Integument Composition and Functions
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Questions and Answers

What percentage of the body weight does the integument account for?

7% to 8%

What is the range of thickness of the integument?

1.5 mm to 4 mm or more

What is the outermost layer of the integument called?

Epidermis

What type of connective tissue is found deep to the epithelium?

<p>Areolar and dense irregular connective tissue</p> Signup and view all the answers

What is the function of the arrector pili muscle?

<p>To alter hair position</p> Signup and view all the answers

What is the layer of tissue deep to the integument called?

<p>Subcutaneous layer or hypodermis</p> Signup and view all the answers

What type of tissue detects and monitors sensory stimuli in the integument?

<p>Nervous tissue</p> Signup and view all the answers

What is the area of the skin in square meters?

<p>Between about 1.5 and 2.0 square meters</p> Signup and view all the answers

What is the term for the epithelium of the integument?

<p>Epidermis</p> Signup and view all the answers

What is the range of thickness of the entire integument?

<p>1.5-4 mm</p> Signup and view all the answers

What is the name of the layer of the epidermis that contains dead cells?

<p>Stratum corneum</p> Signup and view all the answers

What type of cells are most abundant in the epidermis?

<p>Keratinocytes</p> Signup and view all the answers

What is the function of melanin in the epidermis?

<p>To shield nuclear DNA from UV radiation</p> Signup and view all the answers

What is the name of the cells sensitive to touch in the stratum basale?

<p>Tactile cells (Merkel cells)</p> Signup and view all the answers

What is the term for the single layer of cuboidal to low columnar cells in the deepest epidermal layer?

<p>Stratum basale</p> Signup and view all the answers

What is the name of the organelles that transfer melanin pigment to keratinocytes?

<p>Melanosomes</p> Signup and view all the answers

What type of protein do keratinocytes synthesize?

<p>Keratin</p> Signup and view all the answers

What is the term for the process of melanocytes producing melanin to block UV light?

<p>Tanning</p> Signup and view all the answers

What type of cell does a new cell in the stratum spinosum differentiate into?

<p>A nondividing, highly specialized keratinocyte</p> Signup and view all the answers

What is the function of desmosomes in the stratum spinosum?

<p>To provide structural support between cells of the epidermis</p> Signup and view all the answers

Why do keratinocytes in the stratum spinosum resemble miniature porcupines?

<p>Because the cytoskeleton and desmosomes remain intact after cytoplasm shrinkage during microscopic preparation</p> Signup and view all the answers

What is the role of epidermal dendritic (Langerhans) cells in the epidermis?

<p>To help fight infection by initiating an immune response</p> Signup and view all the answers

What process begins in the stratum granulosum?

<p>Keratinization</p> Signup and view all the answers

What is the function of the stratum lucidum?

<p>To help protect the skin from ultraviolet light</p> Signup and view all the answers

What is the composition of the stratum corneum?

<p>About 20 to 30 layers of dead, scaly, interlocking, keratinized cells</p> Signup and view all the answers

What is the result of keratinization in the stratum corneum?

<p>Keratin protein enclosed in a thickened plasma membrane</p> Signup and view all the answers

How long does the migration of a keratinocyte to the stratum corneum take?

<p>About 2 weeks</p> Signup and view all the answers

What is the result of the death of keratinocytes in the stratum corneum?

<p>Their keratin protein remains, forming the outermost layer of the epidermis</p> Signup and view all the answers

What is the function of hemoglobin in red blood cells, and how does it affect the color of blood vessels?

<p>Hemoglobin is an oxygen-binding protein that exhibits a bright red color upon binding oxygen, giving blood vessels in the dermis a reddish tint.</p> Signup and view all the answers

What are the two types of melanin, and what colors do they produce in the skin?

<p>The two types of melanin are eumelanin, which produces shades of brown and black, and pheomelanin, which produces lighter shades of tan, yellow, and red.</p> Signup and view all the answers

How does melanocyte activity affect the color of the entire epidermis?

<p>Melanocyte activity affects the color of the entire epidermis because melanin is transferred from melanocytes to keratinocytes in the stratum basale, which are then displaced towards the stratum corneum.</p> Signup and view all the answers

What is carotene, and where is it typically found in the skin?

<p>Carotene is a yellow-orange pigment acquired from yellow-orange vegetables, typically found in keratinocytes of the stratum corneum and in subcutaneous fat.</p> Signup and view all the answers

What is the difference in melanocyte activity between darker-skinned and lighter-skinned individuals?

<p>Darker-skinned individuals have melanocytes that produce more and darker melanin, which is packaged into cells in more superficial epidermal layers, such as the stratum granulosum.</p> Signup and view all the answers

How does exposure to UV light affect skin color, and what is the role of melanocytes in this process?

<p>Exposure to UV light stimulates melanocytes to produce more melanin, temporarily altering skin color. Melanocytes play a crucial role in this process by producing melanin in response to UV light.</p> Signup and view all the answers

What are the three forms of ultraviolet radiation, and how do they affect the skin?

<p>The three forms of ultraviolet radiation are UVA, UVB, and UVC. UVA and UVB rays can cause skin cancer and affect skin color, while UVC rays are absorbed by the upper atmosphere and do not reach the earth's surface.</p> Signup and view all the answers

What is the role of vitamin A in the body, and how is it related to carotene?

<p>Vitamin A plays an important role in vision and reduces free radicals in the body. It is converted from carotene in the liver.</p> Signup and view all the answers

How do UVA and UVB rays differ in their effects on the skin, and what is the myth about UVA rays?

<p>UVA rays are often referred to as tanning rays, while UVB rays are referred to as burning rays. However, UVA rays can also cause burning and suppress the immune system, debunking the myth that they are safe.</p> Signup and view all the answers

What is the relationship between melanin and skin color, and how is it influenced by heredity and environmental factors?

<p>Melanin gives skin its color, and the amount and type of melanin present in the epidermis determine an individual's skin color. Heredity and exposure to UV light influence melanin production and skin color.</p> Signup and view all the answers

What is the purpose of applying sunscreen liberally over all exposed body surfaces, and reapplying after being in the water or perspiring?

<p>To ensure complete protection of the skin from UVA and UVB rays.</p> Signup and view all the answers

How do sunless tanners produce a tanned, bronzed skin without UV light exposure?

<p>By interacting with amino acids in the epidermal cells to produce a darkened, brownish color.</p> Signup and view all the answers

What is the result of the nonfunctional enzyme needed to produce melanin in individuals with albinism?

<p>Melanocytes are unable to produce melanin, leading to white hair, pale skin, and pink irises.</p> Signup and view all the answers

What is the significance of monitoring nevi for changes?

<p>To detect possible malignancy, as nevi can develop into malignant melanomas due to excessive UV light exposure.</p> Signup and view all the answers

What is the difference between capillary hemangiomas and cavernous hemangiomas?

<p>Capillary hemangiomas are bright red to deep purple nodules that usually appear at birth and disappear in childhood, while cavernous hemangiomas involve larger dermal blood vessels and may last a lifetime.</p> Signup and view all the answers

What is the purpose of friction ridges on the palms, fingers, soles, and toes?

<p>To increase friction on contact, allowing firm grasping and preventing slipping, as well as providing flexibility to the skin.</p> Signup and view all the answers

What is the term for the study of friction ridge patterns?

<p>Dermatoglyphics</p> Signup and view all the answers

Why is it important to apply sunscreen when using sunless tanners?

<p>Because sunless tanners do not offer protection against UV rays, and protective melanin has not been produced.</p> Signup and view all the answers

What determines the degree of pigmentation in freckles?

<p>Both sun exposure and heredity.</p> Signup and view all the answers

What is the significance of the SPF number on sunscreens?

<p>It indicates the level of protection against UVB rays, with higher numbers providing longer protection from sunburn.</p> Signup and view all the answers

What purpose does the stratum corneum serve in the integument, and how long do the dead, keratinized cells remain in this layer?

<p>The stratum corneum provides a barrier against many microorganisms and helps prevent their growth on the epidermis. The dead, keratinized cells remain in this layer for about 2 weeks before they are shed.</p> Signup and view all the answers

What is the main difference between thick skin and thin skin, and where is each type typically found?

<p>The main difference is the number of layers and thickness of the stratified squamous epithelium. Thick skin has all five epidermal strata and is typically found on the palms of the hands and soles of the feet, while thin skin has only four epidermal strata and covers most body surfaces.</p> Signup and view all the answers

What are some exocrine gland secretions that help prevent the growth of microorganisms on the epidermis?

<p>Sweat, which contains demicidin, an antimicrobial peptide, is an example of an exocrine gland secretion that helps prevent the growth of microorganisms on the epidermis.</p> Signup and view all the answers

Why do you think thick skin lacks hair follicles and sebaceous glands?

<p>Thick skin lacks hair follicles and sebaceous glands likely because they would interfere with the function of skin in areas that require durability and resistance to wear and tear, such as the palms and soles.</p> Signup and view all the answers

What determines the normal skin color, and what are the contributors to this color?

<p>Normal skin color results from a combination of the colors of hemoglobin, melanin, and carotene.</p> Signup and view all the answers

How can you identify the epidermal strata using light microscopy, and what features should you look for?

<p>To identify the epidermal strata, determine the layer's proximity to the free surface, examine the shape of keratinocytes, check for the presence of nuclei, count the layers of keratinocytes, and look for visible granules in the cytoplasm.</p> Signup and view all the answers

What are the thickness ranges of the epidermis in thick skin and thin skin?

<p>The epidermis of thick skin is between 0.4 mm and 0.6 mm thick, while the epidermis of thin skin is between 0.075 mm and 0.150 mm thick.</p> Signup and view all the answers

What are the structures found in thin skin, and how do they differ from those found in thick skin?

<p>Thin skin contains hair follicles, sebaceous glands, and sweat glands, whereas thick skin lacks hair follicles and sebaceous glands, but has sweat glands.</p> Signup and view all the answers

What is the lifespan of individual keratinocytes in the integument, and how long do they remain in the stratum corneum?

<p>Individual keratinocytes are present in the integument for about 1 month following their formation, and they remain in the stratum corneum for about 2 weeks before being shed.</p> Signup and view all the answers

What is the significance of the stratum lucidum in thick skin, and how does it differ from thin skin?

<p>The stratum lucidum is present in thick skin, but absent in thin skin. It is a layer of dead, anucleate keratinocytes that provides additional barrier function to the epidermis.</p> Signup and view all the answers

What is the significance of the interlocking projections in the model of the epidermis and dermis?

<p>The interlocking projections represent the epidermal ridges and dermal papillae, which increase the surface area of interaction between the two layers.</p> Signup and view all the answers

What is the clinical significance of lines of cleavage in the skin?

<p>Lines of cleavage are clinically significant because they indicate the predominant direction of collagen fiber bundles, which can affect wound healing and scarring.</p> Signup and view all the answers

How do collagen and elastic fibers contribute to the physical characteristics of the skin?

<p>Collagen fibers impart tensile strength, while elastic fibers allow for stretch and recoil during normal movement activities.</p> Signup and view all the answers

What is the significance of friction ridge patterns in dermatoglyphics, and how do they form?

<p>Friction ridge patterns are a unique identifier because no two individuals, including identical twins, share the same set of fingerprints. They form fingerprints, palm prints, sole prints, and toe prints due to the formation of friction ridges.</p> Signup and view all the answers

What causes stretch marks, and how do they affect the skin?

<p>Stretch marks are caused by excessive stretching of the skin, which can tear collagen fibers and lead to the formation of striae. This can result in decreased skin elasticity and thickness.</p> Signup and view all the answers

What layers of the epidermis would be penetrated by a thorn, starting from the surface of the skin?

<p>The thorn would penetrate the stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale.</p> Signup and view all the answers

How do tattoos become permanent, and why is it difficult to remove them?

<p>Tattoos become permanent because the injected dye becomes surrounded by scar tissue in the dermis, which cannot be ingested by dendritic cells. This makes it difficult to remove tattoos without causing scarring.</p> Signup and view all the answers

Compare and contrast the papillary and reticular layers of the dermis.

<p>The papillary layer is thin and contains loose connective tissue, while the reticular layer is thicker and contains dense irregular connective tissue with collagen and elastic fibers.</p> Signup and view all the answers

Briefly describe the process of keratinization. Where does it occur, and why is it important?

<p>Keratinization is the process of producing keratin, a protein that provides strength and rigidity to the epidermis. It occurs in the stratum spinosum and stratum granulosum. It is important because it helps to protect the body from external damage.</p> Signup and view all the answers

How does hemoglobin contribute to skin color?

<p>Hemoglobin contributes to skin color by giving it a red or pinkish hue, especially in areas where blood vessels are close to the surface.</p> Signup and view all the answers

What is the function of the subcutaneous layer, and what type of tissue does it consist of?

<p>The subcutaneous layer provides cushioning and insulation, and consists of both areolar and adipose connective tissue.</p> Signup and view all the answers

How does the skin produce vitamin D?

<p>through the action of UV light on 7-dehydrocholesterol in the skin</p> Signup and view all the answers

What are the two major regions of the dermis, and what are their characteristics?

<p>The two major regions of the dermis are the papillary layer and the reticular layer. The papillary layer is superficial, composed of areolar connective tissue, and contains dermal papillae and capillaries. The reticular layer is deeper, composed of dense irregular connective tissue, and contains collagen fibers and structures like hair follicles and sebaceous glands.</p> Signup and view all the answers

What is the role of dermal papillae in the skin?

<p>Dermal papillae are projections of the dermis that increase the surface area of interaction with the epidermis, allowing for better exchange of nutrients and waste.</p> Signup and view all the answers

What is the function of dermal papillae, and how do they interact with epidermal ridges?

<p>Dermal papillae contain capillaries that supply nutrients to the epidermis and sensory nerve endings that serve as tactile receptors. They interdigitate with epidermal ridges, increasing the area of contact between the two layers and interlocking them.</p> Signup and view all the answers

How do surgical procedures take into account lines of cleavage in the skin?

<p>Surgeons plan incisions to be parallel to lines of cleavage to minimize scarring and promote rapid healing.</p> Signup and view all the answers

What type of connective tissue is found in the papillary layer, and what type is found in the reticular layer?

<p>The papillary layer is composed of areolar connective tissue, while the reticular layer is composed of dense irregular connective tissue.</p> Signup and view all the answers

What is the significance of cleavage lines in the dermis?

<p>Cleavage lines are not mentioned explicitly in the provided text. However, in general, cleavage lines are important in the dermis because they influence the direction of wound healing and the formation of scars.</p> Signup and view all the answers

What is the role of dendritic cells in the dermis, and how do they compare to epidermal dendritic cells?

<p>Dendritic cells in the dermis serve an immune function. They are similar to epidermal dendritic cells in that they also serve an immune function, but they are located in the dermis rather than the epidermis.</p> Signup and view all the answers

What structures are found within the dermis, and what is their significance?

<p>The dermis contains structures such as blood vessels, sweat glands, sebaceous glands, hair follicles, nail roots, sensory nerve endings, and smooth muscle tissue associated with hair follicles. These structures are significant because they provide various functions, including thermoregulation, sensation, and hair growth.</p> Signup and view all the answers

What is the primary function of the seven major types of sensory receptors housed within the skin?

<p>to detect, distinguish, and interpret the many stimuli of our external environment</p> Signup and view all the answers

How does exposure to ultraviolet light affect the dermis?

<p>Exposure to UV light causes the dermis to become less flexible and thinner, leading to sagging or wrinkled skin.</p> Signup and view all the answers

What is the significance of the dermis in relation to the skin's functions?

<p>it provides a well-vascularized connective tissue layer that supports the skin's functions, such as secretion, absorption, and temperature regulation</p> Signup and view all the answers

What are some ways the skin can dissipate excess heat?

<p>through sweating, vasodilation, and radiation</p> Signup and view all the answers

How does the anatomy of the integument support its various functions?

<p>through the combination of the epidermis and dermis, which together provide a protective barrier, regulate water loss and gain, and facilitate various other functions</p> Signup and view all the answers

What is the importance of the skin's immune function?

<p>it helps to protect the body against infection and disease by recognizing and responding to pathogens</p> Signup and view all the answers

What is the significance of the connective tissue fibers in the reticular layer of the dermis and subcutaneous layer?

<p>They are extensively interwoven to stabilize the position of the skin and bind it to the underlying structures.</p> Signup and view all the answers

Why are drugs often injected into the subcutaneous layer?

<p>Because of its extensive vascular network, which promotes rapid absorption of the drugs.</p> Signup and view all the answers

How do sex hormones influence the distribution of subcutaneous fat?

<p>Testosterone leads to accumulation primarily at the neck, upper arms, abdomen, lower back, and buttocks, while estrogen and progesterone lead to thicker overall fat and accumulation in the mammary regions, buttocks, hips, and thighs.</p> Signup and view all the answers

What is the primary function of the papillary layer of the dermis?

<p>It forms dermal papillae and houses capillaries and tactile receptors.</p> Signup and view all the answers

What are the two main functions of the integument in terms of temperature regulation?

<p>It helps retain warmth or cool the body by means of sweating and vasodilation.</p> Signup and view all the answers

How does the integumentary system interact with the immune system?

<p>Dendritic cells in the integument initiate an immune response.</p> Signup and view all the answers

What is the role of the integument in maintaining blood volume?

<p>It helps prevent fluid loss, thereby assisting the cardiovascular system in maintaining blood volume.</p> Signup and view all the answers

How does the integumentary system aid in the synthesis of vitamin D?

<p>It synthesizes vitamin D, which is required for calcium homeostasis.</p> Signup and view all the answers

What is the significance of hairs in the nasal cavity?

<p>They help filter inspired air, assisting the respiratory system.</p> Signup and view all the answers

What is the role of the integument in the excretion of nitrogenous waste products?

<p>It excretes nitrogenous waste products, along with the urinary system.</p> Signup and view all the answers

What is the main function of the skin in terms of protection from the external environment?

<p>The skin acts as a physical barrier that protects the entire body from the external environment, offering protection against harmful chemicals, toxins, microbes, and excessive heat or cold.</p> Signup and view all the answers

How does the skin prevent water loss and water gain?

<p>The epidermis is water resistant, but not entirely waterproof, and prevents water loss through transpiration and sweat. It also prevents water gain by being resistant to water absorption.</p> Signup and view all the answers

What is the role of keratinocytes in vitamin D synthesis?

<p>Keratinocytes in the epidermis convert a steroid molecule (7-dehydrocholesterol) to vitamin D3 in response to UV light exposure.</p> Signup and view all the answers

Why did children during the Industrial Revolution develop rickets?

<p>Children during the Industrial Revolution developed rickets due to inadequate vitamin D, likely resulting from limited sunlight exposure and inadequate dietary intake.</p> Signup and view all the answers

What is the skin's role in electrolyte homeostasis?

<p>The skin regulates electrolyte levels in the body through the excretion of sweat, which contains water, salts, and urea.</p> Signup and view all the answers

What is the significance of melanin in the epidermis?

<p>Melanin in the epidermis protects deeper tissues from solar radiation, especially UV rays, and provides a tanned look when exposed to sunlight.</p> Signup and view all the answers

How does the skin's secretory function contribute to thermoregulation?

<p>The skin's secretory function contributes to thermoregulation through the excretion of sweat, which acts to release excess heat from the body.</p> Signup and view all the answers

What is the role of corticosteroids in the skin?

<p>Topical corticosteroids are converted and used by keratinocytes to stop inflammation and itching.</p> Signup and view all the answers

How does the skin's water-resistant properties affect its role in preventing water gain?

<p>The skin's water-resistant properties prevent excessive water absorption, which would lead to edema and tissue damage.</p> Signup and view all the answers

What is the relationship between vitamin D synthesis and UV light exposure in the skin?

<p>Vitamin D synthesis in the skin is initiated in response to UV light exposure, which triggers the conversion of 7-dehydrocholesterol to vitamin D3.</p> Signup and view all the answers

What is the function of sebaceous glands in the skin?

<p>to lubricate the epidermis and hair, and help make the integument water resistant</p> Signup and view all the answers

How do transdermal patches work to administer drugs?

<p>by releasing a continual, slow absorption of the drug into the blood over a relatively long period of time</p> Signup and view all the answers

What is the effect of vasoconstriction on dermal blood vessels?

<p>it shunts blood away from the periphery of the body and toward deeper structures, conserving heat</p> Signup and view all the answers

What is the function of epidermal dendritic cells in the immune response?

<p>to initiate an immune response against pathogens that have penetrated the skin</p> Signup and view all the answers

What is the effect of vasodilation on dermal blood vessels?

<p>it shunts blood to the periphery of the body and away from deeper structures, releasing excess heat</p> Signup and view all the answers

Why is the skin selectively permeable?

<p>because the epidermis is composed of cells, allowing for the unregulated passage of small, nonpolar molecules through the plasma membrane</p> Signup and view all the answers

What is the role of sweat glands in temperature regulation?

<p>to cool the body through evaporation of sweat</p> Signup and view all the answers

How do dermal blood vessels contribute to body temperature regulation?

<p>by regulating blood flow to and from the periphery of the body, allowing for heat conservation or release</p> Signup and view all the answers

What is the significance of the autonomic motor neurons in controlling skin functions?

<p>they regulate sweat glands, sebaceous glands, and dermal blood vessels to maintain homeostasis</p> Signup and view all the answers

How do transdermal patches release drugs into the bloodstream?

<p>through the epidermis and into the blood vessels within the dermis, allowing for slow and continuous absorption</p> Signup and view all the answers

Study Notes

Integumentary System

  • The integument is the body's largest organ, composed of all tissue types that function together to protect internal body structures.
  • It consists of two distinct layers: epidermis (stratified squamous epithelium) and dermis (both areolar and dense irregular connective tissue).

Epidermis

  • Thickness ranges from 0.075 mm to 0.6 mm
  • Composed of five layers: stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum
  • Keratinocytes are the most abundant cell type in the epidermis and are found throughout all epidermal strata
  • Keratinocytes synthesize keratin, a protein that strengthens the epidermis considerably
  • Melanocytes produce and store melanin, which accumulates around the nucleus of keratinocytes and shields nuclear DNA from ultraviolet (UV) radiation
  • Tactile cells (Merkel cells) are sensitive to touch and release chemicals that stimulate sensory nerve endings

Stratum Basale

  • Deepest epidermal layer, also known as the stratum germinativum or basal layer
  • Consists of cuboidal to low columnar cells tightly attached to an underlying basement membrane
  • Contains keratinocyte stem cells, melanocytes, and tactile cells

Stratum Spinosum

  • Several layers of polygonal keratinocytes
  • Keratinocytes attach to their neighbors by desmosomes, providing structural support between cells
  • Also contains Langerhans cells, which are immune cells that help fight infection in the epidermis

Stratum Granulosum

  • Consists of three to five layers of keratinocytes superficial to the stratum spinosum
  • Keratinocytes begin to synthesize significant amounts of keratin, resulting in the disintegration of their nucleus and organelles
  • Contains granules that help aggregate keratin filaments in the stratum corneum

Stratum Lucidum

  • Thin, translucent region of about two to three keratinocyte layers
  • Found only in thick skin within the palms of the hands and the soles of the feet
  • Keratinocytes are flattened, pale cells filled with eleidin, an intermediate product in keratin formation

Stratum Corneum

  • Most superficial layer of the epidermis
  • Consists of about 20 to 30 layers of dead, scaly, interlocking keratinized cells
  • Dead keratinocytes are anucleate and tightly packed together
  • Keratinized cells contain large amounts of keratin enclosed in a thickened plasma membrane

Variations in the Epidermis

  • Thickness varies between different body regions within one individual
  • Classified as either thick or thin based on the number of layers and thickness of the stratified squamous epithelium
  • Thick skin lacks hair follicles and sebaceous glands, whereas thin skin contains hair follicles, sebaceous glands, and sweat glands

Skin Color

  • Results from a combination of hemoglobin, melanin, and carotene
  • Melanin is produced and stored in melanocytes and transferred to keratinocytes
  • Carotene is a yellow-orange pigment acquired from yellow-orange vegetables
  • Vitamin A is converted from carotene in the liver and plays an important role in vision and reducing free radicals### Malignant Melanomas and Skin Markings
  • Malignant melanomas develop due to excessive UV light exposure, and nevi should be monitored for changes that may suggest malignancy.
  • Freckles are yellowish or brown spots that represent localized areas of increased melanocyte activity, not an increase in melanocyte numbers.
  • Hemangiomas are anomalies that result in skin discoloration due to blood vessels that proliferate to form a benign tumor.
    • Capillary hemangiomas, also known as strawberry-colored birthmarks, appear as bright red to deep purple nodules.
    • Cavernous hemangiomas, also known as port-wine stains, involve larger dermal blood vessels and may last a lifetime.
  • Friction ridges are markings on the skin that follow the contours of the skin, found on palms, fingers, soles, and toes.
    • They help increase friction on contact, allowing hands to firmly grasp items and feet to prevent slipping when walking barefoot.
    • Friction ridges are a unique identifier, with no two individuals sharing the same set of fingerprints.

Dermis

  • The dermis is the layer of the integument deep to the epidermis, ranging in thickness from 0.5 mm to 3.0 mm.
  • It is composed of connective tissue proper, primarily containing collagen fibers, as well as elastic and reticular fibers.
  • The dermis contains:
    • Dendritic cells, which serve an immune function.
    • Blood vessels.
    • Sweat glands.
    • Sebaceous glands.
    • Hair follicles.
    • Nail roots.
    • Sensory nerve endings.
    • Smooth muscle tissue associated with hair follicles.
  • The dermis has two major regions:
    • Papillary layer: a superficial layer of areolar connective tissue with dermal papillae that interdigitate with epidermal ridges.
    • Reticular layer: a deeper layer of dense irregular connective tissue with collagen fibers extending in all directions.

Cleavage Lines and Stretch Marks

  • Lines of cleavage are areas where collagen fibers are aligned in parallel bundles due to applied stress during routine movement.
  • These lines are medically important because incisions made parallel to cleavage lines usually remain closed, whereas those made perpendicular to cleavage lines may result in slow healing and increased scarring.
  • Stretch marks, or striae, occur when the skin is stretched beyond its capacity, causing collagen fibers to tear.

Subcutaneous Layer

  • The subcutaneous layer, also known as the hypodermis or superficial fascia, is the layer deep to the integument.
  • It consists of both areolar connective tissue and adipose connective tissue.
  • The subcutaneous layer pads and protects the body, acts as an energy reservoir, and provides thermal insulation.
  • It is also where drugs are often injected using hypodermic needles, as its extensive vascular network promotes rapid absorption.

Functions of the Integument

  • Protection from the external environment.

  • Prevention of water loss and gain.

  • Vitamin D synthesis: keratinocytes in the epidermis convert a steroid molecule to vitamin D3, which is then released into the blood.

  • Secretion: sweat glands excrete sweat, which helps regulate body temperature, and sebaceous glands excrete sebum, which lubricates the epidermis and hair.

  • Absorption: the skin can absorb certain chemicals and drugs, making it selectively permeable.

  • Temperature regulation: the dermis helps regulate body temperature through its vast capillary networks and sweat glands.### Thermoregulation and Skin Color

  • Vasodilation of dermal blood vessels increases blood flow to the skin surface, resulting in a more reddish/pinkish hue.

  • This process helps to release excess heat from the body.

  • Conversely, vasoconstriction leads to reduced blood flow, making the skin appear paler.

  • Flushing of the face occurs when exercising or moving from a cold to a warm environment due to increased blood flow.

Immune Function

  • Epidermal dendritic cells in the stratum spinosum play a crucial role in initiating an immune response against pathogens that penetrate the skin.
  • These cells, along with dermal dendritic cells, also attack epidermal cancer cells.

Sensory Reception

  • The skin contains a vast number of sensory nerve endings that detect and interpret various stimuli, including touch and pressure.
  • Seven major types of sensory receptors are present in the skin to distinguish and respond to different stimuli.

Integument Functions

  • The skin's composition, including the epidermis and dermis, enables it to perform several functions, such as:
    • Protecting the body from the external environment
    • Preventing water loss and gain
    • Synthesizing vitamin D
    • Secreting and absorbing substances
    • Regulating temperature
    • Facilitating immune function
    • Enabling sensory reception

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Learn about the composition and functions of the integument, the body's largest organ, including its epithelium, connective tissue, and smooth muscle associated with hair follicles.

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