enhancing activity of phagocytes?
Which plasma protein system is activated by substances released during tissue destruction and infection, and enhances inflammation through the production of fibrinous network and other by-products?
Which plasma protein system is activated by substances released during tissue destruction and infection, and enhances inflammation through the production of fibrinous network and other by-products?
Which plasma protein system is composed of 20 different proteins, labelled C1 through C9, and is capable of direct destruction of pathogens or can activate and work with other components of the inflammatory response?
Which plasma protein system is composed of 20 different proteins, labelled C1 through C9, and is capable of direct destruction of pathogens or can activate and work with other components of the inflammatory response?
Which plasma protein system interacts closely with the clotting system and produces bradykinin which causes vasodilation, increases vascular permeability, and enhances leukocyte chemotaxis?
Which plasma protein system interacts closely with the clotting system and produces bradykinin which causes vasodilation, increases vascular permeability, and enhances leukocyte chemotaxis?
Which pathway of the complement cascade is activated by antibodies and requires at least two Ag-Ab complexes to initiate the cascade?
Which pathway of the complement cascade is activated by antibodies and requires at least two Ag-Ab complexes to initiate the cascade?
Which pathway of the complement cascade is activated by bacterial carbohydrates and is similar to the classical pathway, but does not require antibodies?
Which pathway of the complement cascade is activated by bacterial carbohydrates and is similar to the classical pathway, but does not require antibodies?
Which pathway of the complement cascade is activated by gram-negative bacterial and fungal cell wall polysaccharides (endotoxins) and begins with activation of C3b?
Which pathway of the complement cascade is activated by gram-negative bacterial and fungal cell wall polysaccharides (endotoxins) and begins with activation of C3b?
Which factor becomes Xa in the clotting system, providing a link between the coagulation system and inflammation?
Which factor becomes Xa in the clotting system, providing a link between the coagulation system and inflammation?
Which enzyme activates prekallekrein in the kinin cascade?
Which enzyme activates prekallekrein in the kinin cascade?
Which kininogen-derived peptide causes vasodilation, increases vascular permeability, enhances leukocyte chemotaxis, and stimulates pain receptors?
Which kininogen-derived peptide causes vasodilation, increases vascular permeability, enhances leukocyte chemotaxis, and stimulates pain receptors?
Which component causes rapid degranulation of mast cells, increasing the inflammatory response during the complement cascade?
Which component causes rapid degranulation of mast cells, increasing the inflammatory response during the complement cascade?
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