Inhibition of Fatty Acid Mobilization Quiz
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Questions and Answers

What is the common nomenclature suffix for fatty acids?

  • -oic (correct)
  • -ene
  • -ate
  • -ide
  • What is the name of the C18 unsaturated fatty acid with three double bonds?

  • Octadecatrienoic Acid (correct)
  • Octadecadienoic Acid
  • Octadecanoic Acid
  • Octadecenoic Acid
  • Where does β-Oxidation of Fatty Acids primarily occur?

  • Endoplasmic Reticulum
  • Cytoplasm
  • Mitochondria (correct)
  • Nucleus
  • How are fatty acids generally delivered from the gut to cells?

    <p>As free fatty acids in the blood</p> Signup and view all the answers

    What is the primary storage form of fatty acids in the body?

    <p>Triacylglycerols</p> Signup and view all the answers

    When are the fatty acids stored in triacylglycerols mobilized for use by peripheral tissues?

    <p>In a fasting state</p> Signup and view all the answers

    What is the main stimulus that inhibits the mobilization of fat from adipose tissue in adipocytes?

    <p>Insulin</p> Signup and view all the answers

    Which enzyme catalyzes the activation process of fatty acids in the cytoplasm?

    <p>Fatty acyl-CoA ligase</p> Signup and view all the answers

    What is the net result of the activation process of fatty acids in the cytoplasm?

    <p>Consumption of ATP</p> Signup and view all the answers

    In which organelle does the oxidation of fatty acids take place?

    <p>Mitochondria</p> Signup and view all the answers

    How is fatty acyl-CoA transported into the mitochondria for β-oxidation?

    <p>Using an acyl-carnitine intermediate</p> Signup and view all the answers

    What enzyme catalyzes the regeneration of fatty acyl-CoA within the mitochondria?

    <p>Carnitine acyltransferase II</p> Signup and view all the answers

    Which enzyme is responsible for hydrolyzing fatty acids from carbon atoms 1 or 3 of triacylglycerols?

    <p>Hormone-sensitive lipase</p> Signup and view all the answers

    What is the initial trigger for the activation of hormone-sensitive lipase in adipocytes?

    <p>Binding of hormones to cell-surface receptors</p> Signup and view all the answers

    What is the function of monoacylglycerol lipase in the process of fatty acid release?

    <p>Releasing fatty acids from monoacylglycerols</p> Signup and view all the answers

    Which molecule is phosphorylated by PKA to activate hormone-sensitive lipase?

    <p>Hormone-sensitive lipase</p> Signup and view all the answers

    What is the net result in terms of molecules after the action of hormone-sensitive lipase and related enzymes?

    <p>Three moles of free fatty acid and one mole of glycerol</p> Signup and view all the answers

    What is the role of glucagon, epinephrine, and β-corticotropin in the activation process in adipocytes?

    <p>Activating adenylate cyclase</p> Signup and view all the answers

    What is the role of enoyl CoA isomerase in the β-oxidation of unsaturated fatty acids with a double bond at an odd-numbered carbon?

    <p>Move the cis-bond to trans-bond</p> Signup and view all the answers

    In what condition would deficiencies in carnitine lead to an inability to transport fatty acids into the mitochondria for oxidation?

    <p>Newborns and pre-term infants</p> Signup and view all the answers

    Which deficiency primarily affects the liver and leads to reduced fatty acid oxidation and ketogenesis?

    <p>Carnitine Palmitoyltransferase I (CPT I)</p> Signup and view all the answers

    What are the symptoms that can manifest due to carnitine deficiencies?

    <p>Mild occasional muscle cramping to severe weakness or even death</p> Signup and view all the answers

    What is the result of Carnitine Palmitoylransferase II (CPT II) deficiency?

    <p>Recurrent muscle pain and fatigue with myoglobinuria after exercise</p> Signup and view all the answers

    How does enoyl CoA isomerase contribute to the oxidation of unsaturated fatty acids?

    <p>Isomerize the double bond to continue oxidation process</p> Signup and view all the answers

    What is the most common form of acyl-CoA dehydrogenase deficiency?

    <p>Medium Chain Acyl CoA Dehydrogenase Deficiency</p> Signup and view all the answers

    What symptoms may be observed in patients with Medium Chain Acyl CoA Dehydrogenase Deficiency during the first years of life?

    <p>Vomiting, lethargy, and coma</p> Signup and view all the answers

    What is diagnostic of Medium Chain Acyl CoA Dehydrogenase Deficiency?

    <p>Excessive urinary excretion of medium-chain dicarboxylic acids and their glycine and carnitine esters</p> Signup and view all the answers

    Which enzyme deficiency is characteristic of Refsum's disease?

    <p>Mitochondrial α-oxidizing enzyme deficiency</p> Signup and view all the answers

    What can ameliorate the symptoms of Refsum's disease?

    <p>Restriction of dairy products and ruminant meat from the diet</p> Signup and view all the answers

    Which drugs may inhibit carnitine acyltransferases?

    <p>Sulfonylurea drugs like tolbutamide and glyburide</p> Signup and view all the answers

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