Innate vs Adaptive Immunity Quiz

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Questions and Answers

What is one key characteristic of innate immunity?

  • It provides specific defense against infections.
  • It is a newer evolutionary development than adaptive immunity.
  • It is always present in healthy individuals. (correct)
  • It requires prior exposure to pathogens.

How does adaptive immunity differ from innate immunity?

  • It provides immediate defense against infections.
  • It requires the expansion and differentiation of lymphocytes. (correct)
  • It utilizes the same mechanisms as innate immunity.
  • It is phylogenetically older.

Which of the following cells is involved in innate immunity?

  • B lymphocytes
  • T lymphocytes
  • Natural killer cells (correct)
  • Plasma cells

What is the role of phagocytes in innate immunity?

<p>They directly attack microbes that enter host tissues. (C)</p> Signup and view all the answers

Which statement accurately describes adaptive immunity?

<p>It evolves and becomes more effective after exposure to pathogens. (B)</p> Signup and view all the answers

What is the primary role of antibodies in humoral immunity?

<p>To stop microbes from colonizing host cells (C)</p> Signup and view all the answers

How do T lymphocytes recognize infected cells in cell-mediated immunity?

<p>By recognizing microbial antigens on host cell surfaces (D)</p> Signup and view all the answers

Which type of immunity is described as being mediated by T lymphocytes?

<p>Cell-mediated immunity (D)</p> Signup and view all the answers

What distinguishes T cells from B cells in their recognition of antigens?

<p>T cells primarily recognize protein antigens (B)</p> Signup and view all the answers

What type of immunity is conferred by the transfer of antibodies from one individual to another?

<p>Passive immunity (D)</p> Signup and view all the answers

What is one function of phagocytes in immune response?

<p>To destroy ingested microbes (D)</p> Signup and view all the answers

Which feature of the immune system ensures distinct antigens elicit specific responses?

<p>Specificity (B)</p> Signup and view all the answers

What is a significant limitation of antibodies regarding intracellular microbes?

<p>They cannot access microbes living within host cells (C)</p> Signup and view all the answers

What is a clone in the context of lymphocytes?

<p>A population of lymphocytes with identical antigen receptors (D)</p> Signup and view all the answers

How are antigen-specific clones of lymphocytes activated?

<p>By encountering antigens that match their receptors (B)</p> Signup and view all the answers

What role do generative lymphoid organs play in the immune response?

<p>They generate diverse lymphocyte clones with various receptors (D)</p> Signup and view all the answers

What is the outcome of clonal selection in the adaptive immune response?

<p>The proliferation and differentiation of antigen-specific lymphocyte clones (D)</p> Signup and view all the answers

Which type of lymphocyte is specifically mentioned in the context of antibody secretion?

<p>B lymphocytes (D)</p> Signup and view all the answers

What is primarily selected by antigen during clonal selection?

<p>Pre-existing clones of specific lymphocytes (B)</p> Signup and view all the answers

What happens to the mature lymphocyte clones after they enter lymphoid tissues?

<p>They proliferate and respond to antigens (B)</p> Signup and view all the answers

What best describes the specificity and diversity of lymphocytes?

<p>They are pre-existing and specific for many different antigens (A)</p> Signup and view all the answers

What characteristic of adaptive immunity allows for a broad response to various antigens?

<p>Marked expansion of the lymphocyte pool (A)</p> Signup and view all the answers

What happens to naive lymphocytes when they encounter an antigen for the first time?

<p>They are stimulated to become memory lymphocytes. (A)</p> Signup and view all the answers

Which benefit does immunologic memory provide to the immune system?

<p>Faster, larger and more effective responses to subsequent exposures (A)</p> Signup and view all the answers

What is the primary immune response characterized by?

<p>The initial response of naive lymphocytes to their first encounter with an antigen (C)</p> Signup and view all the answers

How many naive lymphocytes are estimated to be specific for any one antigen?

<p>1 in 10,000 to 1 in 100,000 (D)</p> Signup and view all the answers

What is the role of selection mechanisms in adaptive immunity?

<p>To preserve the most useful lymphocytes after exposure to antigens. (B)</p> Signup and view all the answers

What defines a secondary immune response?

<p>Response from memory lymphocytes to a repeated antigen exposure (A)</p> Signup and view all the answers

Which statement regarding naive lymphocytes is incorrect?

<p>They have previously encountered an antigen. (C)</p> Signup and view all the answers

What receptor do naive T lymphocytes express that allows them to migrate to specific regions in lymph nodes and spleen?

<p>CCR7 (A)</p> Signup and view all the answers

How do plasma cells contribute to the immune response?

<p>They secrete antibodies into the blood. (B)</p> Signup and view all the answers

What facilitates the interaction between B cells and activated helper T cells during an immune response?

<p>Chemokines produced in the T cell zones (A)</p> Signup and view all the answers

What type of venules do naive T lymphocytes enter lymph nodes through?

<p>High endothelial venules (HEVs) (B)</p> Signup and view all the answers

What is the primary role of chemokine receptors on T lymphocytes during their activation?

<p>To migrate towards antigen-presenting cells (A)</p> Signup and view all the answers

What occurs when lymphocytes are activated by antigens?

<p>They change their expression of chemokine receptors. (A)</p> Signup and view all the answers

What is the function of the specialized postcapillary venules in lymph nodes?

<p>They allow lymphocyte entry into lymph nodes. (A)</p> Signup and view all the answers

Where do plasma cells in mucosal organs secrete antibodies?

<p>Into the lumens of these organs (C)</p> Signup and view all the answers

What is the primary role of dendritic cells in lymph nodes?

<p>To migrate through afferent lymphatic vessels and present antigens. (D)</p> Signup and view all the answers

Where are B lymphocytes primarily located within the lymph nodes?

<p>In the follicles within the cortex. (C)</p> Signup and view all the answers

What distinguishes T lymphocytes from B lymphocytes in the tissue sections described?

<p>B lymphocytes are stained green, while T lymphocytes are stained red. (D)</p> Signup and view all the answers

What is the significance of germinal centers within lymph node follicles?

<p>They are involved in the production of antibodies. (B)</p> Signup and view all the answers

Why do mucosal and cutaneous immune systems not react to commensal microbes?

<p>Regulatory T cells suppress their activity. (B)</p> Signup and view all the answers

How do naive B and T lymphocytes enter the lymph nodes?

<p>Through high endothelial venules (HEVs). (C)</p> Signup and view all the answers

Which of the following statements about lymphocyte segregation is true?

<p>The anatomic segregation occurs in both lymph nodes and the spleen. (D)</p> Signup and view all the answers

What type of lymphocytes mainly populate mucosal tissues?

<p>Memory T cells. (D)</p> Signup and view all the answers

Flashcards

Innate Immunity

The defense system that is always present in healthy individuals and provides an immediate response against infections.

Adaptive Immunity

The defense system that develops slowly after exposure to specific infections and provides more specialized protection.

Phagocytes

Specialized white blood cells that engulf and destroy microbes.

Complement System

A group of proteins that work together to destroy microbes by complementing the immune system.

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Innate Lymphoid Cells

Lymphocytes that are part of the innate immune system and help fight infection.

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Antibodies

Secreted proteins produced by B lymphocytes that bind to and neutralize microbes, preventing them from entering cells and causing infection.

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Humoral Immunity

A type of immune response that involves the production of antibodies by B lymphocytes to eliminate extracellular microbes.

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Cell-Mediated Immunity

A type of immune response that involves T lymphocytes directly attacking infected cells or activating phagocytes to destroy ingested microbes.

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Antigens

Specific molecules that are recognized by the immune system as foreign and trigger an immune response.

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Immunization

The process by which the immune system is stimulated to create a specific immune response.

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Immune System Versatility

The ability of the immune system to respond to a wide range of antigens.

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Naive Lymphocyte

A type of lymphocyte that has not been activated by an antigen.

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Immunologic Memory

The ability of the immune system to remember prior exposures to specific antigens.

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Primary Immune Response

The first exposure to an antigen and the immune response it triggers.

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Secondary Immune Response

The immune response triggered by a subsequent exposure to the same antigen.

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Memory Lymphocyte

A long-lived cell that 'remembers' a previous exposure to an antigen.

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Enhanced Immune Response

The increased effectiveness and speed of the immune response due to prior exposure to an antigen.

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Lymphocyte Selection

The process by which specific lymphocytes are selected and expanded to fight a particular antigen.

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Lymphocyte clonal selection

Lymphocytes with diverse receptors arise in generative lymphoid organs, creating clones of lymphocytes. These clones encounter antigens in lymphoid tissues and are activated (selected) by specific antigens.

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Lymphocyte diversity

Clones of mature lymphocytes specific for various antigens enter lymphoid tissues.

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Lymphocyte clone

A population of lymphocytes with identical antigen receptors and specificities, all derived from one precursor cell.

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Antigen selection

Specific clones of lymphocytes are activated by antigens, leading to proliferation and differentiation.

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Antigen-specific immune response

Antigen-specific immune responses occur, resulting in the production of antibodies and other immune responses.

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Pre-existing lymphocyte repertoire

Mature lymphocytes with receptors for many antigens develop before encountering these antigens. This ensures a wide range of potential targets.

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Lymphocyte proliferation

A large number of lymphocytes capable of destroying microbes are needed to mount an effective defense.

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Specificity and diversity in adaptive immunity

Lymphocytes have to be able to recognize and eliminate a wide variety of microbes.

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High Endothelial Venule (HEV)

Specialized blood vessels that allow lymphocytes to enter lymph nodes from the bloodstream.

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Chemokines

Chemical messengers that attract specific types of immune cells to different areas within lymph nodes, directing their movement.

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Dendritic Cells

Specialized immune cells that capture antigens from tissues and migrate to lymph nodes to present them to T cells, initiating an immune response.

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Germinal Center

A central region within a lymph node follicle where activated B cells proliferate and differentiate into antibody-producing cells.

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Memory Cells

Lymphocytes that are already primed to recognize specific antigens, providing a faster and more effective immune response upon re-exposure.

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Regulatory T Cells

Specialized lymphocytes that suppress the activity of other T cells, preventing excessive immune responses and autoimmune diseases.

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Anatomic Segregation of T and B Cells

The segregation of T and B lymphocytes into distinct areas within the lymph node, optimizing their interactions and immune responses.

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Immune Tolerance

The ability of the immune system to respond to pathogens while tolerating the presence of harmless commensal microbes.

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CCR7

A chemokine receptor expressed on naive T lymphocytes that recognizes chemokines produced in the paracortex of lymph nodes and the periarteriolar lymphoid sheaths of the spleen, guiding their migration to these areas.

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Chemokine Receptors on Naive T Cells

Molecules expressed on the surface of naive T lymphocytes that bind to chemokines displayed on HEV surfaces, promoting their entry into the lymph node.

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Lymphoid Organ Structure and Lymphocyte Segregation

The structural organization of lymphoid organs prevents the interaction of naive T and B lymphocytes until they have been activated by antigens.

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Chemokine Receptor Changes in Activated T cells

Activated T cells express different chemokine receptors that direct their migration to the follicle edges, where they interact with activated B cells for immune response coordination.

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Lymphocyte Activation and Migration for Immune Response

The process of activating T and B lymphocytes in response to antigens, leading to the migration of activated T cells to the follicle edges and interaction with B cells, ultimately culminating in antibody production.

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Antigen Presentation in Lymph Nodes

Antigen-presenting cells, such as macrophages and dendritic cells, capture antigens and present them to naive T cells in the lymph nodes, initiating the immune response.

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Naive T Lymphocyte Recruitment into Lymph Nodes

The process by which naive T lymphocytes leave the blood and enter the lymph nodes through HEVs, driven by chemokines and adhesion molecules, which facilitates their interaction with antigens and the initiation of the immune response.

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Study Notes

Introduction to the Immune System

  • Immunity is resistance to disease, particularly infectious diseases
  • The immune system comprises cells, tissues, and molecules that mediate resistance to infections
  • An immune response involves the coordinated reaction of cells and molecules to infectious microbes
  • Immunology is the study of the immune system and its responses to pathogens and damaged tissues

Innate and Adaptive Immunity

  • Innate immunity provides immediate protection against microbial invasion
  • Adaptive immunity (also specific or acquired immunity) develops more slowly but provides more specialized protection against infections
  • Innate immunity is always present in healthy individuals
  • Adaptive immunity requires expansion and differentiation of lymphocytes to respond to microbes

Role of the Immune System

  • Defense against infections
  • Defense against tumors
  • Tissue repair
  • Initiating inflammatory responses to pathogens/infection
  • Barrier to transplantation and gene therapy

Types of Adaptive Immunity

  • Humoral immunity, mediated by antibodies produced by B lymphocytes, defends against extracellular microbes
  • Cell-mediated immunity, mediated by T lymphocytes, defends against intracellular microbes

Properties of Adaptive Immune Responses

  • Specificity: Distinguishes among millions of different antigens
  • Diversity: Enables response to a large variety of antigens
  • Memory: Leads to enhanced responses to repeated exposures to the same antigen
  • Clonal expansion: Increases the number of antigen-specific lymphocytes
  • Specialization: Optimizes responses for different microbes
  • Contraction and homeostasis: Allows the system to respond to new antigens
  • Non-reactivity to self: Prevents injury to the host during responses

Cells of the Immune System

  • Lymphocytes:
    • B lymphocytes: mediate humoral immunity
    • T lymphocytes: mediate cell-mediated immunity
  • Antigen-presenting cells (APCs):
    • Dendritic cells, macrophages, and B cells capture and present antigens to lymphocytes
  • Effector cells:
    • T lymphocytes; macrophages; granulocytes
    • These cells function in eliminating antigens (e.g., microbes)

Tissues of the Immune System

  • Generative lymphoid organs: These are where T and B lymphocytes mature (i.e., bone marrow and thymus)
  • Peripheral lymphoid organs: Sites where adaptive immune responses are initiated (includes lymph nodes, spleen, mucosa)
  • Key functions and types of tissue in the immune response

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