10 Questions
Which of the following best describes one of the physical barriers of innate immunity?
Presence of intraepithelial lymphocytes
What is the main function of lysozyme in innate immunity?
Breaks down peptidoglycan in bacteria
Which protein effector found in skin and mucosal secretions is involved in the innate immune response?
Antimicrobial peptides (defensins & cathelicidins)
How do neutrophils and macrophages kill bacteria within the phagolysosome?
Via the oxidative burst involving oxygen and nitrogen radicals
What is the role of an activated macrophage in the innate immune response?
Recognition of non-self through PAMPs and other structures
What is the function of Interleukin-8 (IL-8) in the immune response?
Attraction/activation of neutrophils
Which molecule is responsible for activating NK cells and influencing lymphocyte differentiation?
Interleukin-12 (IL-12)
What is the primary function of Tumor necrosis factor-α (TNF-α) in the immune response?
Increased permeability of vascular endothelium
In the context of non-specific phagocytic cells recognizing foreign tissue, what is the role of PRR (Pattern Recognition Receptor)?
To recognize the foreignness of objects in a general way
What is the significance of non-specific phagocytic cells wandering through the body?
They randomly come in contact with foreign tissue
Test your knowledge about the details of innate immunity, including innate barriers and physical barriers. Learn about the characteristics of innate immunity and the specific components of physical barriers according to Kuby Immunology 7th ed., 2013 and Abbas: Cellular and Molecular Immunology, 2018.
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