Podcast
Questions and Answers
What is one key characteristic of innate immunity?
What is one key characteristic of innate immunity?
- It provides specific defense against infections.
- It is a newer evolutionary development than adaptive immunity.
- It is always present in healthy individuals. (correct)
- It requires prior exposure to pathogens.
How does adaptive immunity differ from innate immunity?
How does adaptive immunity differ from innate immunity?
- It provides immediate defense against infections.
- It requires the expansion and differentiation of lymphocytes. (correct)
- It utilizes the same mechanisms as innate immunity.
- It is phylogenetically older.
Which of the following cells is involved in innate immunity?
Which of the following cells is involved in innate immunity?
- B lymphocytes
- T lymphocytes
- Natural killer cells (correct)
- Plasma cells
What is the role of phagocytes in innate immunity?
What is the role of phagocytes in innate immunity?
Which statement accurately describes adaptive immunity?
Which statement accurately describes adaptive immunity?
What is the primary role of antibodies in humoral immunity?
What is the primary role of antibodies in humoral immunity?
How do T lymphocytes recognize infected cells in cell-mediated immunity?
How do T lymphocytes recognize infected cells in cell-mediated immunity?
Which type of immunity is described as being mediated by T lymphocytes?
Which type of immunity is described as being mediated by T lymphocytes?
What distinguishes T cells from B cells in their recognition of antigens?
What distinguishes T cells from B cells in their recognition of antigens?
What type of immunity is conferred by the transfer of antibodies from one individual to another?
What type of immunity is conferred by the transfer of antibodies from one individual to another?
What is one function of phagocytes in immune response?
What is one function of phagocytes in immune response?
Which feature of the immune system ensures distinct antigens elicit specific responses?
Which feature of the immune system ensures distinct antigens elicit specific responses?
What is a significant limitation of antibodies regarding intracellular microbes?
What is a significant limitation of antibodies regarding intracellular microbes?
What is a clone in the context of lymphocytes?
What is a clone in the context of lymphocytes?
How are antigen-specific clones of lymphocytes activated?
How are antigen-specific clones of lymphocytes activated?
What role do generative lymphoid organs play in the immune response?
What role do generative lymphoid organs play in the immune response?
What is the outcome of clonal selection in the adaptive immune response?
What is the outcome of clonal selection in the adaptive immune response?
Which type of lymphocyte is specifically mentioned in the context of antibody secretion?
Which type of lymphocyte is specifically mentioned in the context of antibody secretion?
What is primarily selected by antigen during clonal selection?
What is primarily selected by antigen during clonal selection?
What happens to the mature lymphocyte clones after they enter lymphoid tissues?
What happens to the mature lymphocyte clones after they enter lymphoid tissues?
What best describes the specificity and diversity of lymphocytes?
What best describes the specificity and diversity of lymphocytes?
What characteristic of adaptive immunity allows for a broad response to various antigens?
What characteristic of adaptive immunity allows for a broad response to various antigens?
What happens to naive lymphocytes when they encounter an antigen for the first time?
What happens to naive lymphocytes when they encounter an antigen for the first time?
Which benefit does immunologic memory provide to the immune system?
Which benefit does immunologic memory provide to the immune system?
What is the primary immune response characterized by?
What is the primary immune response characterized by?
How many naive lymphocytes are estimated to be specific for any one antigen?
How many naive lymphocytes are estimated to be specific for any one antigen?
What is the role of selection mechanisms in adaptive immunity?
What is the role of selection mechanisms in adaptive immunity?
What defines a secondary immune response?
What defines a secondary immune response?
Which statement regarding naive lymphocytes is incorrect?
Which statement regarding naive lymphocytes is incorrect?
What receptor do naive T lymphocytes express that allows them to migrate to specific regions in lymph nodes and spleen?
What receptor do naive T lymphocytes express that allows them to migrate to specific regions in lymph nodes and spleen?
How do plasma cells contribute to the immune response?
How do plasma cells contribute to the immune response?
What facilitates the interaction between B cells and activated helper T cells during an immune response?
What facilitates the interaction between B cells and activated helper T cells during an immune response?
What type of venules do naive T lymphocytes enter lymph nodes through?
What type of venules do naive T lymphocytes enter lymph nodes through?
What is the primary role of chemokine receptors on T lymphocytes during their activation?
What is the primary role of chemokine receptors on T lymphocytes during their activation?
What occurs when lymphocytes are activated by antigens?
What occurs when lymphocytes are activated by antigens?
What is the function of the specialized postcapillary venules in lymph nodes?
What is the function of the specialized postcapillary venules in lymph nodes?
Where do plasma cells in mucosal organs secrete antibodies?
Where do plasma cells in mucosal organs secrete antibodies?
What is the primary role of dendritic cells in lymph nodes?
What is the primary role of dendritic cells in lymph nodes?
Where are B lymphocytes primarily located within the lymph nodes?
Where are B lymphocytes primarily located within the lymph nodes?
What distinguishes T lymphocytes from B lymphocytes in the tissue sections described?
What distinguishes T lymphocytes from B lymphocytes in the tissue sections described?
What is the significance of germinal centers within lymph node follicles?
What is the significance of germinal centers within lymph node follicles?
Why do mucosal and cutaneous immune systems not react to commensal microbes?
Why do mucosal and cutaneous immune systems not react to commensal microbes?
How do naive B and T lymphocytes enter the lymph nodes?
How do naive B and T lymphocytes enter the lymph nodes?
Which of the following statements about lymphocyte segregation is true?
Which of the following statements about lymphocyte segregation is true?
What type of lymphocytes mainly populate mucosal tissues?
What type of lymphocytes mainly populate mucosal tissues?
Flashcards
Innate Immunity
Innate Immunity
The defense system that is always present in healthy individuals and provides an immediate response against infections.
Adaptive Immunity
Adaptive Immunity
The defense system that develops slowly after exposure to specific infections and provides more specialized protection.
Phagocytes
Phagocytes
Specialized white blood cells that engulf and destroy microbes.
Complement System
Complement System
Signup and view all the flashcards
Innate Lymphoid Cells
Innate Lymphoid Cells
Signup and view all the flashcards
Antibodies
Antibodies
Signup and view all the flashcards
Humoral Immunity
Humoral Immunity
Signup and view all the flashcards
Cell-Mediated Immunity
Cell-Mediated Immunity
Signup and view all the flashcards
Antigens
Antigens
Signup and view all the flashcards
Immunization
Immunization
Signup and view all the flashcards
Immune System Versatility
Immune System Versatility
Signup and view all the flashcards
Naive Lymphocyte
Naive Lymphocyte
Signup and view all the flashcards
Immunologic Memory
Immunologic Memory
Signup and view all the flashcards
Primary Immune Response
Primary Immune Response
Signup and view all the flashcards
Secondary Immune Response
Secondary Immune Response
Signup and view all the flashcards
Memory Lymphocyte
Memory Lymphocyte
Signup and view all the flashcards
Enhanced Immune Response
Enhanced Immune Response
Signup and view all the flashcards
Lymphocyte Selection
Lymphocyte Selection
Signup and view all the flashcards
Lymphocyte clonal selection
Lymphocyte clonal selection
Signup and view all the flashcards
Lymphocyte diversity
Lymphocyte diversity
Signup and view all the flashcards
Lymphocyte clone
Lymphocyte clone
Signup and view all the flashcards
Antigen selection
Antigen selection
Signup and view all the flashcards
Antigen-specific immune response
Antigen-specific immune response
Signup and view all the flashcards
Pre-existing lymphocyte repertoire
Pre-existing lymphocyte repertoire
Signup and view all the flashcards
Lymphocyte proliferation
Lymphocyte proliferation
Signup and view all the flashcards
Specificity and diversity in adaptive immunity
Specificity and diversity in adaptive immunity
Signup and view all the flashcards
High Endothelial Venule (HEV)
High Endothelial Venule (HEV)
Signup and view all the flashcards
Chemokines
Chemokines
Signup and view all the flashcards
Dendritic Cells
Dendritic Cells
Signup and view all the flashcards
Germinal Center
Germinal Center
Signup and view all the flashcards
Memory Cells
Memory Cells
Signup and view all the flashcards
Regulatory T Cells
Regulatory T Cells
Signup and view all the flashcards
Anatomic Segregation of T and B Cells
Anatomic Segregation of T and B Cells
Signup and view all the flashcards
Immune Tolerance
Immune Tolerance
Signup and view all the flashcards
CCR7
CCR7
Signup and view all the flashcards
Chemokine Receptors on Naive T Cells
Chemokine Receptors on Naive T Cells
Signup and view all the flashcards
Lymphoid Organ Structure and Lymphocyte Segregation
Lymphoid Organ Structure and Lymphocyte Segregation
Signup and view all the flashcards
Chemokine Receptor Changes in Activated T cells
Chemokine Receptor Changes in Activated T cells
Signup and view all the flashcards
Lymphocyte Activation and Migration for Immune Response
Lymphocyte Activation and Migration for Immune Response
Signup and view all the flashcards
Antigen Presentation in Lymph Nodes
Antigen Presentation in Lymph Nodes
Signup and view all the flashcards
Naive T Lymphocyte Recruitment into Lymph Nodes
Naive T Lymphocyte Recruitment into Lymph Nodes
Signup and view all the flashcards
Study Notes
Introduction to the Immune System
- Immunity is resistance to disease, particularly infectious diseases
- The immune system comprises cells, tissues, and molecules that mediate resistance to infections
- An immune response involves the coordinated reaction of cells and molecules to infectious microbes
- Immunology is the study of the immune system and its responses to pathogens and damaged tissues
Innate and Adaptive Immunity
- Innate immunity provides immediate protection against microbial invasion
- Adaptive immunity (also specific or acquired immunity) develops more slowly but provides more specialized protection against infections
- Innate immunity is always present in healthy individuals
- Adaptive immunity requires expansion and differentiation of lymphocytes to respond to microbes
Role of the Immune System
- Defense against infections
- Defense against tumors
- Tissue repair
- Initiating inflammatory responses to pathogens/infection
- Barrier to transplantation and gene therapy
Types of Adaptive Immunity
- Humoral immunity, mediated by antibodies produced by B lymphocytes, defends against extracellular microbes
- Cell-mediated immunity, mediated by T lymphocytes, defends against intracellular microbes
Properties of Adaptive Immune Responses
- Specificity: Distinguishes among millions of different antigens
- Diversity: Enables response to a large variety of antigens
- Memory: Leads to enhanced responses to repeated exposures to the same antigen
- Clonal expansion: Increases the number of antigen-specific lymphocytes
- Specialization: Optimizes responses for different microbes
- Contraction and homeostasis: Allows the system to respond to new antigens
- Non-reactivity to self: Prevents injury to the host during responses
Cells of the Immune System
- Lymphocytes:
- B lymphocytes: mediate humoral immunity
- T lymphocytes: mediate cell-mediated immunity
- Antigen-presenting cells (APCs):
- Dendritic cells, macrophages, and B cells capture and present antigens to lymphocytes
- Effector cells:
- T lymphocytes; macrophages; granulocytes
- These cells function in eliminating antigens (e.g., microbes)
Tissues of the Immune System
- Generative lymphoid organs: These are where T and B lymphocytes mature (i.e., bone marrow and thymus)
- Peripheral lymphoid organs: Sites where adaptive immune responses are initiated (includes lymph nodes, spleen, mucosa)
- Key functions and types of tissue in the immune response
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.