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Questions and Answers
True or false: A cell survival curve illustrates the relationship between radiation dose and cell survival proportion.
True
True or false: Reproductive integrity refers to the cell's capacity for sustained proliferation and the ability to produce a large number of progeny.
True
True or false: Clonogenic cells retain reproductive integrity and can proliferate indefinitely.
True
True or false: The plating efficiency measures the percentage of cells forming colonies in the irradiated cells.
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True or false: The linear-quadratic model fits the experimental data for the first few decades of cell survival.
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True or false: The single-target/single-hit model can explain the shoulder portion of the survival curve at low doses.
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True or false: The multitarget model assumes a single target in the cell that must be hit before the cell is killed.
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True or false: Low α/β values indicate radioresistant or late responders.
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True or false: Selective Incorporation of Structural Analogues indicates DNA as a primary target for cell killing.
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True or false: The Bystander Effect is pronounced in cells connected via gap junctions.
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True or false: Autophagy is a protective mechanism for cells to survive and generate nutrients and energy.
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True or false: Tumor suppressor genes prevent cells with damaged DNA from progressing in the cell cycle.
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True or false: Synchronously dividing cell cultures help in studying the radiosensitivity of different cell cycle phases.
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True or false: Hydroxyurea is a drug that kills S-phase cells and blocks G1 phase.
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True or false: The G2 phase of the cell cycle is usually as sensitive to radiation as the M phase.
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True or false: Hydroxyurea is a drug that kills S cells and accumulates cells at the G1/S boundary for at least 4 hours.
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True or false: Mouse jejunum's epithelial lining is a self-renewal tissue.
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True or false: The oxygen effect ratio (OER) is higher in M and G2 phases compared to late S phase.
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True or false: The cell cycle for mammalian cells consists of three phases: G1, DNA synthesis phase (S), and G2.
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True or false: The D0 of the effective dose-survival curve is the dose required to reduce the fraction of surviving cells to 37% and has a value close to 3 Gy for cells of human origin cells.
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True or false: The dose resulting in one decade of cell killing (D10) is given by D10 = 2.3 × D0.
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True or false: Three cell doublings would increase the cell number by 2 × 2 × 2 = 8.
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True or false: If the D0 is 2.2 Gy, the number of cells remaining after a total dose of 40 Gy is 10^9 × 10^−8.
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