Inhibition of Fatty Acid Mobilization Quiz
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Questions and Answers

What is the common nomenclature suffix for fatty acids?

  • -oic (correct)
  • -ene
  • -ate
  • -ide

What is the name of the C18 unsaturated fatty acid with three double bonds?

  • Octadecatrienoic Acid (correct)
  • Octadecadienoic Acid
  • Octadecanoic Acid
  • Octadecenoic Acid

Where does β-Oxidation of Fatty Acids primarily occur?

  • Endoplasmic Reticulum
  • Cytoplasm
  • Mitochondria (correct)
  • Nucleus

How are fatty acids generally delivered from the gut to cells?

<p>As free fatty acids in the blood (B)</p> Signup and view all the answers

What is the primary storage form of fatty acids in the body?

<p>Triacylglycerols (A)</p> Signup and view all the answers

When are the fatty acids stored in triacylglycerols mobilized for use by peripheral tissues?

<p>In a fasting state (D)</p> Signup and view all the answers

What is the main stimulus that inhibits the mobilization of fat from adipose tissue in adipocytes?

<p>Insulin (A)</p> Signup and view all the answers

Which enzyme catalyzes the activation process of fatty acids in the cytoplasm?

<p>Fatty acyl-CoA ligase (D)</p> Signup and view all the answers

What is the net result of the activation process of fatty acids in the cytoplasm?

<p>Consumption of ATP (B)</p> Signup and view all the answers

In which organelle does the oxidation of fatty acids take place?

<p>Mitochondria (D)</p> Signup and view all the answers

How is fatty acyl-CoA transported into the mitochondria for β-oxidation?

<p>Using an acyl-carnitine intermediate (C)</p> Signup and view all the answers

What enzyme catalyzes the regeneration of fatty acyl-CoA within the mitochondria?

<p>Carnitine acyltransferase II (A)</p> Signup and view all the answers

Which enzyme is responsible for hydrolyzing fatty acids from carbon atoms 1 or 3 of triacylglycerols?

<p>Hormone-sensitive lipase (A)</p> Signup and view all the answers

What is the initial trigger for the activation of hormone-sensitive lipase in adipocytes?

<p>Binding of hormones to cell-surface receptors (D)</p> Signup and view all the answers

What is the function of monoacylglycerol lipase in the process of fatty acid release?

<p>Releasing fatty acids from monoacylglycerols (C)</p> Signup and view all the answers

Which molecule is phosphorylated by PKA to activate hormone-sensitive lipase?

<p>Hormone-sensitive lipase (A)</p> Signup and view all the answers

What is the net result in terms of molecules after the action of hormone-sensitive lipase and related enzymes?

<p>Three moles of free fatty acid and one mole of glycerol (B)</p> Signup and view all the answers

What is the role of glucagon, epinephrine, and β-corticotropin in the activation process in adipocytes?

<p>Activating adenylate cyclase (C)</p> Signup and view all the answers

What is the role of enoyl CoA isomerase in the β-oxidation of unsaturated fatty acids with a double bond at an odd-numbered carbon?

<p>Move the cis-bond to trans-bond (C)</p> Signup and view all the answers

In what condition would deficiencies in carnitine lead to an inability to transport fatty acids into the mitochondria for oxidation?

<p>Newborns and pre-term infants (A)</p> Signup and view all the answers

Which deficiency primarily affects the liver and leads to reduced fatty acid oxidation and ketogenesis?

<p>Carnitine Palmitoyltransferase I (CPT I) (A)</p> Signup and view all the answers

What are the symptoms that can manifest due to carnitine deficiencies?

<p>Mild occasional muscle cramping to severe weakness or even death (D)</p> Signup and view all the answers

What is the result of Carnitine Palmitoylransferase II (CPT II) deficiency?

<p>Recurrent muscle pain and fatigue with myoglobinuria after exercise (C)</p> Signup and view all the answers

How does enoyl CoA isomerase contribute to the oxidation of unsaturated fatty acids?

<p>Isomerize the double bond to continue oxidation process (A)</p> Signup and view all the answers

What is the most common form of acyl-CoA dehydrogenase deficiency?

<p>Medium Chain Acyl CoA Dehydrogenase Deficiency (D)</p> Signup and view all the answers

What symptoms may be observed in patients with Medium Chain Acyl CoA Dehydrogenase Deficiency during the first years of life?

<p>Vomiting, lethargy, and coma (B)</p> Signup and view all the answers

What is diagnostic of Medium Chain Acyl CoA Dehydrogenase Deficiency?

<p>Excessive urinary excretion of medium-chain dicarboxylic acids and their glycine and carnitine esters (A)</p> Signup and view all the answers

Which enzyme deficiency is characteristic of Refsum's disease?

<p>Mitochondrial α-oxidizing enzyme deficiency (C)</p> Signup and view all the answers

What can ameliorate the symptoms of Refsum's disease?

<p>Restriction of dairy products and ruminant meat from the diet (C)</p> Signup and view all the answers

Which drugs may inhibit carnitine acyltransferases?

<p>Sulfonylurea drugs like tolbutamide and glyburide (B)</p> Signup and view all the answers

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