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Questions and Answers
What percentage of the body weight does the integument account for?
What percentage of the body weight does the integument account for?
7% to 8%
What is the range of thickness of the integument?
What is the range of thickness of the integument?
1.5 mm to 4 mm or more
What is the outermost layer of the integument called?
What is the outermost layer of the integument called?
Epidermis
What type of connective tissue is found deep to the epithelium?
What type of connective tissue is found deep to the epithelium?
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What is the function of the arrector pili muscle?
What is the function of the arrector pili muscle?
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What is the layer of tissue deep to the integument called?
What is the layer of tissue deep to the integument called?
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What type of tissue detects and monitors sensory stimuli in the integument?
What type of tissue detects and monitors sensory stimuli in the integument?
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What is the area of the skin in square meters?
What is the area of the skin in square meters?
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What is the term for the epithelium of the integument?
What is the term for the epithelium of the integument?
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What is the range of thickness of the entire integument?
What is the range of thickness of the entire integument?
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What is the name of the layer of the epidermis that contains dead cells?
What is the name of the layer of the epidermis that contains dead cells?
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What type of cells are most abundant in the epidermis?
What type of cells are most abundant in the epidermis?
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What is the function of melanin in the epidermis?
What is the function of melanin in the epidermis?
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What is the name of the cells sensitive to touch in the stratum basale?
What is the name of the cells sensitive to touch in the stratum basale?
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What is the term for the single layer of cuboidal to low columnar cells in the deepest epidermal layer?
What is the term for the single layer of cuboidal to low columnar cells in the deepest epidermal layer?
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What is the name of the organelles that transfer melanin pigment to keratinocytes?
What is the name of the organelles that transfer melanin pigment to keratinocytes?
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What type of protein do keratinocytes synthesize?
What type of protein do keratinocytes synthesize?
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What is the term for the process of melanocytes producing melanin to block UV light?
What is the term for the process of melanocytes producing melanin to block UV light?
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What type of cell does a new cell in the stratum spinosum differentiate into?
What type of cell does a new cell in the stratum spinosum differentiate into?
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What is the function of desmosomes in the stratum spinosum?
What is the function of desmosomes in the stratum spinosum?
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Why do keratinocytes in the stratum spinosum resemble miniature porcupines?
Why do keratinocytes in the stratum spinosum resemble miniature porcupines?
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What is the role of epidermal dendritic (Langerhans) cells in the epidermis?
What is the role of epidermal dendritic (Langerhans) cells in the epidermis?
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What process begins in the stratum granulosum?
What process begins in the stratum granulosum?
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What is the function of the stratum lucidum?
What is the function of the stratum lucidum?
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What is the composition of the stratum corneum?
What is the composition of the stratum corneum?
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What is the result of keratinization in the stratum corneum?
What is the result of keratinization in the stratum corneum?
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How long does the migration of a keratinocyte to the stratum corneum take?
How long does the migration of a keratinocyte to the stratum corneum take?
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What is the result of the death of keratinocytes in the stratum corneum?
What is the result of the death of keratinocytes in the stratum corneum?
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What is the function of hemoglobin in red blood cells, and how does it affect the color of blood vessels?
What is the function of hemoglobin in red blood cells, and how does it affect the color of blood vessels?
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What are the two types of melanin, and what colors do they produce in the skin?
What are the two types of melanin, and what colors do they produce in the skin?
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How does melanocyte activity affect the color of the entire epidermis?
How does melanocyte activity affect the color of the entire epidermis?
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What is carotene, and where is it typically found in the skin?
What is carotene, and where is it typically found in the skin?
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What is the difference in melanocyte activity between darker-skinned and lighter-skinned individuals?
What is the difference in melanocyte activity between darker-skinned and lighter-skinned individuals?
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How does exposure to UV light affect skin color, and what is the role of melanocytes in this process?
How does exposure to UV light affect skin color, and what is the role of melanocytes in this process?
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What are the three forms of ultraviolet radiation, and how do they affect the skin?
What are the three forms of ultraviolet radiation, and how do they affect the skin?
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What is the role of vitamin A in the body, and how is it related to carotene?
What is the role of vitamin A in the body, and how is it related to carotene?
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How do UVA and UVB rays differ in their effects on the skin, and what is the myth about UVA rays?
How do UVA and UVB rays differ in their effects on the skin, and what is the myth about UVA rays?
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What is the relationship between melanin and skin color, and how is it influenced by heredity and environmental factors?
What is the relationship between melanin and skin color, and how is it influenced by heredity and environmental factors?
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What is the purpose of applying sunscreen liberally over all exposed body surfaces, and reapplying after being in the water or perspiring?
What is the purpose of applying sunscreen liberally over all exposed body surfaces, and reapplying after being in the water or perspiring?
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How do sunless tanners produce a tanned, bronzed skin without UV light exposure?
How do sunless tanners produce a tanned, bronzed skin without UV light exposure?
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What is the result of the nonfunctional enzyme needed to produce melanin in individuals with albinism?
What is the result of the nonfunctional enzyme needed to produce melanin in individuals with albinism?
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What is the significance of monitoring nevi for changes?
What is the significance of monitoring nevi for changes?
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What is the difference between capillary hemangiomas and cavernous hemangiomas?
What is the difference between capillary hemangiomas and cavernous hemangiomas?
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What is the purpose of friction ridges on the palms, fingers, soles, and toes?
What is the purpose of friction ridges on the palms, fingers, soles, and toes?
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What is the term for the study of friction ridge patterns?
What is the term for the study of friction ridge patterns?
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Why is it important to apply sunscreen when using sunless tanners?
Why is it important to apply sunscreen when using sunless tanners?
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What determines the degree of pigmentation in freckles?
What determines the degree of pigmentation in freckles?
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What is the significance of the SPF number on sunscreens?
What is the significance of the SPF number on sunscreens?
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What purpose does the stratum corneum serve in the integument, and how long do the dead, keratinized cells remain in this layer?
What purpose does the stratum corneum serve in the integument, and how long do the dead, keratinized cells remain in this layer?
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What is the main difference between thick skin and thin skin, and where is each type typically found?
What is the main difference between thick skin and thin skin, and where is each type typically found?
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What are some exocrine gland secretions that help prevent the growth of microorganisms on the epidermis?
What are some exocrine gland secretions that help prevent the growth of microorganisms on the epidermis?
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Why do you think thick skin lacks hair follicles and sebaceous glands?
Why do you think thick skin lacks hair follicles and sebaceous glands?
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What determines the normal skin color, and what are the contributors to this color?
What determines the normal skin color, and what are the contributors to this color?
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How can you identify the epidermal strata using light microscopy, and what features should you look for?
How can you identify the epidermal strata using light microscopy, and what features should you look for?
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What are the thickness ranges of the epidermis in thick skin and thin skin?
What are the thickness ranges of the epidermis in thick skin and thin skin?
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What are the structures found in thin skin, and how do they differ from those found in thick skin?
What are the structures found in thin skin, and how do they differ from those found in thick skin?
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What is the lifespan of individual keratinocytes in the integument, and how long do they remain in the stratum corneum?
What is the lifespan of individual keratinocytes in the integument, and how long do they remain in the stratum corneum?
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What is the significance of the stratum lucidum in thick skin, and how does it differ from thin skin?
What is the significance of the stratum lucidum in thick skin, and how does it differ from thin skin?
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What is the significance of the interlocking projections in the model of the epidermis and dermis?
What is the significance of the interlocking projections in the model of the epidermis and dermis?
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What is the clinical significance of lines of cleavage in the skin?
What is the clinical significance of lines of cleavage in the skin?
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How do collagen and elastic fibers contribute to the physical characteristics of the skin?
How do collagen and elastic fibers contribute to the physical characteristics of the skin?
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What is the significance of friction ridge patterns in dermatoglyphics, and how do they form?
What is the significance of friction ridge patterns in dermatoglyphics, and how do they form?
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What causes stretch marks, and how do they affect the skin?
What causes stretch marks, and how do they affect the skin?
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What layers of the epidermis would be penetrated by a thorn, starting from the surface of the skin?
What layers of the epidermis would be penetrated by a thorn, starting from the surface of the skin?
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How do tattoos become permanent, and why is it difficult to remove them?
How do tattoos become permanent, and why is it difficult to remove them?
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Compare and contrast the papillary and reticular layers of the dermis.
Compare and contrast the papillary and reticular layers of the dermis.
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Briefly describe the process of keratinization. Where does it occur, and why is it important?
Briefly describe the process of keratinization. Where does it occur, and why is it important?
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How does hemoglobin contribute to skin color?
How does hemoglobin contribute to skin color?
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What is the function of the subcutaneous layer, and what type of tissue does it consist of?
What is the function of the subcutaneous layer, and what type of tissue does it consist of?
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How does the skin produce vitamin D?
How does the skin produce vitamin D?
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What are the two major regions of the dermis, and what are their characteristics?
What are the two major regions of the dermis, and what are their characteristics?
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What is the role of dermal papillae in the skin?
What is the role of dermal papillae in the skin?
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What is the function of dermal papillae, and how do they interact with epidermal ridges?
What is the function of dermal papillae, and how do they interact with epidermal ridges?
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How do surgical procedures take into account lines of cleavage in the skin?
How do surgical procedures take into account lines of cleavage in the skin?
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What type of connective tissue is found in the papillary layer, and what type is found in the reticular layer?
What type of connective tissue is found in the papillary layer, and what type is found in the reticular layer?
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What is the significance of cleavage lines in the dermis?
What is the significance of cleavage lines in the dermis?
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What is the role of dendritic cells in the dermis, and how do they compare to epidermal dendritic cells?
What is the role of dendritic cells in the dermis, and how do they compare to epidermal dendritic cells?
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What structures are found within the dermis, and what is their significance?
What structures are found within the dermis, and what is their significance?
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What is the primary function of the seven major types of sensory receptors housed within the skin?
What is the primary function of the seven major types of sensory receptors housed within the skin?
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How does exposure to ultraviolet light affect the dermis?
How does exposure to ultraviolet light affect the dermis?
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What is the significance of the dermis in relation to the skin's functions?
What is the significance of the dermis in relation to the skin's functions?
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What are some ways the skin can dissipate excess heat?
What are some ways the skin can dissipate excess heat?
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How does the anatomy of the integument support its various functions?
How does the anatomy of the integument support its various functions?
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What is the importance of the skin's immune function?
What is the importance of the skin's immune function?
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What is the significance of the connective tissue fibers in the reticular layer of the dermis and subcutaneous layer?
What is the significance of the connective tissue fibers in the reticular layer of the dermis and subcutaneous layer?
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Why are drugs often injected into the subcutaneous layer?
Why are drugs often injected into the subcutaneous layer?
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How do sex hormones influence the distribution of subcutaneous fat?
How do sex hormones influence the distribution of subcutaneous fat?
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What is the primary function of the papillary layer of the dermis?
What is the primary function of the papillary layer of the dermis?
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What are the two main functions of the integument in terms of temperature regulation?
What are the two main functions of the integument in terms of temperature regulation?
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How does the integumentary system interact with the immune system?
How does the integumentary system interact with the immune system?
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What is the role of the integument in maintaining blood volume?
What is the role of the integument in maintaining blood volume?
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How does the integumentary system aid in the synthesis of vitamin D?
How does the integumentary system aid in the synthesis of vitamin D?
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What is the significance of hairs in the nasal cavity?
What is the significance of hairs in the nasal cavity?
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What is the role of the integument in the excretion of nitrogenous waste products?
What is the role of the integument in the excretion of nitrogenous waste products?
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What is the main function of the skin in terms of protection from the external environment?
What is the main function of the skin in terms of protection from the external environment?
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How does the skin prevent water loss and water gain?
How does the skin prevent water loss and water gain?
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What is the role of keratinocytes in vitamin D synthesis?
What is the role of keratinocytes in vitamin D synthesis?
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Why did children during the Industrial Revolution develop rickets?
Why did children during the Industrial Revolution develop rickets?
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What is the skin's role in electrolyte homeostasis?
What is the skin's role in electrolyte homeostasis?
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What is the significance of melanin in the epidermis?
What is the significance of melanin in the epidermis?
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How does the skin's secretory function contribute to thermoregulation?
How does the skin's secretory function contribute to thermoregulation?
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What is the role of corticosteroids in the skin?
What is the role of corticosteroids in the skin?
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How does the skin's water-resistant properties affect its role in preventing water gain?
How does the skin's water-resistant properties affect its role in preventing water gain?
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What is the relationship between vitamin D synthesis and UV light exposure in the skin?
What is the relationship between vitamin D synthesis and UV light exposure in the skin?
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What is the function of sebaceous glands in the skin?
What is the function of sebaceous glands in the skin?
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How do transdermal patches work to administer drugs?
How do transdermal patches work to administer drugs?
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What is the effect of vasoconstriction on dermal blood vessels?
What is the effect of vasoconstriction on dermal blood vessels?
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What is the function of epidermal dendritic cells in the immune response?
What is the function of epidermal dendritic cells in the immune response?
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What is the effect of vasodilation on dermal blood vessels?
What is the effect of vasodilation on dermal blood vessels?
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Why is the skin selectively permeable?
Why is the skin selectively permeable?
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What is the role of sweat glands in temperature regulation?
What is the role of sweat glands in temperature regulation?
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How do dermal blood vessels contribute to body temperature regulation?
How do dermal blood vessels contribute to body temperature regulation?
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What is the significance of the autonomic motor neurons in controlling skin functions?
What is the significance of the autonomic motor neurons in controlling skin functions?
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How do transdermal patches release drugs into the bloodstream?
How do transdermal patches release drugs into the bloodstream?
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Study Notes
Integumentary System
- The integument is the body's largest organ, composed of all tissue types that function together to protect internal body structures.
- It consists of two distinct layers: epidermis (stratified squamous epithelium) and dermis (both areolar and dense irregular connective tissue).
Epidermis
- Thickness ranges from 0.075 mm to 0.6 mm
- Composed of five layers: stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum
- Keratinocytes are the most abundant cell type in the epidermis and are found throughout all epidermal strata
- Keratinocytes synthesize keratin, a protein that strengthens the epidermis considerably
- Melanocytes produce and store melanin, which accumulates around the nucleus of keratinocytes and shields nuclear DNA from ultraviolet (UV) radiation
- Tactile cells (Merkel cells) are sensitive to touch and release chemicals that stimulate sensory nerve endings
Stratum Basale
- Deepest epidermal layer, also known as the stratum germinativum or basal layer
- Consists of cuboidal to low columnar cells tightly attached to an underlying basement membrane
- Contains keratinocyte stem cells, melanocytes, and tactile cells
Stratum Spinosum
- Several layers of polygonal keratinocytes
- Keratinocytes attach to their neighbors by desmosomes, providing structural support between cells
- Also contains Langerhans cells, which are immune cells that help fight infection in the epidermis
Stratum Granulosum
- Consists of three to five layers of keratinocytes superficial to the stratum spinosum
- Keratinocytes begin to synthesize significant amounts of keratin, resulting in the disintegration of their nucleus and organelles
- Contains granules that help aggregate keratin filaments in the stratum corneum
Stratum Lucidum
- Thin, translucent region of about two to three keratinocyte layers
- Found only in thick skin within the palms of the hands and the soles of the feet
- Keratinocytes are flattened, pale cells filled with eleidin, an intermediate product in keratin formation
Stratum Corneum
- Most superficial layer of the epidermis
- Consists of about 20 to 30 layers of dead, scaly, interlocking keratinized cells
- Dead keratinocytes are anucleate and tightly packed together
- Keratinized cells contain large amounts of keratin enclosed in a thickened plasma membrane
Variations in the Epidermis
- Thickness varies between different body regions within one individual
- Classified as either thick or thin based on the number of layers and thickness of the stratified squamous epithelium
- Thick skin lacks hair follicles and sebaceous glands, whereas thin skin contains hair follicles, sebaceous glands, and sweat glands
Skin Color
- Results from a combination of hemoglobin, melanin, and carotene
- Melanin is produced and stored in melanocytes and transferred to keratinocytes
- Carotene is a yellow-orange pigment acquired from yellow-orange vegetables
- Vitamin A is converted from carotene in the liver and plays an important role in vision and reducing free radicals### Malignant Melanomas and Skin Markings
- Malignant melanomas develop due to excessive UV light exposure, and nevi should be monitored for changes that may suggest malignancy.
- Freckles are yellowish or brown spots that represent localized areas of increased melanocyte activity, not an increase in melanocyte numbers.
- Hemangiomas are anomalies that result in skin discoloration due to blood vessels that proliferate to form a benign tumor.
- Capillary hemangiomas, also known as strawberry-colored birthmarks, appear as bright red to deep purple nodules.
- Cavernous hemangiomas, also known as port-wine stains, involve larger dermal blood vessels and may last a lifetime.
- Friction ridges are markings on the skin that follow the contours of the skin, found on palms, fingers, soles, and toes.
- They help increase friction on contact, allowing hands to firmly grasp items and feet to prevent slipping when walking barefoot.
- Friction ridges are a unique identifier, with no two individuals sharing the same set of fingerprints.
Dermis
- The dermis is the layer of the integument deep to the epidermis, ranging in thickness from 0.5 mm to 3.0 mm.
- It is composed of connective tissue proper, primarily containing collagen fibers, as well as elastic and reticular fibers.
- The dermis contains:
- Dendritic cells, which serve an immune function.
- Blood vessels.
- Sweat glands.
- Sebaceous glands.
- Hair follicles.
- Nail roots.
- Sensory nerve endings.
- Smooth muscle tissue associated with hair follicles.
- The dermis has two major regions:
- Papillary layer: a superficial layer of areolar connective tissue with dermal papillae that interdigitate with epidermal ridges.
- Reticular layer: a deeper layer of dense irregular connective tissue with collagen fibers extending in all directions.
Cleavage Lines and Stretch Marks
- Lines of cleavage are areas where collagen fibers are aligned in parallel bundles due to applied stress during routine movement.
- These lines are medically important because incisions made parallel to cleavage lines usually remain closed, whereas those made perpendicular to cleavage lines may result in slow healing and increased scarring.
- Stretch marks, or striae, occur when the skin is stretched beyond its capacity, causing collagen fibers to tear.
Subcutaneous Layer
- The subcutaneous layer, also known as the hypodermis or superficial fascia, is the layer deep to the integument.
- It consists of both areolar connective tissue and adipose connective tissue.
- The subcutaneous layer pads and protects the body, acts as an energy reservoir, and provides thermal insulation.
- It is also where drugs are often injected using hypodermic needles, as its extensive vascular network promotes rapid absorption.
Functions of the Integument
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Protection from the external environment.
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Prevention of water loss and gain.
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Vitamin D synthesis: keratinocytes in the epidermis convert a steroid molecule to vitamin D3, which is then released into the blood.
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Secretion: sweat glands excrete sweat, which helps regulate body temperature, and sebaceous glands excrete sebum, which lubricates the epidermis and hair.
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Absorption: the skin can absorb certain chemicals and drugs, making it selectively permeable.
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Temperature regulation: the dermis helps regulate body temperature through its vast capillary networks and sweat glands.### Thermoregulation and Skin Color
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Vasodilation of dermal blood vessels increases blood flow to the skin surface, resulting in a more reddish/pinkish hue.
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This process helps to release excess heat from the body.
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Conversely, vasoconstriction leads to reduced blood flow, making the skin appear paler.
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Flushing of the face occurs when exercising or moving from a cold to a warm environment due to increased blood flow.
Immune Function
- Epidermal dendritic cells in the stratum spinosum play a crucial role in initiating an immune response against pathogens that penetrate the skin.
- These cells, along with dermal dendritic cells, also attack epidermal cancer cells.
Sensory Reception
- The skin contains a vast number of sensory nerve endings that detect and interpret various stimuli, including touch and pressure.
- Seven major types of sensory receptors are present in the skin to distinguish and respond to different stimuli.
Integument Functions
- The skin's composition, including the epidermis and dermis, enables it to perform several functions, such as:
- Protecting the body from the external environment
- Preventing water loss and gain
- Synthesizing vitamin D
- Secreting and absorbing substances
- Regulating temperature
- Facilitating immune function
- Enabling sensory reception
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Description
Learn about the composition and functions of the integument, the body's largest organ, including its epithelium, connective tissue, and smooth muscle associated with hair follicles.